ID H2TC37_TAKRU Unreviewed; 1050 AA.
AC H2TC37;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
GN Name=gucy2f {ECO:0000313|Ensembl:ENSTRUP00000022229.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000022229.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000022229.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000022229.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|RuleBase:RU003431};
CC -!- SUBCELLULAR LOCATION: Photoreceptor outer segment membrane
CC {ECO:0000256|ARBA:ARBA00004451}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004451}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR AlphaFoldDB; H2TC37; -.
DR STRING; 31033.ENSTRUP00000071141; -.
DR Ensembl; ENSTRUT00000022320.3; ENSTRUP00000022229.3; ENSTRUG00000008848.3.
DR GeneTree; ENSGT00940000165991; -.
DR Proteomes; UP000005226; Chromosome 8.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06371; PBP1_sensory_GC_DEF-like; 1.
DR CDD; cd14043; PK_GC-2D; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR PANTHER; PTHR11920:SF349; RETINAL GUANYLYL CYCLASE 2; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431}; Coiled coil {ECO:0000256|SAM:Coils};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Vision {ECO:0000256|ARBA:ARBA00023305}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1050
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025440748"
FT DOMAIN 492..771
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 843..973
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 780..811
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1050 AA; 117967 MW; 3453FEBF3769140E CRC64;
MILCDLQRVI LVSLCLLLSP AQAAWFRVGV VGPWGCDPLF AKALPHVAAQ LAVNRINRDP
SLSYAATFDY VVLQEPCETS RALEAFLGFH TKATGYIGPT NAGYCDAASM LSKGWNKALF
PWGCVGYELD DIRSHPTFAH SMPRPTWVLL SFVRYFRWAH IGIISSSDEI WVETATKVAD
ALRSHGLAVK LVSFMENTPH GIRRTLSKVR QMKELRVVIL CMHSVLIGGE VQKLLLETAY
DMEMIDGSLV FVPYDTLLYS LPYRNVTYPV LKSNGKLLRA YDAVLTVTID SPKMSFYESY
REAMEKREVA GTLKPQEVSP LFGTIYNSIF FMAHAVHHLR RSGKWMSGGN LARQTRNLAV
QGFSHLIKTN DSGSSLVDYV ILDTDGLSWE LKPSYRIDME GGFVHFLGRD IHFPHGFGPR
RDSSCWFTPG VICSGGVDLI IASRNESNLL FVIVLPARRR INQIRMVRGP NKILLTLDDV
TFINPSLSNK KLSLDDSRAS GMRSVSERSV VSPVSTKSPA THENSNIVIY EGDWAWLKRL
PYGTFSNINP KTSNVFELMK DMRHENINPF LGFFHDCGVF AIVTEFCSRG SLEDLLENDD
VKLDWMFKSS LLLDLIKGMK YLHHRGVSHS RLKSRNCVVD GRFVLKITDY GFNEVLDAQR
FPYTEPPVDE LLWTAPEILR MPGQPGVYGT LPGDVYSFAI IMQEVVIRGP PFCMLNLSIL
EKLCKPPPLC RPVVSPDYAP LECIQLMKQC WSEQPDKRPA FDEIFDQFKN INKGKKTNII
DSMLRMLEQY SSNLEELIRE RTEELEIEKQ KTEKLLTQML PPSVAEALKV GGIVEPEHFD
SVTIYFSDIV GFTTISANSE PIEVVELLNT LYTIFDAIIG NHDVYKVETI GDAYMVASGL
PVSNGNRHAA EIANMSLDIL SAVGTFKMRH MPDVPVRIRI GLHTGPCVAG VVGLIMPRYC
LFGDTVNVAS RMESTGLPYR IHVHQSTVKV LRDLNLGYKL ELRGKTEVKG KGYEETYWLV
GRDGFTKPLP VPPEIKSGVT DDIHENFAAF
//
