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Database: UniProt
Entry: H2STE2_TAKRU
LinkDB: H2STE2_TAKRU
Original site: H2STE2_TAKRU 
ID   H2STE2_TAKRU            Unreviewed;      1685 AA.
AC   H2STE2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   20-DEC-2017, entry version 37.
DE   SubName: Full=Sodium channel, voltage-gated, type IV, alpha, b {ECO:0000313|Ensembl:ENSTRUP00000015679};
GN   Name=LOC101062543 {ECO:0000313|Ensembl:ENSTRUP00000015679};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000015679, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000015679}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000015679}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000015679}.
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DR   Ensembl; ENSTRUT00000015748; ENSTRUP00000015679; ENSTRUG00000006408.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0019233; P:sensory perception of pain; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028809; Na_channel_a10su.
DR   PANTHER; PTHR10037:SF208; PTHR10037:SF208; 3.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    122    144       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    156    175       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    196    220       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    240    262       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    391    414       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    561    579       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    674    697       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    722    742       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    754    777       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    989   1008       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1020   1040       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1052   1075       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1095   1121       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1221   1239       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1299   1317       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1329   1351       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1363   1385       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1430   1452       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1464   1483       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1519   1540       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      128    419       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      560    781       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      988   1248       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1298   1547       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1556   1616       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED      422    442       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1685 AA;  192124 MW;  E0C04F612A10A832 CRC64;
     ASLLPPVGTD FLRPLTSASL GPMNQRVKRQ RQKGNKDEQR VTNNDLPQPS PELEEGRPLP
     YIFGEPSAEH LNTPLEELDP YHQSEKTFLV LGKGKVIHRF NAHKACYLFG PLNPLRTLAI
     KILTNLNTLF SALMFVTILL NYVVMVTLRY SSPLNLYAGF AFSAVFMLEV LVKILSRGLC
     IGKFTFLRNP WNWPDVTVIA APFLSLFVHL PMLLEVSLLL KMIPIFPGLK KMLYHFVQSV
     KRLSCVLILT AFMLCIFATV GLQSFMGNLR QKCISTSLFS QNRTSDIYIT SYYVNESTAF
     NYQEYIDDPD NIYFLPGSLD ALVCGNSSDA GTCPEGYMCI RAGRTPNYSY TSYDTFGWSL
     LSSFRLLTQE YWENLMQLVL RSAGKFSLVH FLFFVSPGCF VLVSLIVAVA AAAVCELEQL
     RAAEASRKEK EFRQIVKALK RREEEEVKRR WHHPHQYPHW NANHACTCTP QAAGKAAKSE
     GPDEDSKKSQ EQQQTGKGKN CQSCSGEPRR RLTADASHEA EPQTSGSPRC SAAAQLLLRW
     NCCGCWRWLK QRVRTIVTSP FFDLGIVVCI VIDVLFMAME HFPMTEEFQQ TLTCANLVFT
     CIYTVEMVIK IVAMDPYGYF KVSWNTFECT IVAVSLLELC VADVEGLSVL RVFRLLRVFR
     LARSWRWFHQ FLQITLKFSF LLLIVLLGFV TVGYQLFHRD YRTSVCKISH DCSLPRWHMD
     SFFHTFLIVF GIFSGSWIES LWDCMEVSGP TLCLTFYLSA VIIGNLLVLH LFLVLLLNPY
     SSNVVSPGEG DKNSVEIALG WCKTWILEHT CPSLGGRDKT QTGWARGQEV GDSLNLILHG
     LNGHIYVFDQ ENLWRLFTFW RLSFLLAAVS QGPSQQAYVA LDMVATEKLH SDETKLKKLD
     EDSPKVNLSN LCHNVAISSR DGMEPREREV LRDQDGEEPE DTPENCCCQR CYSCCPLLNT
     DPSQGAGRLC FSSRKICLLI VQNRHVKRFM TVVVLLSSVA LALEDVYLQH RPVLRTVLSA
     AELAFGALFL VEMLLKWVGF GFRKYFTNAW CWLEFLIVAV AGVSPTGVLL QPAGLGTLRV
     LRVLRILSIF QGPRLVLGTL FQLVPAMFGG LLVILLVWLV FSVVGVNMFA GKFYYCLNET
     SQEMFLSEEV QTKSECYALI FSNYTEVTWK NSPFTFDNVL MGYLSLFVMG FSKSWRDIMY
     AAVDSRFVES QPVYEYDPYK WLYFVFFIIN VFFTLNFFIK VILSALQRKP GDEHIFMTKH
     QQIYSKTWMK LFPKSPQRAV PRPQNKCQAC VFDLVNSPIY EVVMVALICL SVVLLMVESM
     DLTLGLEIVL HWLHFIYVLI FLIECILKIV ALRQHYFKDG WNIIDFIVLL VQIIAIFMFD
     FFYAYFISPT IFLLLRLFRI TRVLHFIPWT RRIRKLLLAF GKSLPALFNI AFVLFVTMVV
     YSLIGMFNFA YVKEEFTIDD FFNFETFCSS FICMFMSSTT TAWDGLLLPI MSRPPSCDPF
     AEHPGSDVIG DCSSPTLGIA FFSTYLLLTF LLLIQLYIAV ALEIINSEDT EGLSDIDLQR
     FCNTWKRFDP DGTDLIPYSK LCDFSDSLQD PLGIPHPNTS RLAHMDLPLY PGDKVHCTDV
     LLSLAKQVLD DPEEVESLKT RMQKQLKAKE NGGGSSQVLG EPVSSTLRRR REERAAKVIQ
     RAFRK
//
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