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Database: UniProt
Entry: H2STE1_TAKRU
LinkDB: H2STE1_TAKRU
Original site: H2STE1_TAKRU 
ID   H2STE1_TAKRU            Unreviewed;      1701 AA.
AC   H2STE1;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 36.
DE   SubName: Full=Sodium channel, voltage-gated, type IV, alpha, b {ECO:0000313|Ensembl:ENSTRUP00000015678};
GN   Name=LOC101062543 {ECO:0000313|Ensembl:ENSTRUP00000015678};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000015678, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000015678}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000015678}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000015678}.
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DR   Ensembl; ENSTRUT00000015747; ENSTRUP00000015678; ENSTRUG00000006408.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028809; Na_channel_a10su.
DR   PANTHER; PTHR10037:SF208; PTHR10037:SF208; 3.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    123    145       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    157    176       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    197    221       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    241    263       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    392    415       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    575    593       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    605    625       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    688    711       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    736    756       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    768    791       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1112   1137       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1237   1255       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1315   1333       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1345   1367       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1379   1401       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1446   1468       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1480   1499       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1535   1556       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      129    420       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      574    795       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1002   1264       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1314   1563       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1572   1632       GPHH. {ECO:0000259|Pfam:PF16905}.
SQ   SEQUENCE   1701 AA;  192796 MW;  F53D08715C43E39A CRC64;
     TASLLPPVGT DFLRPLTSAS LGPMNQRVKR QRQKGNKDEQ RVTNNDLPQP SPELEEGRPL
     PYIFGEPSAE HLNTPLEELD PYHQSEKTFL VLGKGKVIHR FNAHKACYLF GPLNPLRTLA
     IKILTNLNTL FSALMFVTIL LNYVVMVTLR YSSPLNLYAG FAFSAVFMLE VLVKILSRGL
     CIGKFTFLRN PWNWPDVTVI AAPFLSLFVH LPMLLEVSLL LKMIPIFPGL KKMLYHFVQS
     VKRLSCVLIL TAFMLCIFAT VGLQSFMGNL RQKCISTSLF SQNRTSDIYI TSYYVNESTA
     FNYQEYIDDP DNIYFLPGSL DALVCGNSSD AGTCPEGYMC IRAGRTPNYS YTSYDTFGWS
     LLSSFRLLTQ EYWENLMQLV LRSAGKFSLV HFLFFVSPGC FVLVSLIVAV AAAAVCELEQ
     LRAAEASRKE KEFRQIVKAL KRREEEEVKR RWHHPHQYPH WNANHACTCT PQAAGKAAKS
     EGPDEDSKKS QEQQQTGKGK NCQSCSGEPR RRLTADASHA DCMAALSCTS VPEAEPQTSG
     SPRCSAAAQL LLRWNCCGCW RWLKQRVRTI VTSPFFDLGI VVCIVIDVLF MAMEHFPMTE
     EFQQTLTCAN LVFTCIYTVE MVIKIVAMDP YGYFKVSWNT FECTIVAVSL LELCVADVEG
     LSVLRVFRLL RVFRLARSWR WFHQFLQITL KFSFLLLIVL LGFVTVGYQL FHRDYRTSVC
     KISHDCSLPR WHMDSFFHTF LIVFGIFSGS WIESLWDCME VSGPTLCLTF YLSAVIIGNL
     LVLHLFLVLL LNPYSSNVVS PGEGDKNSVE IALGWCKTWI LEHTCPSLGG RDKTQTGAVS
     FPSVVQPITA VQDGPEDRNL AAVSQGPSQQ AYVALDMVAT EKLHSDETKL KKLDEDSPKV
     NLSNLCHNVA ISSRVNWTMS SAGRDGAEGE RSPPGPGWRG ARGHSGELLL PEPGGDPRVC
     VCVWCYSCCP LLNTDPSQGA GRLCFSSRKI CLLIVQNRHV KRFMTVVVLL SSVALALEDV
     YLQHRPVLRT VLSAAELAFG ALFLVEMLLK WVGFGFRKYF TNAWCWLEFL IVAASRPQVF
     SSGVLLQPAG LGTLRVLRVL RILSIFQGPR LVLGTLFQLV PAMFGGLLVI LLVWLVFSVV
     GVNMFAGKFY YCLNETSQEM FLSEEVQTKS ECYALIFSNY TEVTWKNSPF TFDNVLMGYL
     SLFVMGFSKS WRDIMYAAVD SRFVESQPVY EYDPYKWLYF VFFIINVFFT LNFFIKVILS
     ALQRKPGDEH IFMTKHQQIY SKTWMKLFPK SPQRAVPRPQ NKCQACVFDL VNSPIYEVVM
     VALICLSVVL LMVESMDLTL GLEIVLHWLH FIYVLIFLIE CILKIVALRQ HYFKDGWNII
     DFIVLLVQII AIFMFDFFYA YFISPTIFLL LRLFRITRVL HFIPWTRRIR KLLLAFGKSL
     PALFNIAFVL FVTMVVYSLI GMFNFAYVKE EFTIDDFFNF ETFCSSFICM FMSSTTTAWD
     GLLLPIMSRP PSCDPFAEHP GSDVIGDCSS PTLGIAFFST YLLLTFLLLI QLYIAVALEI
     INSEDTEGLS DIDLQRFCNT WKRFDPDGTD LIPYSKLCDF SDSLQDPLGI PHPNTSRLAH
     MDLPLYPGDK VHCTDVLLSL AKQVLDDPEE VESLKTRMQK QLKAKENGGG SSQVLGEPVS
     STLRRRREER AAKVIQRAFR K
//
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