ID   H2T8F9_TAKRU            Unreviewed;       853 AA.
AC   H2T8F9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=Heat shock 70 kDa protein 4-like {ECO:0000313|Ensembl:ENSTRUP00000020949.2};
GN   Name=LOC101062856 {ECO:0000313|Ensembl:ENSTRUP00000020949.2};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000020949.2, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000020949.2, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000020949.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000256|ARBA:ARBA00007381}.
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DR   RefSeq; XP_011609590.1; XM_011611288.1.
DR   RefSeq; XP_011609592.1; XM_011611290.1.
DR   AlphaFoldDB; H2T8F9; -.
DR   STRING; 31033.ENSTRUP00000020949; -.
DR   Ensembl; ENSTRUT00000021036.3; ENSTRUP00000020949.2; ENSTRUG00000008366.3.
DR   GeneID; 101062856; -.
DR   KEGG; tru:101062856; -.
DR   CTD; 335865; -.
DR   eggNOG; KOG0103; Eukaryota.
DR   GeneTree; ENSGT00940000156067; -.
DR   HOGENOM; CLU_005965_5_1_1; -.
DR   OrthoDB; 276440at2759; -.
DR   TreeFam; TF105043; -.
DR   Proteomes; UP000005226; Chromosome 15.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 2.
DR   Gene3D; 3.30.30.30; -; 1.
DR   Gene3D; 3.30.420.40; -; 2.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR45639:SF6; HEAT SHOCK 70 KDA PROTEIN 4; 1.
DR   PANTHER; PTHR45639; HSC70CB, ISOFORM G-RELATED; 1.
DR   Pfam; PF00012; HSP70; 2.
DR   PRINTS; PR00301; HEATSHOCK70.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 2.
DR   SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT   REGION          500..591
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          797..853
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        504..589
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        816..841
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   853 AA;  95953 MW;  012FA46CF9EB82E9 CRC64;
     MSVVGFDLGF QSCYVAVARG GGIETVANEY SDRCTPSFVS FGQRNRLIGA AAKSQVVTNC
     QNTVQGFKRF HGRAFADPYV QSAKSNLVYN LAQMSSGVTG IKVMYMEEER VFSIEQVTGM
     LLTKLKETAE SALKKPVADC VISVPSFFTD AERSSVMDAA QIAGLNCLRL MNDTTAVTLA
     YGIYKQDLPA PEEKPRIVVF VDVGHSGYQV SVCAFNKGKL KILATAFDPE LGGKDFDDIL
     VKHFCEEFSK KYKLDARSKP RALVRLYQEC EKLKKLMSAN SSDLPLGIEC FMNDIDVSSK
     LNRGQFEEMC AGLLAKVEGP LCSVMEQTKM KKEDIYAVEI VGGASRIPAI KERIAKFFGK
     ELNTTLNADE AVARGCALQC AILSPAFKVR EFSITDVVPY SISLKWNSAA DDGLNDCEVF
     PKNHAAPFSK VLTFYRKEPF TLDAYYNNLK ELPYPNSSIG QFLIQNVVPQ ESGECAKVKV
     KVRVNVHGVF SVSNASLVET VKTPEGEEPM ETDQTVKEEE KKMQVDQEDQ KHQAGDKEEK
     KSETEEMETS EHGKQEKTEN GKQEKSGDGK QEKKNDQPPQ AKKPKVKTKT VELPVQNNLH
     WQLPTDVLNM FVENEGKMIM QDKLEKERND AKNNVEEYVY EMRDKLHGIL EKFVNEADRD
     AFSLKLEDTE TWLYEEGEDQ QKQVYIDKLA ELKKMGQPVL DRYMESEIRP KAFEELGRQI
     QVYMKFIEAY KTKDEQYNHL DELEVTRVEK QVNDAMAWMN NKMNQQNSQD LTLDPVVKVQ
     EIQATAKELY SACNPVVSKP KPKVELPKDE KTENGPVNGH QGTENQSPNP DKTTSAGMEQ
     ETAETKLPEM DID
//