ID H2TND1_TAKRU Unreviewed; 2791 AA.
AC H2TND1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Ubiquitin protein ligase E3 component n-recognin 5 {ECO:0000313|Ensembl:ENSTRUP00000026187.3};
GN Name=ubr5 {ECO:0000313|Ensembl:ENSTRUP00000026187.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000026187.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000026187.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000026187.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSTRUT00000026294.3; ENSTRUP00000026187.3; ENSTRUG00000010399.3.
DR eggNOG; KOG0943; Eukaryota.
DR GeneTree; ENSGT00940000156357; -.
DR HOGENOM; CLU_237999_0_0_1; -.
DR TreeFam; TF314406; -.
DR Proteomes; UP000005226; Chromosome 7.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd14423; CUE_UBR5; 1.
DR CDD; cd19675; UBR-box_UBR5; 1.
DR Gene3D; 1.10.1900.10; c-terminal domain of poly(a) binding protein; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 2.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR036053; PABP-dom.
DR InterPro; IPR002004; PABP_HYD.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR047503; UBR-box_UBR5.
DR InterPro; IPR024725; UBR5_UBA.
DR InterPro; IPR003126; Znf_UBR.
DR PANTHER; PTHR46276; E3 UBIQUITIN-PROTEIN LIGASE UBR5; 1.
DR PANTHER; PTHR46276:SF1; E3 UBIQUITIN-PROTEIN LIGASE UBR5; 1.
DR Pfam; PF11547; E3_UbLigase_EDD; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00658; PABP; 1.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00517; PolyA; 1.
DR SMART; SM00396; ZnF_UBR1; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF63570; PABC (PABP) domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS51309; PABC; 1.
DR PROSITE; PS51157; ZF_UBR; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1163..1231
FT /note="UBR-type"
FT /evidence="ECO:0000259|PROSITE:PS51157"
FT DOMAIN 2368..2445
FT /note="PABC"
FT /evidence="ECO:0000259|PROSITE:PS51309"
FT DOMAIN 2507..2791
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ZN_FING 1163..1231
FT /note="UBR-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00508"
FT REGION 79..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1501..1548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1565..1728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1843..1870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1971..2011
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2323..2383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..614
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1018
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1055
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1512..1537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1608..1637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1646..1671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1679..1728
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1983..2001
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2328..2361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 2760
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 2791 AA; 306770 MW; 624BE168CBE68735 CRC64;
MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYSYNSHPHL GLLEQATLKQ CVVGPNHAGF
LLEDGRVCRI SFAVQPDRLE LSKPDGSDGS RWSSGVNGGN GGGGSGGGAG GGGAGGGSSG
GSGSGGGGGG TSGRSSTAAR DSRRQTRVIR TGRDRGSGLL GSQPQPVIPA SVIPEELITQ
AQVVLQGKSR SVIIRELQRT NLDVNLAVNN LLSRDDEDGD DGDDTASESY LPGEDLMSLL
DADIHSAHPS VIIDADAMFS EDISYFGYPS FRRSSLSRLG PSRERDSELL RERESVLRLR
ERRWLDGASF DTERGSTSRE GEANLDKKSI PVQSPVSLGE ELQWWPDKDG VKFVSIGAMF
SELVAVSSKG ELYQWKWTEP EPFRNAQNPS IHHPRVSFLG LANEKITLLS ANSIRATVAT
ETNKVATWVD ETLSSMASKL EHSAQAFPEL QGERMVSLNC CALYTCAQLE NGLYWWGVVP
FSQRKKMLEK ARAKNKKPKS SAGMSSIPNI TVGTQVCLRN NPLYHAGAVA FSVSAGIPKV
GVLLESVWNM NDSCRFQLRS PESLKTMEKT AKTQEIKTES KPELVKTEMG PPPSPASTCS
DTSSIASSAS LPYKRRRSTP APKEEEKVNE EQWPLREVVF VEDVKNVPVG KVLKVDGAYV
AVKFPGTSSS VSNQSSAAPA DSDPSSLLQD CRLLRIDELQ VVKTGGTPKV PDCFQRTPKK
LCIPEKAEIL AVNVDSKGVH AVLKTGNWVR YCIFDLATGK AEQENNFPTS NLAFLGQSER
NVAIFTAGQE SPIILRDGNG TIYPMVKDCV GGIRDPDWLD LPPINSLGMG VHSLANLPSN
STIKKKAAII IMAVEKQTLM QHVLRCDYEA CRQYLVNLEQ AFMLDQGSQA LGALLDHRCD
GNRNILHAAV SVCFPVSNKE TKEEEEAERS ERNTFAERLS AVEAIANAIS VVSSNSSGNR
TGSSSSRGLR LREMMRRSLR AAGVGRHESG PSSSDHQDPV SPPIAPPSWV PDPPPMDPDG
DIDFILAPAV GSLTTASTGT SQGPSTSTIP GPSNESPVVE SKDRKANAHL ILKLMCDSVV
LRPHLRELLS AKDARGMTPF MLAVSGRAYP AAITVLEAAQ KMAKVGDPGI TEKEDADSVF
MEMICPSGTN PDDSPLYVLC CNDTCSFTWT GAEHINQDIF ECRTCGLLES LCCCTECARV
CHKGHDCKLK RTSPTAYCDC WEKCKCKTLI AGQKAARLDL LYRLLTTTNL VTTPNSRGEH
ILLFLVQTVA RQSVEHCQYR PPRIREDRNR KATNAEDSDM PDHDLEPPRF AQLALERVLQ
DWNALKSMIM FGSEENKDPL SASSRIAHLL SEEQVYLNQQ SGTIRLDCFT HCLIVKCAPD
ITFIDTLLST LVRELQNKYT PGRREEAVNV TRRFLRSVAR VFVILSVEMA SSKKKNNFIP
QPIGKCRRVF QALLPYAVEE LCNVAESLIV PVRMGIARPT APFTLASTSI DAVQGSEELF
SVEPLPPRPS PDQSSSSSQT AASYIIRNPQ PRHSSQSQPV RGRDEEQDDI VSADVEEVEV
VEGVAGEEDH HDDQEEQGEE NPETEGQHDE HDEDGSDMEL DLLAAAETES DSESNHSNQD
NASGRRSVVT AATAGSEAGA SSVPAFFSED DSQSNDSSDS DSSSSQSDDV DQETFLLDEP
LERTTSSSHA NSAAQAPRSM QWAVRNTPSQ RASGSAPSNS STPSASSTGL IYIDPTNLRR
SSAISSSAAA AAAALEASNS SSYLTSASSL ARAYSIVIRQ ISDLMSLIPK YNHLVYSQYP
AAVKLTYHDA VNLQNYVEEK LIPTWNWMVS IMDSTEAQLR YGSALSSAGD PGHPSHPLHA
SQHSARRERI NAREEASLRT LEGRRRAATL LTARQGMMSA RGDFLNYALS LMRSHNDEHS
DVLPVLDVCS LKHVAYVFQA LIYWIKAMNQ QTTLDTPQMD RKRNREILEL GLDNEDSEHE
NDEDTNQSST LQDKDEDPVP AETGQNHPFF RRSDSMTFLG CIPPNPFDVP LPEAIPLADQ
PHLLQPNARK EDLFGRPSQG LYSSSFMANK GLAEASVDRN CLEVNMGSSL PSPSQILPTK
MSYSANLKNV MSMESGQRNT GTQSIADHEM DTSKPGPSPQ DLAAQLKSSL LAEIGLTESD
GPPLPSFRPH CSFMGMMISH DMLLGRWRLS LELFGRVFME DVGAEPGSIL TELGGFEVKE
SKFRREMEKL RNLQSRDLAL EVDRDRDQLI QQTMRQLNAH FGRRCTTTPM AVHRVKVTFK
DEPGEGSGVA RSFYTAIALA LLSNDKLPNL DCVQSVSKGM QASNLMQRLR NRDRERERRS
GGLRAGSRRD RDRDSRRQLS IDTRPFRPSS EGNPSDEPDP LPAHRQALGE RLYPRVHAMQ
PAFASKITGM LLELSPAQLL LLLASEDSLR ARVEEAMELL IAHGRENGAD SILDLGLLEA
PEKAQQQENR KRHGSTRSVV DMELDDPDDG EDNAPLFYQP GKRGFYSPRP GKNTEARLNC
FRNIGRILGL CLLQNELCPI TLNRHVIKVL LGRKVNWHDF AFFDPVMYES LRQLIRHSQA
GEADAVFAAM DLAFAIDLCK EEGAGQVELL SGGVNMPVTP LNVYEYVRKY AEHRMLVVAE
QPLHAMRKGL LDVLPKNALE DLTAEDFRLL VNGCGEVNVQ MLISFTSFND ESGENADKLL
QFKRWFWSIV EKMSMTERQD LVYFWTSSPS LPASEEGFQP MPSITIRPPD DQHLPTANTC
ISRLYVPLYS SKQILKQKLL LAIKTKNFGF V
//
