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Database: UniProt
Entry: H2TSS5_TAKRU
LinkDB: H2TSS5_TAKRU
Original site: H2TSS5_TAKRU 
ID   H2TSS5_TAKRU            Unreviewed;      1135 AA.
AC   H2TSS5; H2TSS2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   24-JAN-2024, entry version 61.
DE   SubName: Full=Sulfatase 1 {ECO:0000313|Ensembl:ENSTRUP00000027733.3};
GN   Name=sulf1 {ECO:0000313|Ensembl:ENSTRUP00000027733.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000027733.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000027733.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000027733.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000256|ARBA:ARBA00004241}.
CC       Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00004240}. Golgi apparatus,
CC       Golgi stack {ECO:0000256|ARBA:ARBA00004348}.
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC       {ECO:0000256|ARBA:ARBA00008779}.
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DR   AlphaFoldDB; H2TSS5; -.
DR   STRING; 31033.ENSTRUP00000027733; -.
DR   Ensembl; ENSTRUT00000027843.3; ENSTRUP00000027733.3; ENSTRUG00000010989.3.
DR   GeneTree; ENSGT00940000157544; -.
DR   InParanoid; H2TSS5; -.
DR   OMA; WKCVNED; -.
DR   OrthoDB; 1365192at2759; -.
DR   Proteomes; UP000005226; Chromosome 10.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell.
DR   GO; GO:0008484; F:sulfuric ester hydrolase activity; IEA:InterPro.
DR   GO; GO:0008015; P:blood circulation; IEA:Ensembl.
DR   GO; GO:0010669; P:epithelial structure maintenance; IEA:Ensembl.
DR   GO; GO:0048885; P:neuromast deposition; IEA:Ensembl.
DR   GO; GO:0048070; P:regulation of developmental pigmentation; IEA:Ensembl.
DR   GO; GO:2000290; P:regulation of myotome development; IEA:Ensembl.
DR   GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR   GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
DR   GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
DR   CDD; cd16147; G6S; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR024609; Extracellular_sulfatase_C.
DR   InterPro; IPR024607; Sulfatase_CS.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR43108:SF1; EXTRACELLULAR SULFATASE SULF-1; 1.
DR   PANTHER; PTHR43108; N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER; 1.
DR   Pfam; PF12548; DUF3740; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR   PROSITE; PS00523; SULFATASE_1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..1135
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5025562757"
FT   DOMAIN          42..372
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
FT   DOMAIN          530..670
FT                   /note="Extracellular sulfatase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12548"
FT   REGION          474..501
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          924..943
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          954..1005
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1104..1135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          635..662
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        474..499
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        971..985
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1135 AA;  129190 MW;  44F9C6601FC52AA2 CRC64;
     MLMVAWLVLL SLEWAPGSLA FITTRAQGLR GRIQRDRRNI RPNIILIMTD DQDVELGSLQ
     VMNKTRKIME DGGTTFTNAF VTTPMCCPSR SSMLTGKYVH NHNTYTNNEN CSSPSWQAQH
     EPRSFAVYLN NTGYRTGFFG KYLNEYNGSY IPPGWREWVG LIKNSRFYNY TVCRNGYKEK
     HGGEYAKDYF TDLITNDSIN FFRISKRMFP HRPVMMVISH AAPHGPEDSA PQYADHFPNA
     SQHITPSYNY APNMDKHWIM QYTGPMRPIH MEFTNFLHRK RLQTLMSVDD SVQKVYDMLE
     ETGELENTYI IYTADHGYHI GQFGLVKGKS MPYDFDIRVP FFLRGPNVES GAVNPHLVLN
     IDLAPTILHI AGLDTPPDMD GKSLLKLLEQ ERTGNRFKPN RKPKVWRDTF LVERGKMLRK
     KDDSASTQHT NSLPKYKKVK ETCQQAEFQT PCEQPGQKWH CVEEITGKWR IQKCKGSPKE
     SSRKRVRSLR PRSGYDNGER GCDCGEAAFK PSKVERRSHR QLSSGQRYRP RFVHTRPTRS
     LSVEFEGQIY DIDLQADDQS GIRRRAISKR HHNAEDPEYD LGSDDGSEEM LGDDTNAVGY
     PNSLKVTHKC FILMNDSVRC EREIYQSSRA WKDHKSYVDQ EIETLQDKIK NLREVRGHLK
     RTRPEECDCD GKSYYTRGDK NKAERTKNRK DQLHPFKETA QEADGKAQLY NEIRRRKKER
     KEKKRQRKGD DCSLPGLTCF THNNDHWQTA PFWSLGPFCA CTSSNNNTYW CLRTINETHN
     TLFCEFSTGF LEYFDLNSDP YQLTNAVYTV DRDILNTLHA QLMEMRSCQG YKQCNPRPKG
     ADAAHSPYGT DDRVKLPNLT DEEVNWQGLE DLYSINESLY ECRPDSSPSP DNWVNFQKDV
     DKMFALRRLF KKFNRTHTFD ESTLAELGSG AGGGGPEEGS GEELVDLATE ARLTTPAPSR
     TPPAPPHTAR PAPERKPEPV VNDIPERLSD KPAGPATPSL AASGGGRVLQ SNMWAQLEEM
     EGEVFSGNGL MELETHHSNL LRTHSSRQGL LEPGPGPGGE LLGLSPEEED IFQAQGYLPF
     SPQTLSPPTT QTSRSTLQAL ARAALAPPSD FEGSGALPPS LQSDTVRQMR RPPGQ
//
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