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Database: UniProt
Entry: H2SUL8_TAKRU
LinkDB: H2SUL8_TAKRU
Original site: H2SUL8_TAKRU 
ID   H2SUL8_TAKRU            Unreviewed;      2356 AA.
AC   H2SUL8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 38.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=cacna1b {ECO:0000313|Ensembl:ENSTRUP00000016105};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000016105, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000016105}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000016105}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000016105}.
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DR   Ensembl; ENSTRUT00000016177; ENSTRUP00000016105; ENSTRUG00000006562.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 2.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    100    117       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    138    159       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    171    191       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    226    248       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    302    323       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    335    357       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    491    510       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    616    638       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    694    716       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1147   1165       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1185   1205       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1217   1236       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1278   1300       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1390   1415       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1471   1489       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1501   1523       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1592   1610       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1681   1704       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1841   1875       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      712    739       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2356 AA;  266170 MW;  BF7CE394935C9C17 CRC64;
     MARFAEDLPT RYGGSAGGGG RGGPGTGRGG ARAGGAAPGG QRVYKQSMAQ RARTMAIYNP
     NPVKQNCLTV NRSLFIFRED NLIRKYAKRI TEWPYLYTPF EYMILATIIA NCIVLALEQH
     LPASDKTPMS ERLDDTEPYF IGIFCFEAAI KIIALGFAFH KGSYLRNGWN VMDFVVVLSG
     ILATVGSDFD LRTLRAVRVL RPLKLVSGIP SLQVVLKSIM KAMVPLLQIG LLLFFAIVMF
     AIIGVEFYMG KFHTTCFRTD TGEKAADWSC GQEPPARICP NGTECREYWT GPNFGITNFD
     NILFAILTVF QCITMEGWVD ILYSTNNVAG NTWNWLYFIP LIIIGSFFML NLVLGVLSGE
     FAKERERVEK RQEFLKLRRQ QQIERELTGY LEWICKAEEV LLEEEDEIAD EKSPLDAVLK
     RNKAKKGKND LIGAEEGEDP FADISSVAPP GSPFGRASVK SSGKMDSSSY FRRKEKRVRF
     FIRRMVKAQS FYWIVLCVVG LNTLCVAIVH YDQPEWLTKA LYTAEFVFLG LFLTEMTLKM
     YGLGVRNYFH SSFNCFDFGV IVGSICEVIW DMITPGASFG ISVLRALRLL RIFKVTKYWN
     SLRNLVISLL NSMKSIISLL FLLFLFIVVF ALLGMQLFGG QFNFEDETPT TNFDTFPAAI
     LTVFQILTGE DWNAVMYHGI ESQGGVRRGM FSSVYFIVLT LFGNYTLLNV FLAIAVDNLA
     NAQELTKDEE EQEEAANKKL ALQKALEVKE VSPMSAANIS IAAKEQQRTA KTMSVWEQRT
     NQLRRHNMRA SSEALFNELD PEERRRMSTA LHLHPDMKTH LDRPLIVEDR GGDKPARTPE
     GGHLESDHEG HSRKHHRHRD RNGENREGCD GRGGRHHTHH SRSRDHNGNG SQSKERRGER
     SHSRNGGQGH RHHHHHHNGS PEEEANDVRG GEERVHRHHH SHRPPKEGNG TIANGSQGDR
     KGKCGGGDSN GERKGHCSHV RAQPAGDGDD FKKNKNGNQS HWERLEAESD HVCDEINISL
     PREKTPDAQE DGLASTPLQA MRGGLTAGEK QEDADNLKNS TRASQAGLNS NAIHIPVTIT
     APPGETTLIP MNNIDCESFQ IREEKKNLEE AEEVNGPRQM LPYSSMFIFG QTNPVRRLCH
     YVVNLRYFEM CILIVITMSS IALAAEDPVQ ANAPRNNVLK YLDYVFTGVF TFEMVIKMID
     LGLLLHPGSY FRDLWNILDF IVVSGALVAF ACSGTKGKDI NTIKSLRVLR VLRPLKTIKR
     LPKLKAVFDC VVNSLKNVLN ILIVYILFMF IFAVIAVQLF KGKFFYCTDE SKVLEKDCRG
     HFLEYDKDHV TAQPREWKKY DFHYDNVLWA FLTLFTVSTG EGWPMVLKHS VDATYEDQGP
     NPGFRMETSI FYVVYFVVFP FFFVNIFVAL IIITFQEQGD KAMSECSLEK NERACIDFAI
     NAKPLTRYMP ENKLSFQYKM WKFVVSPPFE YAIMTLIALN TVVLMMKFYG APDLYESMLK
     YLNIVFTALF TLECILKIIA FGPLNYLKAA WNVFDFVTVL GSITDILVTE VKDKMINLSF
     LRLFRAARLI KLLRQGYTIR ILLWTFVQSF KALPYVCLLI AMLFFIYAII GMQVFGNIEL
     IEESAIHRHN NFQTFFQALT LLFRSATGEA WHEIMLACLS NRPCDKLSGT VGNECGSDFA
     YFYFVSFIFL CSFLMLNLFV AVIMDNFEYL TRDASILGPH HLDEFIRVWA EYDPAACGRI
     CYQDMYKLLL FISPPLGLGK KCPNRVAYKR LVKMNMPIAD DNTVHFTSTL MALIRTALEI
     KLASGVLVQR LYDADLKREI SRVWPSLPQK TIDLLVTPHK YNELTVGKVY AALMIFDYYK
     QNRAKRLQQQ QQSSTGPQSK LGALFRPMLP FTHIREPPLT SLFAVLQQVS CQCSSLCSCV
     YRQTRRSAIK HSQSGDVSQA TQRLKGRKKL QRGLSEDVPY CTRPQESVEL KQVDNISDTD
     EYLSLDGHGR AASLPRLNAE YYPIVDLSPI RRSASSLTQH HQDVRLKDFD LERPDLAQSL
     MGAGQVRSQD RSHHHHHHHR CHRRRDRDKE KKQKSIDRPV QPSSTVGEEV QDSFTDPSAQ
     GLSRERARER DRSRPHERRH HSSAGEKQRY YSCERYSSRE QCHTKSAGPS RSTSPGEGQE
     VAFLKQYGST VVKAGPVMLP SGSTTPGRGR RQLPQTPLTP RPAVTYKSAH PSTLPSSLST
     TMTGHQTRFS RGLSEHERLV GVQGETLMPI TCIGSDPNLN RHPEVAPQQD LLEETEDYHD
     TVSSHGVVCT ARTTPVSTTA SVSQGTAAAP ITSPPRQGRA GAMPNGYHFT LGVNSASGSG
     SRGTGSLRER EEEDWC
//
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