ID H2T3E2_TAKRU Unreviewed; 2004 AA.
AC H2T3E2;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=LOC101066120 {ECO:0000313|Ensembl:ENSTRUP00000019180.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000019180.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000019180.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000019180.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 3 subfamily. {ECO:0000256|ARBA:ARBA00025789}.
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DR STRING; 31033.ENSTRUP00000019180; -.
DR Ensembl; ENSTRUT00000019258.3; ENSTRUP00000019180.3; ENSTRUG00000007719.3.
DR GeneTree; ENSGT00940000156870; -.
DR HOGENOM; CLU_001541_0_0_1; -.
DR InParanoid; H2T3E2; -.
DR OMA; ASFYEIQ; -.
DR Proteomes; UP000005226; Chromosome 9.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 15.
DR Gene3D; 2.60.40.10; Immunoglobulins; 16.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF5; PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, H; 1.
DR Pfam; PF00041; fn3; 10.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 17.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 10.
DR PROSITE; PS50853; FN3; 12.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..2004
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025329226"
FT TRANSMEM 1643..1669
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..177
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 178..265
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 352..443
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 527..611
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 612..703
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 788..872
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 873..964
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1049..1135
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1136..1223
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1224..1313
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1314..1401
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1402..1491
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1710..1967
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1885..1958
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 2004 AA; 221496 MW; 6CB0DC8F9BFC6C29 CRC64;
MKPLLRVGVP LWSLLISSSL LKICQAQCDS NECSTQTGAW TTAAMPTLTA AETATQTGTM
ASAIPTTVGT FIPGPASENG TTSLHTTMQP GAVTNLQVTH FTTSSATLNW TKPAGGQSFK
VQWTDGINNR TENTTALSHT IHSLTPGVQY NVTVSAVAAD GWTEGKGQTV SLHTKPAVVR
NLTVTNVMTS SLSLSWAEPE GNAALYTIRV AGEGENIENT TTETSFVIKE LTPGSQYNIS
VAAVAVHPSN EGERASTSTF TRPEKPGNIE LTKRGTVSLS IRWSLPRGKF QHFLVDVNET
GSGSVYKNAT TANAASITGL GPGRSYAITV TSVAGSFEET SKQYEFATSP TPPGSIMVSL
KTNSSLLLEW ATPALMEGVQ TLSYNVTYQS DGKEMQTITT SVNRTELFNL SSGTLYNITL
ITNGIQNLHS TAVHYSDFTR PNPVLNLVAI PKSISSLEVK WSYPQGAQAS YTYFVSLPQF
KTTVSTNSTE IHNLDPGTCY NITVKTVVAP QSESTEEKTH ACTMPRAVSN LTVKAVNMTA
IQLTWLRQPD YKGHYSYLVV ARQAGTKVQN DTTSYEAYTF SNLTPGALYY FEVFTVVDGV
RSEVTMISID TKPAPATNVT VTGSTTNLSV SWRAPPEQVV SYTVLVFRDN QLQVFNKSLD
NRTTNTVVTD LVPGVYYCVV VVTKSKTWET NSSEVCRATV PNPPGSIVVM SKTIKSINIS
WPLPQYMDHK QYNFTVSSVN GNFITENSWF LLDNLQSGTL YNISVATVGV CNYESTPVFA
SSYTMPRAVS NLTVKAVNMT AIQLTWLRQP DYKGHYSYLV VARQAGTKVQ NDTTAYENYT
FSNLTPGALY YFEVFTVVDG VRSEVTMISI DTKPAPATNV TVTGSTTNLS VSWRAPPEQV
VSYTVLVFRD NQLQVFNKSL DNRTTNTVVT DLVPGVYYCV VVVSKSKTWE TNSSEVCRAT
IPNPPGSIVV MSKTIKSINI SWPLPQYMDH KQYNFTVSSV NGNFITENSW FLLDNLQSGT
LYNISVATVG VCNYESTPVV ASSYTKPHPV HNLTATEVTT NTVTLTWEQL ESKPSYSYMV
QAANDSVFWS KEVFITTVTI TGLTPGSRYN FIVTSQTADG TQALQVSRSF YTQSDRVHPS
VSTISNSSLL VSWRTPLGSV GHYLVRLNSS FSQDEQLVTL KNTSKNHVFG DLSAGRLYSV
QVTVCSGPFN ASSEIASNAT FPNPPGSLHI PAKTNNSIDV KWQEAPLMTK GSFHYRVSIT
APEGGVSVPG TITNHTFTSL LSGTSYNLTV LTVGALGFES EKVQIYTVNT RPFSVNNLSL
SSVGLNQTTL VWDHPDEYKE SYRYNVTWKS SENVSSVQTR EKTYNISDLV PGSRYQFFVT
TETFDGTQAD SQSISNCTDA SPVSWLQCDS PNTPDATLLV SWASPRGQYD DFEVNVNDDK
INRSINRTCC SHNVSNLQHH TVYHLTVRTQ SCGRPSISVS LQCRTGITNP PSLQGNEKLV
QVSEKTDKKF SIQIDPRLLN DTNGPITHVG VLLTHDTPGN SADWRMYLGK TYAEWKESKA
QAYLATVMSI SDLRGAQTNY TLHVGDESKW ENYTNGPLDP GGIYHFAVLV FTDLVLENNV
VNGVASLVSS TSFSQVDLIG NSAIGIAIGA TLGFFLVFFI ILIGFIIYWR RLSSKEEVDI
QIHSMRSMAV RMEDYEVYYR KQKADSNCGF AEEFEDLKPV GTDQPKGVAL TLENKPKNRY
NNVLPYDSSR VKLSIIHGSP YDDYINANYI PGYNSRKEFI AAQGPLPSTV KDFWRMIWEK
NVQTLVMLTR CNEQGRVKCE QYWDFGTKHF ENINVTAVSD IPLEDWTIRD FDIKNVKTAE
TRSVRQFHFT AWPDHGVPET TELLINFRHL VREHMDQYSR HSPTVVHCSA GVGRTGTFIA
MDRLIFQIER ENIVDIYGIV HDLRMHRSLM VQTEDQYVFL NQCALDIIRS RTGTNVDLIY
QNTAALSIYE NIEPHKNYYR YPDA
//
