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Database: UniProt
Entry: H2T0B9_TAKRU
LinkDB: H2T0B9_TAKRU
Original site: H2T0B9_TAKRU 
ID   H2T0B9_TAKRU            Unreviewed;      1970 AA.
AC   H2T0B9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   20-DEC-2017, entry version 37.
DE   SubName: Full=Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b {ECO:0000313|Ensembl:ENSTRUP00000018107};
GN   Name=cacna1a {ECO:0000313|Ensembl:ENSTRUP00000018107};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000018107, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000018107}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000018107}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000018107}.
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DR   Ensembl; ENSTRUT00000018181; ENSTRUP00000018107; ENSTRUG00000007330.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 5.
DR   PRINTS; PR00167; CACHANNEL.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    149    171       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    334    353       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    365    385       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    397    418       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    461    483       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    536    562       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1023   1041       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1061   1081       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1093   1111       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1155   1177       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1267   1292       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1348   1366       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1378   1398       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1442   1463       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1479   1514       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      179    199       {ECO:0000256|SAM:Coils}.
FT   COILED      558    594       {ECO:0000256|SAM:Coils}.
FT   COILED      881    901       {ECO:0000256|SAM:Coils}.
FT   COILED      967    987       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1970 AA;  224790 MW;  C559A19E7628DEB5 CRC64;
     MARFGDELPN RYGGGGGGGG GGAGGQGGPG RGGSRQGGAP GAQRMYKQSM AQRARTMALY
     NPIPVRQNCL TVNRSLFLFS EDNVVRKYAK KITEWPYPFI YTHGGCPPAM VSVSGRPLMV
     LTVFQCITME GWTEMLYYSN DVEGSTWNWM YYIPLIIIGS FFMLNLVLGV LSGEFAKERE
     RVENRSEFLK LRRQQQIERE LNGYLEWICK AEEVILAEDD GTGNFDGNCD GSRRNMKTKN
     NKTELLNPEE GEDNLGDALG KRGTLVELST LLIALILHHK RVSCKKRIHW SKSMCLSLPG
     FARSSIKSGK EGSNYSKNER RLRFLIRKIV KTQAFYWTVL CLVGLNTICV AAVHYNQPQL
     LSDFLFYAEF IFLGLFMSEM LIKMYGLGIQ PYFHSSFNCF ACLQVILGSI FEVVWATIKP
     GTSFGISVLR ALRLLRIFKV TKYWAPLRNL VVSLLNSMKS IISLLFLLFL FIVVFALLGM
     QLFGGQFNFE VGTPPTNFDT FAAAIMTVFQ ILTGEDWNMV MYNGIESQGG VNDKGMIFSI
     FFIVLTLFGN YTLLNVFLAI AVDNLANAQE LTKDEEEQEE AANQKTALQK AKEVAEVSPL
     SAANLSIAAK EQQKNHIKGN KSVWEQRTSE IRRQNLMTSR EALYNELEQD DWKVGEEGGE
     VSYPRKGRGN MKTHLDRPLV VNPQDNRNNN TNRTQPGELP LEEEYRRQDV DHYQRAGHSH
     HHHRHHHHHH HHHQRASGAD NAGTRQPAET RIQHGISCTS LTNVEGQQAP ERHSHRGHCH
     RHRNRESREA RSISPHHSDA AEGTNEPRRA RQHCRAAKEG EEGRRHRSKR TEGEGEKGTE
     GEGRRSRRHC HSSQERGRGH RSRNHMNREH HRANLSTTRP IQQYNEDLDN LRNNSKLASA
     QVHPYTLPPD HPDHVNNLLN CCDTDTHTLL HSMDSLILTS MAKPDYTAID MPPVYPYPST
     NAILQVNKNA NTDQKKSEEK KEEEDEDGDE NGPKPMPPYS SCFILSTTNP FRKCCHYILT
     LKYFEFGILS VIAMSSIALA AEDPVWPDSP RNNVLRYFDY IFTGVFTFEM LIKMVVLGLF
     LHQGSYFRDL WNILDFIVVS GALVAFAFTG SSKGKDISTI KSLRVLRVLR PLKTIKRLPK
     LKAVFDCVVN SLKNVLNILI VYMLFMFIFA VVAVQLFKGR FFFCTDESKE FERDCRGEYL
     VYERDEVKAR KREWKKYDFH YNNVAWALLT LFTVSTGEGW PQVLKHSVDS TYENQGPSPG
     YRMEMSIFYV VYFVVFPFFF VNIFVALIII TFQEQGDKMM EDYSLEKNER ACIDFVINAR
     PLTRHMPKNK LSFQYRMWQF VVSPPFEYSI MALIALNTIV LMMKFNDASQ TYSDVLKYLN
     IVFTTFFFME SILKIIAFGP LNYFRDAWNI FDFVSVLGSI TDILVTEVWV RNECGSTFAY
     TYFVSFIFLC SFLMLNLFVA VIMDNFEYLT RDSSILGPHH LDEYVRIWAE YDPAACGRIS
     YTDMYQMLRH MCPPLGLGKR CPARVAYKRL LRMDLPVADD NTVHFNSTLM ALIRTALDIK
     IAKGYSGGAD KHQMDAELRK EMMAIWPNLS QKSLDQLVTP HKAATDLTVG KIYAAMMIME
     YYRQSKSKKL QAMREEQNRT PLMFQRMEPP PEGGGTEGQA GQGLNGLPNT QPDNLNNIPP
     EGGMSESQSW VTAKAQEMFQ KTGNWSPDRP YTDDLHDNCH NPQTVEMREM GRDGYSDTEP
     YHPVDGHGRT LSMPRLSADN QPALQRRRHR PRGSNLSTIT DTSPMRRSTS SLVHGRSGRG
     VRLDDYSLER VVSEEGRHGG GRRHRDRSHR ASQRSLTRYT DADTGLGTDL STTTQSGDAP
     PKDRERDRGR TKDRRHHHHH HHHHSSMDKE RYGPDRHDYS HRHPHDRHWS RSPSEGPDGR
     GHRQGSSSVS GSPVPSTSGT STPRRGRRQL PQTPAVPRPH VTYSPAVRKP
//
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