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Database: UniProt
Entry: H2TL66_TAKRU
LinkDB: H2TL66_TAKRU
Original site: H2TL66_TAKRU 
ID   H2TL66_TAKRU            Unreviewed;      1945 AA.
AC   H2TL66;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   30-AUG-2017, entry version 39.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=LOC446050 {ECO:0000313|Ensembl:ENSTRUP00000025421};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000025421, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000025421}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000025421}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000025421}.
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DR   Ensembl; ENSTRUT00000025524; ENSTRUP00000025421; ENSTRUG00000010095.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    125    148       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    193    212       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    224    245       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    251    271       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    389    416       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    728    746       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    758    781       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    793    817       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    838    866       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    928    951       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1213   1231       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1252   1271       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1283   1306       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1327   1354       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1451   1474       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1533   1551       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1563   1581       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1593   1613       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1650   1678       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1754   1777       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      128    422       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      484    677       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      728    955       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      965   1206       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1211   1483       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1532   1787       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1791   1853       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED      413    451       {ECO:0000256|SAM:Coils}.
FT   COILED      472    494       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1945 AA;  220717 MW;  9F30535DF34A7478 CRC64;
     MAQLLVPPGP DSFRPFVPES LATIERRIAE EEARRPRAGR RSDSDDENGP KPNSDLEAGK
     SLPFIYGDIP PHLVSIPIED IDPFYSSQKT FIVLNRGKAI FRFNATPALY ILKPFNPLRR
     VAIRVLVHSM FSMLIMFTIL TNCAFMTLSN PPEWAKNVEY TFTGIYTFES LIKILARGFC
     VGKFSFLRDP WNWLDFSVIL MAYITEFVNL GNVSALRTFR VLRALKTISV IPGLKTIVGA
     LIQSVKKLSD VMILTVFCLS VFALIGLQLF MGNLRQKCVR YPISSNATNS TNSTADDTMF
     VDNFLLELNA TGNYYYVPGQ RDALLCGNGS GSGLCPEGFI CIKAGRNPDY GYTSFDTFSW
     AFLSLFRLMT QDFWENLYQQ TLRTAGKPYM IFFVLVIFLG SFYLVNLILA VVAMAYDEQN
     QATIEEAQQK EEEFQAMLEQ LKRQQEEAQS VRAFETGCPT SESSSGMSKL SSKSAKERRN
     RRKKRKQREE EEERGNQDKF HKSESEDSIK SFKSVKQTRS LLSIRGSFFS PRRNSRASLF
     SFHGRARDMG SENDFADDEH STFEESDSRR GSLFLPRRLE RRCSAVSQTS LGAPRIMLPA
     NGKMHCAVDC NGVVSLVGET SVTTSPVGLL LPESLLHASD GTTTDTELKK RRSGFHQPSM
     DYLDEPGARQ RAMSVASILT NTMEELEESR QKCPPCWYRF ANTCLIWDCC PQWLKIKEIV
     SMVVMDPFVD LTITICIILN TLFMAMEHYP MTTEFDNVLS VGNLVFTGIF TAEMCLKIIA
     LDPYYYFQEG WNIFDGIIVS LSLMELGLAN VEGLSVLRSF RLLRVFKLAK SWPTLNMLIK
     IIGNSVGALG NLTLVLAIIV FIFAVVGMQL FGKSYKECVC KISLDCQLPR WHMHDFFHSF
     LIVFRVLCGE WIETMWDCME VAGQSMCLIV FMMVMVIGNL VVLNLFLALL LSSFSADNLA
     ATDDDSEMNN LQIAVGRIQR GVAFVKTTVR HFMQSICFSR GGKGSGLGEE SKPLDELHSN
     GKGNCISNHT SVEITKDPSG VYMTEGNGRL GGGLNPSLTV QVPIAVGESD FENLNTEDFS
     SDSSDVEGSK EVRTKSYSGW AKYIEAIMDF GCRINQMINQ WRHQWTSSPL AQKLDVVPQN
     LSSSEGSTVD IRPPGDGVES VELEPEESLE PEACFTEGCV SRFQCCQISE EGENYKSWWT
     LRKTCFIIVE HNWFETFIIF MILLSSGALA FEDIYIEQRK TVKIVLEYAD KVFTYVFILE
     MLLKWVAYGF VKYFTNAWCW LDFLIVDVSL VSLVANTLGY SELTAIKSLR TLRALRPLRA
     LSRFEGMRVV VNALGAIPSI MNVLLVCLIF WLIFSIMGVN LFAGKFYYCI NTTNEETLPI
     DIVNNKSDCL KMVNESVRWK NVKVNFDNVG LGYLALLQVA TFKGWMDIMF PAVDSRNVEE
     QPKYEENLYM YLYFVIFIIF GSFFTLNLFI GVIIDNFNQQ KKKLGGQDIF MTEEQKKYYN
     AMKKLGSKKP QKPIPRPTNA FQGCLFDCIT KQAFDIVIMI LICLNMVTMM VETDDQTKDM
     DNILYWINVV FIVLFTGECL LKMISLRHYY FTIGWNVFDF VVVILSIMGM FLSKVIEKYF
     VSPTLLRVIR LARIGRILRL IKGAKGIRTL LFALMMSLPA LFNIGLLLFL VMFIYAIFGM
     SNFAYVKRES GINDMLNFET FGNSMICLFQ ITTSGGWDTL LSPILNKREP DCDSQLEHPG
     NSYKGNCGNP SVGIFFFVSY IIICFLIVVN MYIAVILENF SVATEESAEP LSEDDFEMFY
     EVWERFDPDA TQFIEYSKLS DFADALDPPL RMPKPNMGQL ISMDLPMVSG ERIHCLDILF
     AFTKRVLGEG GEMDMLRGQM EERFMASNPS KVSYEPITTT LRRKQEEMSA IIIQRAFRRY
     MLCLAMKKAS ALYKEQLKEG VRDPD
//
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