GenomeNet

Database: UniProt
Entry: H2TCJ6_TAKRU
LinkDB: H2TCJ6_TAKRU
Original site: H2TCJ6_TAKRU 
ID   H2TCJ6_TAKRU            Unreviewed;       337 AA.
AC   H2TCJ6;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   24-JAN-2024, entry version 53.
DE   RecName: Full=Urotensin-2 receptor {ECO:0000256|ARBA:ARBA00014302};
DE   AltName: Full=Urotensin II receptor {ECO:0000256|ARBA:ARBA00032764};
GN   Name=UTS2R {ECO:0000313|Ensembl:ENSTRUP00000022388.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000022388.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000022388.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000022388.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: High affinity receptor for urotensin-2 and urotensin-2B. The
CC       activity of this receptor is mediated by a G-protein that activate a
CC       phosphatidylinositol-calcium second messenger system.
CC       {ECO:0000256|ARBA:ARBA00025579}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|RuleBase:RU000688}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; H2TCJ6; -.
DR   STRING; 31033.ENSTRUP00000022388; -.
DR   Ensembl; ENSTRUT00000022481.3; ENSTRUP00000022388.3; ENSTRUG00000008902.3.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00940000157017; -.
DR   HOGENOM; CLU_009579_1_1_1; -.
DR   InParanoid; H2TCJ6; -.
DR   OMA; HRSFYRY; -.
DR   TreeFam; TF334200; -.
DR   Proteomes; UP000005226; Chromosome 1.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001604; F:urotensin II receptor activity; IEA:InterPro.
DR   GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:InterPro.
DR   CDD; cd14999; 7tmA_UII-R; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000670; Urot_II_rcpt.
DR   PANTHER; PTHR24230; G-PROTEIN COUPLED RECEPTOR; 1.
DR   PANTHER; PTHR24230:SF53; UROTENSIN II RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00647; UROTENSIN2R.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|RuleBase:RU000688};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transducer {ECO:0000256|RuleBase:RU000688};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000688};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        55..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        79..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        122..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        169..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        218..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        260..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          15..279
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
SQ   SEQUENCE   337 AA;  38156 MW;  D3F6BEBC7EA8C1F7 CRC64;
     GQTVVGHRPK LHSLGTVDHE LVITTTFGTL LSVVYAVGVS GNVYTLVVMC HSIRLATSMY
     ISIINLAVDW YFGDVGCRIL LSLDLLTMHA SIFTLTVMCT ERYLAVTKPL DTVSRSKSYR
     KALAWGVWLL SLVLTVPMMT MVTQTTQITP DGGVKRMCAP TWAPSAYKVY VTVLFGTSIM
     APGIIIGYLY IRLAHTYLES QHNSVIRKGG KRSPKQKVLI MIFTIVLVFW ACFLPFWIWQ
     LLPLYHTKPL SLASQTHTCI NYLVASLTYS NSCINPFLYT LLTKNYREYL KNRHRSFYRY
     TSSFKQRPPS LYTWGKSASS SNQFEFNSET LVMGMLK
//
DBGET integrated database retrieval system