ID H2TGF8_TAKRU Unreviewed; 886 AA.
AC H2TGF8;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 24-JAN-2024, entry version 62.
DE SubName: Full=Transportin 2 {ECO:0000313|Ensembl:ENSTRUP00000023756.3};
GN Name=TNPO2 {ECO:0000313|Ensembl:ENSTRUP00000023756.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000023756.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000023756.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000023756.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; H2TGF8; -.
DR STRING; 31033.ENSTRUP00000050893; -.
DR Ensembl; ENSTRUT00000023854.3; ENSTRUP00000023756.3; ENSTRUG00000009453.3.
DR eggNOG; KOG2023; Eukaryota.
DR GeneTree; ENSGT00940000156708; -.
DR HOGENOM; CLU_008136_0_0_1; -.
DR TreeFam; TF300825; -.
DR Proteomes; UP000005226; Chromosome 17.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF17; TRANSPORTIN-2; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 31..99
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REGION 342..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..366
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 886 AA; 99695 MW; F30421D37F7A0868 CRC64;
MEWQPDEQGL QQVLQLLKDS QSPDTATQRA VQEKLEQLNQ FPDFNNYLIF VLTSLKSEDE
PTRSLSGLIL KNNVKAHYQS FPPNVADFIK RECLNNIGDP SPLIRATIGI LITTIASKGE
LQTWPELLPQ LCNLLNSEDY NTCEGSFGAL QKICEDSSEL LDSEALNRPL NIMIPKFLQF
FKHCSPKIRS HAIACVNQFI IGRAQALMDN IDTFIESLFA LAGDEDSEVR KNVCRALVML
LEVRIDRLIP HMHSIIQYML QRTQDPDENV ALEACEFWLT LAEQPICKEA LSGHLVQLIP
ILVNGMKYSE IDIILLKGDV EEDEAIPDSE QDIKPRFHKS RTVTLQHEGG EGEEGEDIDD
DEDDDDDALS DWNLRKCSAA ALDVLANVFR DELLPHLLPL LKGLLFHHDW VIKESGILVL
GAIAEGCMQG MVPYLPELIP HLIQCLCDKK ALVRSIACWT LSRYAHWVVS QPPDAHLKPL
MTELLKRILD GNKRVQEAAC SAFATLEEEA CTELVPYLSF ILDTLVFAFG KYQHKNLLIL
YDAIGTLADS VGHHLNQPEY IQKLMPPLIA KWNELKDEDK DLFPLLECLS SVATALQSGF
LPYCEPVYQR CVTLVQKTLA QAMMYSQQPD QYEAPDKDFM IVALDLLSGL AEGLGGHVDT
LVARSNIMTL LFQCMQDTMP EVRQSSFALL GDLTKACFLH VKPCIAEFMP ILGTNLNPEF
ISVCNNATWA IGEICMQMGV EMQPYIAMVL NQLVEIINRP NTPKTLLENT AITIGRLGYV
CPQEVAGMLP QFIRPWCTSL RNIRDNEEKD SAFRGICMMI GVNPGGVVQD FIFFCDAVAS
WVNPKDDLRD MFYKVRSWLN DRAIESLEFS RLGTTCPDQR SRTLGG
//