ID H2TB04_TAKRU Unreviewed; 456 AA.
AC H2TB04;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=ArfGAP with dual PH domains 1 {ECO:0000313|Ensembl:ENSTRUP00000021844.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000021844.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000021844.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000021844.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; H2TB04; -.
DR STRING; 31033.ENSTRUP00000051891; -.
DR Ensembl; ENSTRUT00000021933.3; ENSTRUP00000021844.2; ENSTRUG00000008701.3.
DR GeneTree; ENSGT00940000155698; -.
DR Proteomes; UP000005226; Chromosome 5.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:1902936; F:phosphatidylinositol bisphosphate binding; IEA:InterPro.
DR CDD; cd08832; ArfGap_ADAP; 1.
DR CDD; cd13252; PH1_ADAP; 1.
DR CDD; cd01251; PH2_ADAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037849; PH1_ADAP.
DR InterPro; IPR037851; PH2_ADAP.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46021:SF5; ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46021; ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 88..208
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 211..312
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 334..438
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 456 AA; 51759 MW; CF51AB9B551460E6 CRC64;
MGVSSRTSCS VMTAGGVTVT RHANAESGLL TAACGLHHAS LSGNSAVTEQ FSKVASAPRA
GVRGFRPPRR RIRAEPSATM TSDQVVNRQR VKRLVEKPGN GTCADCGAAD PEWASYTLGV
FVCQSCSGLH RNIARISKVK SILLDPWSSS EVEFMDSVGN DASKAKYERL VPAFYYRPSH
TDCTLLRDQW IRAKYEREEF TSVERQEPYS AGYREGFLWK RGRDNGQYLS RRFILSEREG
VLKYFNKHDA REPKAMMKIG SLNATFQPSK IGTPHGLQIT YLKDNSTRNI FVYHEEGKEI
VDWFNAIRAA RFHYLQVAFP VAAVSELLPK LTRNFIREGY MEKTGPKQTE GFKKRWFTLD
DRRLMYFKDL LDAYARGEVF IGSKESGYTA LPGLPPNIQS SHWQFGITIV TPDRNFLFAC
ETERDQKHWI TAFETVINRP MLPQDYAVEA FFKHKP
//
