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Database: UniProt
Entry: H2STE0_TAKRU
LinkDB: H2STE0_TAKRU
Original site: H2STE0_TAKRU 
ID   H2STE0_TAKRU            Unreviewed;      1575 AA.
AC   H2STE0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 37.
DE   SubName: Full=Sodium channel, voltage-gated, type IV, alpha, b {ECO:0000313|Ensembl:ENSTRUP00000015677};
GN   Name=LOC101062543 {ECO:0000313|Ensembl:ENSTRUP00000015677};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000015677, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000015677}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000015677}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000015677}.
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DR   Ensembl; ENSTRUT00000015746; ENSTRUP00000015677; ENSTRUG00000006408.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028809; Na_channel_a10su.
DR   PANTHER; PTHR10037:SF208; PTHR10037:SF208; 3.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    123    144       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    156    175       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    196    220       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    240    262       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    391    414       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    496    519       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    614    637       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    662    682       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    694    717       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    871    890       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    902    921       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    927    944       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    985   1011       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1111   1129       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1189   1207       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1219   1241       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1253   1275       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1320   1342       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1354   1373       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1409   1430       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      128    419       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      500    721       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      870   1138       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1188   1437       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1446   1506       GPHH. {ECO:0000259|Pfam:PF16905}.
SQ   SEQUENCE   1575 AA;  180115 MW;  9E775D0B856DAE75 CRC64;
     TASLLPPVGT DFLRPLTSAS LGPMNQRVKR QRQKGNKDEQ RVTNNDLPQP SPELEEGRPL
     PYIFGEPSAE HLNTPLEELD PYHQSEKTFL VLGKGKVIHR FNAHKACYLF GPLNPLRTLA
     IKILTLNTLF SALMFVTILL NYVVMVTLRY SSPLNLYAGF AFSAVFMLEV LVKILSRGLC
     IGKFTFLRNP WNWPDVTVIA APFLSLFVHL PMLLEVSLLL KMIPIFPGLK KMLYHFVQSV
     KRLSCVLILT AFMLCIFATV GLQSFMGNLR QKCISTSLFS QNRTSDIYIT SYYVNESTAF
     NYQEYIDDPD NIYFLPGSLD ALVCGNSSDA GTCPEGYMCI RAGRTPNYSY TSYDTFGWSL
     LSSFRLLTQE YWENLMQLVL RSAGKFSLVH FLFFVSPGCF VLVSLIVAVA AAAVCELEQL
     RAAEASRKEK EFRQIVKALK RREEEEVKRR WHHPHQYPHW NANHAWSPRC SAAAQLLLRW
     NCCGCWRWLK QRVRTIVTSP FFDLGIVVCI VIDVLFMAME HFPMTEEFQQ TLTCANLVFT
     CIYTVEMVIK IVAMDPYGYF KVSWNTFECT IVAVSLLELC VADVEGLSVL RVFRLLRVFR
     LARSWRWFHQ FLQITLKFSF LLLIVLLGFV TVGYQLFHRD YRTSVCKISH DCSLPRWHMD
     SFFHTFLIVF GIFSGSWIES LWDCMEVSGP TLCLTFYLSA VIIGNLLVLH LFLVLLLNPY
     SSNVVSPGEG DKNSVEIALG WCKTWILEHT CPSLGGRDKT QTAAVSQGPS QQAYVALDMV
     ATEKLHSDET KLKKLDEDSP KQDGMEPRER EVLRDQDGEE PEDTPENCCC QRCYSCCPLL
     NTDPSQGAGR LCFSSRKICL LIVQNRHVKR FMTVVVLLSS VALALEDVYL QHRPVLRTVL
     SAAELAFGAL FLVEMLLKWV GFGFRKYFTN AWCWLEFLIV AVGAPQTPGK PPILGSRVLL
     QPAGLGTLRV LRVLRILSIF QGPRLVLGTL FQLVPAMFGG LLVILLVWLV FSVVGVNMFA
     GKFYYCLNET SQEMFLSEEV QTKSECYALI FSNYTEVTWK NSPFTFDNVL MGYLSLFVMG
     FSKSWRDIMY AAVDSRFVES QPVYEYDPYK WLYFVFFIIN VFFTLNFFIK VILSALQRKP
     GDEHIFMTKH QQIYSKTWMK LFPKSPQRAV PRPQNKCQAC VFDLVNSPIY EVVMVALICL
     SVVLLMVESM DLTLGLEIVL HWLHFIYVLI FLIECILKIV ALRQHYFKDG WNIIDFIVLL
     VQIIAIFMFD FFYAYFISPT IFLLLRLFRI TRVLHFIPWT RRIRKLLLAF GKSLPALFNI
     AFVLFVTMVV YSLIGMFNFA YVKEEFTIDD FFNFETFCSS FICMFMSSTT TAWDGLLLPI
     MSRPPSCDPF AEHPGSDVIG DCSSPTLGIA FFSTYLLLTF LLLIQLYIAV ALEIINSEDT
     EGLSDIDLQR FCNTWKRFDP DGTDLIPYSK LCDFSDSLQD PLGIPHPNTS RLAHMDLPLY
     PGDKVHCTDV LLSLAKQVLD DPEEVESLKT RMQKQLKAKE NGGGSSQVLG EPVSSTLRRR
     REERAAKVIQ RAFRK
//
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