GenomeNet

Database: UniProt
Entry: H2SUL6_TAKRU
LinkDB: H2SUL6_TAKRU
Original site: H2SUL6_TAKRU 
ID   H2SUL6_TAKRU            Unreviewed;      2399 AA.
AC   H2SUL6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 38.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=cacna1b {ECO:0000313|Ensembl:ENSTRUP00000016103};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000016103, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000016103}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000016103}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000016103}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 31033.ENSTRUP00000016103; -.
DR   Ensembl; ENSTRUT00000016175; ENSTRUP00000016103; ENSTRUG00000006562.
DR   eggNOG; ENOG410INF8; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; H2SUL6; -.
DR   OMA; FREDNLI; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 2.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    100    117       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    138    159       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    171    191       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    226    248       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    302    323       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    335    357       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    501    520       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    626    648       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    704    726       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1158   1176       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1196   1216       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1228   1247       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1289   1311       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1401   1426       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1482   1500       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1512   1534       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1604   1622       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1693   1716       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1732   1767       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      722    749       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2399 AA;  270836 MW;  93D121735711C9B1 CRC64;
     MARFAEDLPT RYGGSAGGGG RGGPGTGRGG ARAGGAAPGG QRVYKQSMAQ RARTMAIYNP
     NPVKQNCLTV NRSLFIFRED NLIRKYAKRI TEWPYLYTPF EYMILATIIA NCIVLALEQH
     LPASDKTPMS ERLDDTEPYF IGIFCFEAAI KIIALGFAFH KGSYLRNGWN VMDFVVVLSG
     ILATVGSDFD LRTLRAVRVL RPLKLVSGIP SLQVVLKSIM KAMVPLLQIG LLLFFAIVMF
     AIIGVEFYMG KFHTTCFRTD TGEKAADWSC GQEPPARICP NGTECREYWT GPNFGITNFD
     NILFAILTVF QCITMEGWVD ILYSTNNVAG NTWNWLYFIP LIIIGSFFML NLVLGVLSGE
     FAKERERVEK RQEFLKLRRQ QQIERELTGY LEWICKAEEV LLEEEDEIAD EKSPLDGAWY
     KRTQNLSVLK RNKAKKGKND LIGAEEGEDP FADISSVAPP GSPFGRASVK SSGKMDSSSY
     FRRKEKRVRF FIRRMVKAQS FYWIVLCVVG LNTLCVAIVH YDQPEWLTKA LYTAEFVFLG
     LFLTEMTLKM YGLGVRNYFH SSFNCFDFGV IVGSICEVIW DMITPGASFG ISVLRALRLL
     RIFKVTKYWN SLRNLVISLL NSMKSIISLL FLLFLFIVVF ALLGMQLFGG QFNFEDETPT
     TNFDTFPAAI LTVFQILTGE DWNAVMYHGI ESQGGVRRGM FSSVYFIVLT LFGNYTLLNV
     FLAIAVDNLA NAQELTKDEE EQEEAANKKL ALQKALEVKE VSPMSAANIS IAAFVKQNRD
     ALSRRSSINS IQSPKEQQRT AKTMSVWEQR TNQLRRHNMR ASSEALFNEL DPEERRRMST
     ALHLHPDMKT HLDRPLIVED RGGDKPARTP EGGHLESDHE GHSRKHHRHR DRNGENREGC
     DGRGGRHHTH HSRSRDHNGN GSQSKERRGE RSHSRNGGQG HRHHHHHHNG SPEEEANDVR
     GGEERVHRHH HSHRPPKEGN GTIANGSQGD RKGKCGGGDS NGERKGHCSH VRAQPAGDGD
     DFKKNKNGNQ SHWEKTPDAQ EDGLASTPLQ AMRGGLTAGE KQEDADNLKN STRASQAGLN
     SNAIHIPVTI TAPPGETTLI PMNNIDCESF QIREEKKNLE EAEEVNGPRQ MLPYSSMFIF
     GQTNPVRRLC HYVVNLRYFE MCILIVITMS SIALAAEDPV QANAPRNNVL KYLDYVFTGV
     FTFEMVIKMI DLGLLLHPGS YFRDLWNILD FIVVSGALVA FACSGTKGKD INTIKSLRVL
     RVLRPLKTIK RLPKLKAVFD CVVNSLKNVL NILIVYILFM FIFAVIAVQL FKGKFFYCTD
     ESKVLEKDCR GHFLEYDKDH VTAQPREWKK YDFHYDNVLW AFLTLFTVST GEGWPMVLKH
     SVDATYEDQG PNPGFRMETS IFYVVYFVVF PFFFVNIFVA LIIITFQEQG DKAMSECSLE
     KNERACIDFA INAKPLTRYM PENKLSFQYK MWKFVVSPPF EYAIMTLIAL NTVVLMMKFY
     GAPDLYESML KYLNIVFTAL FTLECILKII AFGPLNYLKA AWNVFDFVTV LGSITDILVT
     EVKTDKMINL SFLRLFRAAR LIKLLRQGYT IRILLWTFVQ SFKALPYVCL LIAMLFFIYA
     IIGMQVFGNI ELIEESAIHR HNNFQTFFQA LTLLFRSATG EAWHEIMLAC LSNRPCDKLS
     GTVGNECGSD FAYFYFVSFI FLCSFLMLNL FVAVIMDNFE YLTRDASILG PHHLDEFIRV
     WAEYDPAACG RITYRDMYEM LRDMSPPLGL GKKCPPRIAY KRLVKMNMPI ADDNTVHFTS
     TLMALIRTAL EIKLASGVLV QRLYDADLKR EISRVWPSLP QKTIDLLVTP HKYSVESRNL
     HSYTVFYNEL TVGKVYAALM IFDYYKQNRA KRLQQQQQSS TGPQSKLGAL FRPMLPFTHI
     REPPLTSPIQ PPKPQPEPET KPDTLATTST TLGTTVTATA TTSTTRDSVG DVSQATQRLK
     GRKKLQRGLS EDVPYCTRPQ ESVELKQVDN ISDTDEYLSL DGHGRAASLP RLNAEYYRSH
     PRHAPGTHLA PIVDLSPIRR SASSLTQHHQ DVRLKDFDLE RPDLAQSLMG AGQVRSQDRS
     HHHHHHHRCH RRRDRDKEKK QKSIDRPVQP SSTVDSFTDP SAQGLSRERA RERDRSRPHE
     RRHHSSAGEK QRYYSCERYS SREQCHTKSA GPSRSTSPGE GQEVAFLKQY GSTVVKAGPV
     MLPSGSTTPG RGRRQLPQTP LTPRPAVTYK SAHPSTLPSS LSTTMTGHQT RFSRGLSEHE
     RLVGVQGETL MPITCIGSDP NLNRHPEVAP QQDLLEETED YHDTVSSHGV VCTARTTPVS
     TTASVSQGTA AAPITSPPRQ GRAGAMPNGY HFTLGVNSAS GSGSRGTGSL REREEEDWC
//
DBGET integrated database retrieval system