ID H2T4E8_TAKRU Unreviewed; 953 AA.
AC H2T4E8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=GPI ethanolamine phosphate transferase 2 {ECO:0000256|ARBA:ARBA00020830};
GN Name=PIGG {ECO:0000313|Ensembl:ENSTRUP00000019536.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000019536.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000019536.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000019536.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.
CC {ECO:0000256|ARBA:ARBA00005315}.
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DR AlphaFoldDB; H2T4E8; -.
DR STRING; 31033.ENSTRUP00000075076; -.
DR Ensembl; ENSTRUT00000019615.3; ENSTRUP00000019536.3; ENSTRUG00000007856.3.
DR eggNOG; KOG2125; Eukaryota.
DR GeneTree; ENSGT00910000144269; -.
DR TreeFam; TF300609; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000005226; Chromosome 14.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd16024; GPI_EPT_2; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037674; PIG-G_N.
DR InterPro; IPR039527; PIGG/GPI7.
DR InterPro; IPR045687; PIGG/GPI7_C.
DR PANTHER; PTHR23072:SF0; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2; 1.
DR PANTHER; PTHR23072; PHOSPHATIDYLINOSITOL GLYCAN-RELATED; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR Pfam; PF19316; PIGO_PIGG; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..28
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 501..526
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 678..695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 707..728
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 740..756
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 797..815
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 866..889
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 915..935
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 545..942
FT /note="GPI ethanolamine phosphate transferase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19316"
SQ SEQUENCE 953 AA; 106063 MW; 05B5894D015149F8 CRC64;
MKVRTSVFAT LILMSEVIGI ALFLRGFFPV PIKSSLASKN SLSDLPAEPL SGSSPNTTRL
PHPLFKRVVI MLVDALRDDF LFGPNGGTFM PYTRHVVERS SSYSFVAKAR PPTVTMPRIK
ALTTGSIPGF IDVVMNLNSP ALLEDNLIWQ AKTAEKRIIF YGDDTWVRLF PKHFMEYDGT
TSFFVSDYTE VDNNVTRHLD STLKRDDWDI LILHYLGLDH IGHISGPYSS LIQPKLMEMD
DVLKKIHGAL ISKEAEGSLP YLLVLCGDHG MSETGSHGGS SEPEVNTPLV LISPAFKRKV
GMEKPGVIEQ VDLAPTLALG LGLPISQNSV GRVIPGVFQE SSLRDQLRFL HLNGHQLNCL
LKDSMPSYEK EAGFEQYRVA EKAHGNWMKL YFEGNTSEVL SNMGKKVLKQ YLEALAALSS
ALSKQLGKYD MYSMIAGMVF VFQLLMILLL AMPEALSADA AVDLPVASAL LSLPFYLLCL
LLASVHVLVC TSATSSCYYC TLSWGLVFVV VAFSSAMFCI LISMAVRRLS LGLKYNGKSP
LKTNVSEWSL SELDVLLLAG TVGHTLSLAA SSFIEEEHQT WYFLLNTLCL AMFQDVCRKY
FREKSTSKDE EDCLLPSKDC WNSALPQPDA SSEKWLALAT PIFTLVCCRL LRSINQTGVQ
WAHLPDVGHW LNSSEHRTVL SLLTVFCLVL TYLLVQRRCS WVSKVALAFG LVGVYSYRAA
VGNVIFPWQH SSRTMSKGTV EARFVYVFVL GILFSGTKDL LRSQIITADA KLKSRGLWEI
YSGLVLLASL LFRAHNLPVL CCCLLIQTLI SQFIWKKLHY DAAQITIMHY WFGQAFFYFQ
GNSNNIATID ISVGFVGLES YVEAPAIFLT ALSTYAGPLL WTCHLVCYLS SERHRSPVSV
GHGCYCLALL RSVPAAVYIV LVTVLRYHLF IWSVFSPKLL YESMHLLLTA GRP
//
