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Database: UniProt
Entry: H2TL59_TAKRU
LinkDB: H2TL59_TAKRU
Original site: H2TL59_TAKRU 
ID   H2TL59_TAKRU            Unreviewed;      2006 AA.
AC   H2TL59;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   22-NOV-2017, entry version 41.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=LOC446050 {ECO:0000313|Ensembl:ENSTRUP00000025414};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000025414, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000025414}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000025414}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000025414}.
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DR   Ensembl; ENSTRUT00000025517; ENSTRUP00000025414; ENSTRUG00000010095.
DR   eggNOG; ENOG410INF8; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    126    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    194    213       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    225    246       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    252    272       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    386    413       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    754    772       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    784    807       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    819    843       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    864    892       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    954    977       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1219   1237       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1258   1277       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1289   1312       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1333   1360       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1457   1480       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1539   1557       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1569   1587       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1599   1619       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1656   1684       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1760   1783       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      133    419       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      501    702       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      754    981       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      991   1212       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1217   1489       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1538   1793       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1797   1859       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED      410    451       {ECO:0000256|SAM:Coils}.
FT   COILED      489    511       {ECO:0000256|SAM:Coils}.
FT   COILED     1984   2006       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2006 AA;  227406 MW;  92B7592F18CDA165 CRC64;
     KMAQLLVPPG PDSFRPFVPE SLATIERRIA EEEARRPRAG RRSDSDDENG PKPNSDLEAG
     KSLPFIYGDI PPHLVSIPIE DIDPFYSSQK TFIVLNRGKA IFRFNATPAL YILKPFNPLR
     RVAIRVLVHS YPFMLIMFTI LTNCAFMTLS NPPEWAKNVE YTFTGIYTFE SLIKILARGF
     CVGKFSFLRD PWNWLDFSVI LMAYVTEFVD LGNVSALRTF RVLRALKTIS VIPGLKTIVG
     ALIQSVKKLS DVMILTVFCL SVFALIGLQL FMGNLRQKCV RYPISSNATN STNSTADDTI
     WTEYISDDRN YYYVPGQRDA LLCGNGSGSG LCPEGFICIK AGRNPDYGYT SFDTFSWAFL
     SLFRLMTQDF WENLYQQTLR TAGKPYMIFF VLVIFLGSFY LVNLILAVVA MAYDEQNQAT
     IEEAQQKEEE FQAMLEQLKR QQEEAQSANE IHSSIGWQVA AAAAIEGGGY IGTGCPTSES
     SSGMSKLSSK SAKERRNRRK KRKQREEEEE RGNQDKFHKS ESEDSIKRSS FRFSIDPNRL
     PYEKRCSSPN QSLLSIRGSF FSPRRNSRAS LFSFHGRARD MGSENDFADD EHSTFEESDS
     RRGSLFLPRR LERRCSAVSQ TSLGAPRIML PANGKMHCAV DCNGVVSLVG ETSVTTSPVG
     LLLPEGTTTD TELKKRRSGF HQPSMDYLDE PGARQRAMSV ASILTNTILA ELEESRQKCP
     PCWYRFANTC LIWDCCPQWL KIKEIVSMVV MDPFVDLTIT ICIILNTLFM AMEHYPMTTE
     FDNVLSVGNL VFTGIFTAEM CLKIIALDPY YYFQEGWNIF DGIIVSLSLM ELGLANVEGL
     SVLRSFRLLR VFKLAKSWPT LNMLIKIIGN SVGALGNLTL VLAIIVFIFA VVGMQLFGKS
     YKECVCKISL DCQLPRWHMH DFFHSFLIVF RVLCGEWIET MWDCMEVAGQ SMCLIVFMMV
     MVIGNLVVLN LFLALLLSSF SADNLAATDD DSEMNNLQIA VGRIQRGVAF VKTTVRHFMQ
     SICFSRGGKG SGLGEESKPL DELHSNGKGN CISNHTSVEI TKDPSGVYMT EGNGRLGGGL
     VIGVVVGGDT TSKYPVEECD YMSFIHNPSL TVQVPIAVGE SDFENLNTED FSSDSSDVEG
     SKEINNLSSS EGSTVDIRPP GDGVESVELE PEESLEPEAC FTEGCVSRFQ CCQISEEGEN
     YKSWWTLRKT CFIIVEHNWF ETFIIFMILL SSGALAFEDI YIEQRKTVKI VLEYADKVFT
     YVFILEMLLK WVAYGFVKYF TNAWCWLDFL IVDVSLVSLV ANTLGYSELT AIKSLRTLRA
     LRPLRALSRF EGMRVVVNAL GAIPSIMNVL LVCLIFWLIF SIMGVNLFAG KFYYCINTTN
     EETLPIDIVN NKSDCLKMVN ESVRWKNVKV NFDNVGLGYL ALLQVATFKG WMDIMFPAVD
     SRNVEEQPKY EENLYMYLYF VIFIIFGSFF TLNLFIGVII DNFNQQKKKL GGQDIFMTEE
     QKKYYNAMKK LGSKKPQKPI PRPTNAFQGC LFDCITKQAF DIVIMILICL NMVTMMVETD
     DQTKDMDNIL YWINVVFIVL FTGECLLKMI SLRHYYFTIG WNVFDFVVVI LSIMGMFLSK
     VIEKYFVSPT LLRVIRLARI GRILRLIKGA KGIRTLLFAL MMSLPALFNI GLLLFLVMFI
     YAIFGMSNFA YVKRESGIND MLNFETFGNS MICLFQITTS GGWDTLLSPI LNKREPDCDS
     QLEHPGNSYK GNCGNPSVGI FFFVSYIIIC FLIVVNMYIA VILENFSVAT EESAEPLSED
     DFEMFYEVWE RFDPDATQFI EYSKLSDFAD ALDPPLRMPK PNMGQLISMD LPMVSGERIH
     CLDILFAFTK RVLGEGGEMD MLRGQMEERF MASNPSKVSY EPITTTLRRK QEEMSAIIIQ
     RAFRRYMLCL AMKKASALYK EQLKEGVRDP DKDVMVISKF TENSTSDKTD MTPSTYNSVT
     KSDKDKYEKE TQEKENKRKD LKDRKK
//
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