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Database: UniProt
Entry: H2SUM0_TAKRU
LinkDB: H2SUM0_TAKRU
Original site: H2SUM0_TAKRU 
ID   H2SUM0_TAKRU            Unreviewed;      2315 AA.
AC   H2SUM0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 38.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=cacna1b {ECO:0000313|Ensembl:ENSTRUP00000016107};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000016107, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000016107}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000016107}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000016107}.
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DR   Ensembl; ENSTRUT00000016179; ENSTRUP00000016107; ENSTRUG00000006562.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 2.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    100    117       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    138    159       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    171    191       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    226    248       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    302    323       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    335    357       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    491    510       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    616    638       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    694    716       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1146   1164       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1184   1204       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1216   1235       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1277   1299       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1389   1414       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1470   1488       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1500   1522       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1591   1609       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1680   1703       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1840   1874       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      712    739       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2315 AA;  261655 MW;  EBB3811969161885 CRC64;
     MARFAEDLPT RYGGSAGGGG RGGPGTGRGG ARAGGAAPGG QRVYKQSMAQ RARTMAIYNP
     NPVKQNCLTV NRSLFIFRED NLIRKYAKRI TEWPYLYTPF EYMILATIIA NCIVLALEQH
     LPASDKTPMS ERLDDTEPYF IGIFCFEAAI KIIALGFAFH KGSYLRNGWN VMDFVVVLSG
     ILATVGSDFD LRTLRAVRVL RPLKLVSGIP SLQVVLKSIM KAMVPLLQIG LLLFFAIVMF
     AIIGVEFYMG KFHTTCFRTD TGEKAADWSC GQEPPARICP NGTECREYWT GPNFGITNFD
     NILFAILTVF QCITMEGWVD ILYSTNNVAG NTWNWLYFIP LIIIGSFFML NLVLGVLSGE
     FAKERERVEK RQEFLKLRRQ QQIERELTGY LEWICKAEEV LLEEEDEIAD EKSPLDAVLK
     RNKAKKGKND LIGAEEGEDP FADISSVAPP GSPFGRASVK SSGKMDSSSY FRRKEKRVRF
     FIRRMVKAQS FYWIVLCVVG LNTLCVAIVH YDQPEWLTKA LYTAEFVFLG LFLTEMTLKM
     YGLGVRNYFH SSFNCFDFGV IVGSICEVIW DMITPGASFG ISVLRALRLL RIFKVTKYWN
     SLRNLVISLL NSMKSIISLL FLLFLFIVVF ALLGMQLFGG QFNFEDETPT TNFDTFPAAI
     LTVFQILTGE DWNAVMYHGI ESQGGVRRGM FSSVYFIVLT LFGNYTLLNV FLAIAVDNLA
     NAQELTKDEE EQEEAANKKL ALQKALEVKE VSPMSAANIS IAAKEQQRTA KTMSVWEQRT
     NQLRRHNMRA SSEALFNELD PEERRRMSTA LHLHPDMKTH LDRPLIVEDR GGDKPARTPE
     GGHLESDHEG HSRKHHRHRD RNGENREGCD GRGGRHHTHH SRSRDHNGNG SQSKERRGER
     SHSRNGGQGH RHHHHHHNGS PEEEANDVRG GEERVHRHHH SHRPPKEGNG TIANGSQGDR
     KGKCGGGDSN GERKGHCSHV RAQPAGDGDD FKKNKNDAFW RERLEAESDH VCDEINISLP
     REKTPDAQED GLASTPLQAM RGGLTAGEKQ EDADNLKNST RASQAGLNSN AIHIPVTITA
     PPGETTLIPM NNIDCESFQI REEKKNLEEA EEVNGPRQML PYSSMFIFGQ TNPVRRLCHY
     VVNLRYFEMC ILIVITMSSI ALAAEDPVQA NAPRNNVLKY LDYVFTGVFT FEMVIKMIDL
     GLLLHPGSYF RDLWNILDFI VVSGALVAFA CSGTKGKDIN TIKSLRVLRV LRPLKTIKRL
     PKLKAVFDCV VNSLKNVLNI LIVYILFMFI FAVIAVQLFK GKFFYCTDES KVLEKDCRGH
     FLEYDKDHVT AQPREWKKYD FHYDNVLWAF LTLFTVSTGE GWPMVLKHSV DATYEDQGPN
     PGFRMETSIF YVVYFVVFPF FFVNIFVALI IITFQEQGDK AMSECSLEKN ERACIDFAIN
     AKPLTRYMPE NKLSFQYKMW KFVVSPPFEY AIMTLIALNT VVLMMKFYGA PDLYESMLKY
     LNIVFTALFT LECILKIIAF GPLNYLKAAW NVFDFVTVLG SITDILVTEV KDKMINLSFL
     RLFRAARLIK LLRQGYTIRI LLWTFVQSFK ALPYVCLLIA MLFFIYAIIG MQVFGNIELI
     EESAIHRHNN FQTFFQALTL LFRSATGEAW HEIMLACLSN RPCDKLSGTV GNECGSDFAY
     FYFVSFIFLC SFLMLNLFVA VIMDNFEYLT RDASILGPHH LDEFIRVWAE YDPAACGRIC
     YQDMYKLLLF ISPPLGLGKK CPNRVAYKRL VKMNMPIADD NTVHFTSTLM ALIRTALEIK
     LASGVLVQRL YDADLKREIS RVWPSLPQKT IDLLVTPHKY NELTVGKVYA ALMIFDYYKQ
     NRAKRLQQQQ QSSTGPQSLF AVLQQVSCQC SSLCSCVYRQ TRRSAIKHSQ SGDVSQATQR
     LKGRKKLQRG LSEDVPYCTR PQESVELKQV DNISDTDEYL SLDGHGRAAS LPRLNAEYYP
     IVDLSPIRRS ASSLTQHHQD VRLKDFDLER PDLAQSLIHH HHHRCHRRRD RDKEKKQKSI
     DRPVQPSSTV DSFTDPSAQG LSRERARERD RSRPHERRHH SSAGEKQRYY SCERYSSREQ
     CHTKSAGPSR STSPGEGQEV AFLKQYGSTV VKAGPVMLPS GSTTPGRGRR QLPQTPLTPR
     PAVTYKSAHP STLPSSLSTT MTGHQTRFSR GLSEHERLVG VQGETLMPIT CIGSDPNLNR
     HPEVAPQQDL LEETEDYHDT VSSHGVVCTA RTTPVSTTAS VSQGTAAAPI TSPPRQGRAG
     AMPNGYHFTL GVNSASGSGS RGTGSLRERE EEDWC
//
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