ID H2SRL2_TAKRU Unreviewed; 805 AA.
AC H2SRL2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
GN Name=dll1 {ECO:0000313|Ensembl:ENSTRUP00000015049.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000015049.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000015049.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000015049.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; H2SRL2; -.
DR STRING; 31033.ENSTRUP00000086191; -.
DR Ensembl; ENSTRUT00000015118.3; ENSTRUP00000015049.3; ENSTRUG00000006183.3.
DR GeneTree; ENSGT00940000159781; -.
DR Proteomes; UP000005226; Chromosome 13.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF29; NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 5.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 6.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 8.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..805
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025484868"
FT TRANSMEM 536..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 177..221
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 288..326
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 328..364
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 366..403
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 405..441
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 446..482
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 484..520
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 665..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 179..188
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 192..204
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 212..221
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 316..325
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 354..363
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 393..402
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 431..440
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 472..481
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 510..519
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 805 AA; 87753 MW; 1494F8673F0CBA68 CRC64;
MGRLPLLLVI TLSVLTCQVL CSGVFELKLQ EFLNKKGVNG NVNCCPGGAA HPHQHCECKT
FFRICLKHYQ ANVSPEPPCT YGGAVTPVLG SNSFQVPETN ADSFTNPVRF QFGFTWPGTF
SLIIEALHTD SLDDLTTENA DRLISRITTQ RHLAVGDEWS KDMQTSGRTE LRYSYRFLCD
EYYYGDGCSV FCRPRDDAFG HFTCGERGEI ICNSGWKGQY CTEPICLPSC DEEHGFCDKP
GECKCRVGFS GRYCDDCIRY PGCLHGTCQQ PWQCNCQEGW GGLFCNQDLN YCTHHKPCLN
GATCTNTGQG SYTCSCLPGF TGASCEVQVN ECSGNPCRNG GSCSDNENGY KCICPPGFYG
NNCELSANTC ADGPCFNDGR CADNPEGGYF CQCPMGYAGF NCEKKIDHCS SNPCLNGAEC
VDLVNSYLCQ CPEGFSGPDC GEISSISAFC LSFPCQNGAT CQKGANGYIC TCPPGYTGEN
CSSPVSRCQH NPCHNGATCH ERGGRYLCAC VPGYGGHNCQ FLLPDVPKGQ PDDSGFPWTA
VGAGIFLVFV ILIGCSVLVV YIRVKLQFNS SHHSDTVHSD SHETMNNLTT TNNCLRGDKE
LVSIMTTSIK NTNKKADYHS ELSGSLGGLS GISALNGSEK NGFKSRYPSV EYNLVQELQP
EELSPCKEAH DEPQLKCETL DDSDSEEEYK KRQNSDASEK KQELAGCSEA KYSSTCNDTY
QSTSDVKCQS TCDVECNSPN DSKYQCTTDT IYQSVYVMSD QKDECIIATE VSTGIQVYVF
RISLSVLVEA SKILTSALSS GVILV
//
