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Database: UniProt
Entry: H2TT08_TAKRU
LinkDB: H2TT08_TAKRU
Original site: H2TT08_TAKRU 
ID   H2TT08_TAKRU            Unreviewed;       511 AA.
AC   H2TT08;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 35.
DE   SubName: Full=Transmembrane phosphatase with tensin homology {ECO:0000313|Ensembl:ENSTRUP00000027816};
GN   Name=LOC101074730 {ECO:0000313|Ensembl:ENSTRUP00000027816};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000027816, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000027816}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000027816}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000027816}.
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DR   RefSeq; XP_003971378.1; XM_003971329.2.
DR   RefSeq; XP_011610011.1; XM_011611709.1.
DR   STRING; 31033.ENSTRUP00000027816; -.
DR   Ensembl; ENSTRUT00000027926; ENSTRUP00000027816; ENSTRUG00000011021.
DR   GeneID; 101074730; -.
DR   KEGG; tru:101074730; -.
DR   eggNOG; KOG2283; Eukaryota.
DR   eggNOG; COG2453; LUCA.
DR   GeneTree; ENSGT00760000119113; -.
DR   InParanoid; H2TT08; -.
DR   KO; K18079; -.
DR   OMA; YFWFNTS; -.
DR   OrthoDB; EOG091G09VG; -.
DR   TreeFam; TF354329; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:Ensembl.
DR   GO; GO:0016314; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; IEA:Ensembl.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR   GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR   GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:Ensembl.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR014020; Tensin_C2-dom.
DR   InterPro; IPR029023; Tensin_phosphatase.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   Pfam; PF00782; DSPc; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF10409; PTEN_C2; 1.
DR   SMART; SM01326; PTEN_C2; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS51182; C2_TENSIN; 1.
DR   PROSITE; PS51181; PPASE_TENSIN; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     56     80       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     92    111       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    123    142       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      192    368       Phosphatase tensin-type.
FT                                {ECO:0000259|PROSITE:PS51181}.
FT   DOMAIN      375    511       C2 tensin-type. {ECO:0000259|PROSITE:
FT                                PS51182}.
SQ   SEQUENCE   511 AA;  58061 MW;  E0878B8BBC640DAF CRC64;
     MSSVYFDPGS DSGVNGNVAK MEDAEVTIDD GKDDSVVPDT LYHNVRKKVK PVVTSFGFRV
     FGVVLILVDF VLVVVDISLY DRSREVGDAL EAVSLLISLF FLADVLLRVF VEGFQVYFSS
     RLNIVDACVV AVTLVVTMIY TFSDLSGASL IPRAVSFLRF LRIIILVRVF RLASQKKELE
     KVTRRMVSEN KRRYQKDGFD LDLTYVTDRV IAMSFPSSGK QSFYRNPIRE VARFLDTKHE
     GHYKVYNLCS EKGYDPQFFH YRVERVFVDD HNVPSLEDML KYTASVREWM SADPKNIIAI
     HCKGGKGRTG TMICTWLIDS DQFESAQDSL EYFGERRTDK SRSSKFQGVE TPSQSRYVGY
     YEIMKNSFNR QLPPPKRLGI KSIRIHSIAG VGKGDGSDLK VKIILKKQLI FQGVCAKQEN
     CTVFPDVGNN AAVISLQNGP VVEGDVKVMF ESSAGLPKGY EDVPFYFWFN TSFVENNKLF
     LSREELDNPH KPKTWDLYKE DFGVTLFFSE P
//
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