ID H2SWM4_TAKRU Unreviewed; 654 AA.
AC H2SWM4; H2SWM2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Epidermal growth factor receptor kinase substrate 8-like {ECO:0000313|Ensembl:ENSTRUP00000016812.2};
GN Name=LOC101074624 {ECO:0000313|Ensembl:ENSTRUP00000016812.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000016812.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000016812.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000016812.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the EPS8 family.
CC {ECO:0000256|ARBA:ARBA00006197}.
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DR RefSeq; XP_011620262.1; XM_011621960.1.
DR AlphaFoldDB; H2SWM4; -.
DR STRING; 31033.ENSTRUP00000016812; -.
DR Ensembl; ENSTRUT00000016885.3; ENSTRUP00000016812.2; ENSTRUG00000006845.3.
DR GeneID; 101074624; -.
DR KEGG; tru:101074624; -.
DR CTD; 393332; -.
DR GeneTree; ENSGT00940000158169; -.
DR HOGENOM; CLU_014510_0_0_1; -.
DR InParanoid; H2SWM4; -.
DR OMA; LGDSWNI; -.
DR OrthoDB; 2997036at2759; -.
DR Proteomes; UP000005226; Chromosome 3.
DR CDD; cd01210; PTB_EPS8; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR039801; EPS8-like.
DR InterPro; IPR033928; EPS8_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041418; SAM_3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12287:SF22; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 3; 1.
DR PANTHER; PTHR12287; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF18016; SAM_3; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 500..559
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..461
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 558..576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 654 AA; 74872 MW; 561873704AFE478B CRC64;
MFRQSRPFSY SPSFRGFSQE DYPQQRRPTH HDDFRGAPVQ RNGMFRPNGK SIYRQRKDYS
ETLSRESETH FRVEHLLTCE LDGQELKTLD NCMSKLKRLD GKGRLWPQQM IMEVHRGYLV
LSDIETKVEL EAIPLRWVLE AKAVLDSCAY NSVLIITVDE RNKRSPQVYM FQCEETGAEV
IKADLDKVID YRSGPTRNED IVEPAKAQPD IKINLENIIG KHFRQPESFI MPQEKNPPLD
FPPPQWREPD MLPPPRPYSP QDYFTRSLDV QDPRRSPEAP ALVHLDANNN TEIFNHVLDD
VETFMDKVSM ASSAQEKSQK KKGFMKKKKK AAPVLNLPPP EEYIFFLQKV KYGFNLLAQL
EGVLTNPSSS DFVHVLFSIL AMTVPRYPAE LPPSVVSPPL TDGALQLLSV TTSNEEKQLW
GSLGDSWNIS RSRWPEDIPP YIPQFYDGWQ PPTPAPPPYQ NHSPEQFSRS NSRIFPSGQP
EYEQPVRDEP WNSQPPRSSE PPMYARAIYD FTARNSQELT VTKGDMVQVV KMSNNWWLIR
NNRGEEGNVP RNVVELTRSS SPPGDQQWNP GGPVPLDTNS RPQEVKAWLE YKGFSRITVN
TLGVLTGKLL LGMTKEEIRT VCPEEGSKVF FQLQAVKSAM ALAGEQTGMF GRRY
//
