ID H2ST70_TAKRU Unreviewed; 900 AA.
AC H2ST70;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Prominin-1a {ECO:0000313|Ensembl:ENSTRUP00000015607.3};
GN Name=LOC100653418 {ECO:0000313|Ensembl:ENSTRUP00000015607.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000015607.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000015607.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000015607.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, microvillus membrane
CC {ECO:0000256|ARBA:ARBA00004475}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004475}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the prominin family.
CC {ECO:0000256|ARBA:ARBA00006058}.
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DR AlphaFoldDB; H2ST70; -.
DR STRING; 31033.ENSTRUP00000015607; -.
DR Ensembl; ENSTRUT00000015676.3; ENSTRUP00000015607.3; ENSTRUG00000006388.3.
DR eggNOG; KOG4331; Eukaryota.
DR GeneTree; ENSGT00530000063586; -.
DR InParanoid; H2ST70; -.
DR OMA; CGNTKER; -.
DR TreeFam; TF324631; -.
DR Proteomes; UP000005226; Chromosome 14.
DR GO; GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008795; Prominin.
DR PANTHER; PTHR22730; PROMININ PROM PROTEIN; 1.
DR PANTHER; PTHR22730:SF3; PROMININ-1; 1.
DR Pfam; PF05478; Prominin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..900
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030172327"
FT TRANSMEM 81..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 502..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 819..838
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 900 AA; 100757 MW; 5829DB28D4C5F47F CRC64;
MWTSAFVPLL LLLSVSAELR QDTEPRRLPP PGKLDFGYVP AGVYETVAHY EPGPIGILFQ
LVQGFLHIVQ PNAFPQGKFA SFFLFCLPRV FLSLIFISFS LPSLHLRPQA IYYEIGFLVC
AAVGLLFAIL LPVVGLFFCM CRCCDNCGGE MHQRQRKNAD CRRGLLGTLL FSTSLVITIG
VLCAYAANQN LSSQVKNIRR YVNSNMRDLH TFANDTPMQI DYLISQYATA KNKVIYDLNN
IGPLLGGRIH DQLDKEVHAA LDGALNMAAV KIDRAMKAMR ETKEALENSS MGLEVLQEGT
GKLGFNLSLV RTSINRTLSD PGCHDEKSDA TTAQLCRNIR QSLSQLQISA NFTRLPNVNS
QLERMKAVLK MDLSIIVQKG FSSLNDTPHM VTEQTRSVVE NVQTLMDDIG KNISSFSKIF
PVQSCLSNFT IFISHVHAKI EDHYPEIDRM DFYRWIGCIT LCCMVVLVLA FNYLGLLCGT
LGYDKHASPT TRGCISNTGG TMLIAGVGIS FIFSWVLMGL VTIIFLAGGN MEKLVCEPFH
TKEVFKVVDT PYLVHPDWKN FIPGYLYNDS DMELTAESFY STCKDNRGIY SALRLDKVFN
VSSFLNITMF TKDVVARLNS VKIDLRGIIL LEAEGKQNLL DFSEAGLLEI NYADYLEEVN
KGVTVVDLLS FARELEAQTD LMPRGGLQMA LKGHAGTLRQ IHSQQIIPME QAMVMLLSSA
LNQSMRYLER TASDLPNKVL AVIEAIEAAQ YLISHNATHL INQETAKFTA TIVGYFHQYI
EWVKTALAME VAPCKPFSNM IDTVEIVTCS FLVDSMNTFW MGLGCSTLLL LPSIILAVKL
AKFYRRMETE DVYDDMEIDN NGYHSERSQV IPDPLMTSIP TYDTMNRFPR ASAPPRHIDW
//
