ID H2TIE3_TAKRU Unreviewed; 566 AA.
AC H2TIE3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Nectin cell adhesion molecule 4b {ECO:0000313|Ensembl:ENSTRUP00000024445.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000024445.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000024445.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000024445.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nectin family.
CC {ECO:0000256|ARBA:ARBA00007810}.
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DR AlphaFoldDB; H2TIE3; -.
DR Ensembl; ENSTRUT00000024544.3; ENSTRUP00000024445.3; ENSTRUG00000009732.3.
DR GeneTree; ENSGT00940000157535; -.
DR HOGENOM; CLU_029618_1_1_1; -.
DR InParanoid; H2TIE3; -.
DR OMA; VNRHHRH; -.
DR Proteomes; UP000005226; Chromosome 22.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR23277:SF11; NECTIN-4; 1.
DR PANTHER; PTHR23277; NECTIN-RELATED; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..566
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025678191"
FT TRANSMEM 335..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..139
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 144..228
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 237..326
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 487..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 64111 MW; C795655086F234BC CRC64;
MNRFGDTVAV CLQLLLSRLT CAQGVFVEPL EPITSQHSLA EGETRLPCHY QVEEEEKVVQ
VTWFKEHADG TKEQIITAHF MDGHTEFGHY AGRVRFERSI PMENSALLIS STEVSDEGRY
TCHISTFPNG NFERRVTLSV WILPIAALEP EVLVEGQTFR VAASCRAVGR PRPRLTWNTD
LPGQYTDRIK EDGSVSSFYS LHPLRSMNGK KLDCMVWHAG LEQPRRITNY LIVHYPPDAA
ISSATAEWFV GLKKGELVCS SGGYPKPENV TWKWYRNGGA LPDGTSVVGE KLIFGRPLRL
NDSGLYECVV KNKLGFGKTE YMMTISDDSP ISKQFLTIIG ASAGALVIFL VTVVFLVNCY
HRQKNRKLVR QLSGKMEEIN NLSRETSLRR LNSFSTDPRV QGEVDVDELG RPCVWPNGSK
NLRETEMEIE KERRRVVSYL KNSNMSLVHP FYLQLFNYFE NLNDIENDDK YSLCSVCQDS
GLLSSMGPIK VQQDDSDSEQ SNPKEEDSPQ SIVEGYEGDE DSSFYQLSEA LTNHFYYSNG
VLRPKLHPNA ILLHSRFVSI HYSYIP
//
