ID H2SVD9_TAKRU Unreviewed; 727 AA.
AC H2SVD9;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Two pore segment channel 2 {ECO:0000313|Ensembl:ENSTRUP00000016377.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000016377.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000016377.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000016377.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2SVD9; -.
DR STRING; 31033.ENSTRUP00000016377; -.
DR Ensembl; ENSTRUT00000016449.3; ENSTRUP00000016377.3; ENSTRUG00000028617.1.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000159763; -.
DR HOGENOM; CLU_019500_2_0_1; -.
DR InParanoid; H2SVD9; -.
DR OMA; FTESIEM; -.
DR TreeFam; TF328550; -.
DR Proteomes; UP000005226; Chromosome 13.
DR GO; GO:0005765; C:lysosomal membrane; IEA:InterPro.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0022832; F:voltage-gated channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028798; TPC2.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46768; TWO PORE CALCIUM CHANNEL PROTEIN 2; 1.
DR PANTHER; PTHR46768:SF1; TWO PORE CHANNEL PROTEIN 2; 1.
DR Pfam; PF00520; Ion_trans; 2.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 408..431
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 443..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 507..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 648..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 114..308
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 432..673
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
SQ SEQUENCE 727 AA; 83383 MW; 6C30E1448D01C5EA CRC64;
SSSSSSSSSS SSSSSSSTST FVLLNLFSYF TLHANANVLH FVPCVTVVFV SRLLQYRSIN
HRVDVRSLRL YRCYYSTLCQ WCLGLTIAVV LLLAFVERPS SLSLSSDPRR RSTHLNPPCG
ATESVELVCL VVFALDLAVK SYLIGWDEFR KNKWLIGYLV VISVSVIDWM LSVSMMCDER
LRVRRLLRPF FLLQNSSLMK KTLKCIKRTL PEIASVILLL ALHLCLFTMI GMLLFAKTEK
NEEWNLHFRN LPTALTSLLV LLTTANNPDV MLPAYSLNRS YAIFFMAFSV IGTYCLMNLL
TAIIYNQFRG YLLMSVQTSI IRRRLGIRAA FQVLSCLGDQ TGPEPHLRTC HHLCSQEVQQ
FADVGYLDRE QFTKIFDHLD TDRIKEHPPV PQYNSQLLQR LQQIFSHYYL TILGNLVALA
NVLCIGAVLV LNADKSVADR DNVVMQIINL CFILFYLFEM CVKIFAFGLR GYLSYRSNIF
DGFLTVLLLV TPLLHRVCSR DPTVTEVLSL WDMISFINML IVFRFLRIIP NIKLMALVAS
TLLDLVKNLR AFAGILVVVY YVYAVFGIWL FEGVIKPPPE ILLSNQTQEN GTSNFSSECG
TYEQLGYWPN NFDDFAASII LLYDVMIVNN WQAFLDAYSR YTTGWSKIYF VCWWLTSSVM
WVNLFVALIL ENFIYRWDRS HSCSNTDVER IRYETSVQLI FKSQVQEPTE EELLCQLHKH
PHLNLQG
//
