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Database: UniProt
Entry: H2TGJ8_TAKRU
LinkDB: H2TGJ8_TAKRU
Original site: H2TGJ8_TAKRU 
ID   H2TGJ8_TAKRU            Unreviewed;       756 AA.
AC   H2TGJ8;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 37.
DE   SubName: Full=Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 {ECO:0000313|Ensembl:ENSTRUP00000023796};
GN   Name=HCN2 (1 of many) {ECO:0000313|Ensembl:ENSTRUP00000023796};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000023796};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000023796}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000023796}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000023796}.
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DR   Ensembl; ENSTRUT00000023894; ENSTRUP00000023796; ENSTRUG00000009472.
DR   GeneTree; ENSGT00900000140801; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013621; Ion_trans_N.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08412; Ion_trans_N; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM     59     83       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     89    108       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    260    278       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    290    313       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      391    497       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   756 AA;  85198 MW;  51F8A936EFE98656 CRC64;
     EARGSQASFM QRQFSSMLQP GVNKFSLRMY GSQKAVEREQ ERVKSAGNWI IHPYSDFRFY
     WDFTMLLFMV GNLIIIPVGI TFFKEETTTP WIIFNVVSDT FFLMDLVLNF RTGIIIEDNS
     DIILDPKTIK KKYLKTWFIV DFISSIPVDY IFLIVEKGID SEVYKTARAL RIVRFTKILS
     LLRLLRLSRL IRYIHQWEEI FHMTYDLASA VMRIINLIGM MLLLCHWDGC LQFLVPMLQD
     FPSDCWVSLN KMENDTWSEL YSFAVFKAMS HMLCIGYGRQ APESLSDIWL TMLSMIVGAT
     CYAVFIGHAT ALIQSLDSSR RQYQEKYKQV EQYMSFHKLP ADFRQKIHDY YEHRYQGKMF
     DEESILGELS EPLREEIVNF NCRKLVASMP LFANAEPNFV TAMLTKLRFE VFQPHDYIIR
     EGTIGKKMYF IQHGVCSVIT KGTLAMKLSD GSYFGEICLL TRGRRTASVR AETYCRLYSL
     SVDHFNEVLE EYPMMRRAFE TVAIDRLNRI GKKNSILMHK VQHDLNSGVF NNQENEMIQE
     IVKYDREMVK LVDLQRPRAM SMTPSIGGIF APPGQPHTGS AIATLQQAVA MSFCPQMASP
     LVGPGTLQSP RMVRRFQVMQ NLSSPVSMSP LQSQPPQAFG GAFGSAISSP PVQSPLTATG
     RTFQYMASSG PSGSLSQDTR ALSASQPSLP QEGTPQAASA APSPPASTHT SNSGPTGMGV
     AAAVGSGPPD SGAPKKDSIV SLPELDSARS RLSSNL
//
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