ID H2T3Z4_TAKRU Unreviewed; 847 AA.
AC H2T3Z4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Vacuolar protein sorting-associated protein 41 homolog {ECO:0000256|PIRNR:PIRNR028921};
GN Name=vps41 {ECO:0000313|Ensembl:ENSTRUP00000019382.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000019382.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000019382.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000019382.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in vesicle-mediated protein trafficking to
CC lysosomal compartments including the endocytic membrane transport
CC pathways. {ECO:0000256|PIRNR:PIRNR028921}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR028921}. Late endosome membrane
CC {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR028921}. Early endosome membrane
CC {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR028921}. Lysosome membrane
CC {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR028921}. Golgi apparatus, trans-Golgi network
CC {ECO:0000256|PIRNR:PIRNR028921}. Cytoplasmic vesicle, clathrin-coated
CC vesicle {ECO:0000256|PIRNR:PIRNR028921}.
CC -!- SIMILARITY: Belongs to the VPS41 family.
CC {ECO:0000256|ARBA:ARBA00009582, ECO:0000256|PIRNR:PIRNR028921}.
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DR RefSeq; XP_011606323.1; XM_011608021.1.
DR AlphaFoldDB; H2T3Z4; -.
DR STRING; 31033.ENSTRUP00000019383; -.
DR Ensembl; ENSTRUT00000019460.3; ENSTRUP00000019382.3; ENSTRUG00000007800.3.
DR GeneID; 101065212; -.
DR KEGG; tru:101065212; -.
DR CTD; 27072; -.
DR GeneTree; ENSGT00390000000481; -.
DR OrthoDB; 8838at2759; -.
DR Proteomes; UP000005226; Chromosome 10.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0030897; C:HOPS complex; IEA:UniProtKB-UniRule.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034058; P:endosomal vesicle fusion; IEA:UniProtKB-UniRule.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006623; P:protein targeting to vacuole; IEA:InterPro.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProtKB-UniRule.
DR CDD; cd16690; RING-H2_Vps41; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019453; VPS39/TGF_beta_rcpt-assoc_2.
DR InterPro; IPR016902; VPS41.
DR InterPro; IPR045111; Vps41/Vps8.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12616; VACUOLAR PROTEIN SORTING VPS41; 1.
DR PANTHER; PTHR12616:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG; 1.
DR Pfam; PF00637; Clathrin; 1.
DR Pfam; PF10367; Vps39_2; 1.
DR PIRSF; PIRSF028921; VPS41; 1.
DR SMART; SM00299; CLH; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50236; CHCR; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR028921};
KW Endosome {ECO:0000256|PIRNR:PIRNR028921};
KW Golgi apparatus {ECO:0000256|PIRNR:PIRNR028921};
KW Lysosome {ECO:0000256|PIRNR:PIRNR028921};
KW Protein transport {ECO:0000256|PIRNR:PIRNR028921};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transport {ECO:0000256|PIRNR:PIRNR028921}.
FT DOMAIN 712..800
FT /note="Vacuolar sorting protein 39/Transforming growth
FT factor beta receptor-associated"
FT /evidence="ECO:0000259|Pfam:PF10367"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 847 AA; 98404 MW; 891F7271A3089952 CRC64;
MAEVEEEARK QSEEFTDESE EEDSEDEPKL KYERLANGVT EILQKDAASC MTVHDKFLAL
GTHFGKVFLL DIQGNVTQKF EVSSVKINQI SLDESGEHIG VCSEDGKVQV LGLYTREGFH
EIFDCPIKVV AVHPQFTKSN YKQFVTGGKK LLLYERNWLN RWKMTVLHEG EGSITNIKWR
ANLIAWANNV RVKIYDISSK QCITNVLRDN VHLRPDMYPC SLCWKDNTTL IIGWGTSIKI
CAVKERNPTE MRDLPSRYVE IVTAFETEFF ISGLAPLADQ LVVLYFVKNS DHMDEEFRAR
PRLDIILPLH ESYEEISSDA LTVRNFRDNE CRDYRLEHSE GESLFYIISP KDIVGARERD
QDDHIDWLLE KKKYEEALMA ADISFKNIKR HDVQKIGMAY INHLVEKGDY DTAARKCQKV
LGKNMELWEN EVYRFRTIGQ LKAISQYLPR GDLRLKPAIY EMILYEFLKT DYEGFATLIS
TWPGDLYNNK VIVQAVNDHL QKDPSNSTLL TTLAELCTYD QRYDKALEIY LKLRHKDVYQ
LIHRHNLFTS IEDKIVLLMD FDKEKAVDML LDNEDKISID RVVEELADRP KLLHMYLHEL
FKRDHHKGQK YHERQIGLYA EFDRPNLLPF LRDSTHCPLE KALEVCQQRN FVEETVFLLS
RMGNSRRALQ MIMEELQDVD KAIEFAKEQD DAELWEDLIS YSIDKPPFIT GLLNNIGTHV
DPILLIHRIK EGMEIPNLRD SLVKILQDYN LQILLREGCK KILVADSLSL LQKMHKTQMR
GVRVDEENIC ESCHAAILPS DMGKPFGVVM FHCRHMFHRE CLPSSGGAFP GVQYCNICSA
KRVDPWK
//
