ID H2TMZ1_TAKRU Unreviewed; 1015 AA.
AC H2TMZ1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Signal peptide, CUB domain and EGF like domain containing 3 {ECO:0000313|Ensembl:ENSTRUP00000026047.3};
GN Name=scube3 {ECO:0000313|Ensembl:ENSTRUP00000026047.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000026047.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000026047.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000026047.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_011600945.1; XM_011602643.1.
DR AlphaFoldDB; H2TMZ1; -.
DR Ensembl; ENSTRUT00000026152.3; ENSTRUP00000026047.3; ENSTRUG00000010346.3.
DR GeneID; 101079580; -.
DR KEGG; tru:101079580; -.
DR CTD; 222663; -.
DR GeneTree; ENSGT00940000153185; -.
DR InParanoid; H2TMZ1; -.
DR OMA; TCALSCP; -.
DR OrthoDB; 5477406at2759; -.
DR Proteomes; UP000005226; Chromosome 3.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF2; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 4.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1015
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025455896"
FT DOMAIN 34..74
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 305..345
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 346..384
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 385..425
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 825..937
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 350..360
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1015 AA; 111948 MW; 116E11CAE1420C7A CRC64;
MHVRGLIRAT LGFVGFCLVA FVQQSASGSK PPQDVDECAE GLDNCSIDAI CQNTVKSYKC
ICKSGYKGDG KHCEDVDECV TEYNGGCVHE CINIPGNYRC TCYDGFRLAH DGHNCLDVDE
CSEGNGGCQQ ICVNMMGSYE CRCREGFLLS DNQHTCIQRP KVQMEGAKEG PTCMDKNHGC
AHICRETQKG GIACECRPGF QLTRNNKDCK LTCNYGNGGC QHICEETDHG PKCSCHMKFV
LHSDGKTCVG ERSVPSQAAP QLFPNETCAV NNGGCDSTCH DSVTGVRCSC PVGFTLQPDR
KTCKDIDECR LNNGGCDHVC RNTVGSFECS CKKGYKLLTN ERTCQDIDEC SFDRTCDHFC
VNSAGSFQCL CHKGYVLYGL AHCGDIDECS INRGGCKYGC INSLGSYECT CPPGFKLHWN
RKDCVELVKC PPGLVAPKAT LTCNKTGKKE SCSLTCASKA HYLAESDNSY SVSCGIPILR
GKSPARLNSS SSQSCIETLA PPVKQTASFK IKNAKCHLHP KLSGRTEDRG RTLGPGSAQP
CSNCLVTFVN LKCDSSKKAK GRRARNPSNK EVTRITLELE AEVKPGDTTG SCNLSCLRQR
MEKQVKTYIK ALKKSINQER FLIRVAGLEY EVAQKLPQAA PIQENCGPGW ERDGSRCVRC
SSGSYYHGEQ ERCVPCPPGT FQEKEGQLAC DLCPGSDGHG PVGARNISSC AGQCPMGYFS
SDGFKPCQPC PQGAYQPDLG RTLCFPCGGG LSTKREGASS FHDCEVKVQC SPGHYYNTTV
HRCIRCPVGT YQTEFRQNYC ISCPGNTTTD FDGATSVSQC KNRQCGGEMG EFMGYIESPN
YPGNYPANVE CIWNINPPSK RKILIVVPEI FLPSEDECGD VLVMRKNWSA TSITTYETCQ
TYERPIAFTA RSRRLWINFK SNEVNSARGF QIPYVTYDED YEQLVEDIVR DGRLYASENH
QEILKDKKLI KTLFDVLAHP HNYFKYTTRE SNEMLPRSFI RLISSKVSAF LRPYK
//