ID H2TUA3_TAKRU Unreviewed; 1789 AA.
AC H2TUA3;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Kinesin family member 1B {ECO:0000313|Ensembl:ENSTRUP00000028262.3};
GN Name=kif1b {ECO:0000313|Ensembl:ENSTRUP00000028262.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000028262.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000028262.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000028262.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR STRING; 31033.ENSTRUP00000073888; -.
DR Ensembl; ENSTRUT00000028374.3; ENSTRUP00000028262.3; ENSTRUG00000011194.3.
DR GeneTree; ENSGT00940000157445; -.
DR HOGENOM; CLU_001485_10_2_1; -.
DR Proteomes; UP000005226; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd01233; PH_KIFIA_KIFIB; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR049780; PH_KIFIA_KIFIB.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF2; KINESIN-LIKE PROTEIN KIF1A ISOFORM X1; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 5..355
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 1674..1772
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1491..1541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1593..1634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 636..678
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 97..104
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1789 AA; 201283 MW; 5F3043433AF2DD35 CRC64;
MSGASVKVAV RVRPFNSREM NMDAKCIIHM QGNSTTIANP KAPKEPAKNF SFDYSYWSHT
TTEDPNFASQ NRVYNDIGKE MLQHAFEGYN VCIFAYGQTG AGKSYTMMGK QEEGQEGIIP
MLCEDLFEKI NGETNKEGLS YSVEVSYMEI YCERVRDLLN PKNKGNLRVR EHPLMGPYVE
DLSKLAVTSY TDIADLMDAG NKARTVAATN MNETSSRSHA VFTIVFTQKK HDSETDLSTE
KVSKISLVDL AGSERADSTG AKGTRLKEGA NINKSLTTLG KVISALAEVD NSTNKSKKKK
KTDFIPYRDS VLTWLLRENL GGNSRTAMVA ALSPADVNYD ETLSTLRYAD RAKNIKCNAV
INEDPNNKLV RDLKDEVSRL KELLRAQGLG DILDTPLGSL TASPSSGSLS SQVGLQSVTS
IQERIMSTPG GEEAIERLKE SEKIIAELNE TWEEKLRKTE AIRMEREALL AEMGVAIRED
GGTLGVFSPK KTPHLVNLNE DPLMSECLLY YIKDGITRVG QADAERRQDI VLSGAHIREE
HCIFRSERNA NGDVVVLLVP CEGSETYVNG KRVEDAIQLR SGNRIIMGKN HVFRFNHPEQ
ARAEREKTPS AETPMEPVDW TFAQRELLEK QGIDMKQEME KRLTEMEILY KKEKEEADQL
LEQQRLVYES KLQELQKQVE TISLVAETPD EEELYEEEKE EEPKQLSFPW TLHEFELAQW
AFRKWRYHQF TSLRDQLWGN AVYLKEANAI SVELKKKVQF QFVLLTETLY SPLPPELASQ
EPEKERDSRP FPRTVVAVEV QDLKNGATHH WSLDKLKQRL EKMREMYDRA GEMASTNQEE
GEGPLTGNDP FYDRFHWFKL VGSSPIFHGC VNEHLADRTP SPTFSTTDSE ITEMADERQS
EMSDLIDDEA FVDDTSSDAG TEEGSDIFSD GQDPFYDRSP WFILVGRAFV YLSNLLYSVP
LVHRVAIVTE KGEVRGFLRV GVQAIAADEE APDYGSGVRQ SGTAKISFDD EYFKKNEFPS
TVMTRSGMSL EELRIVEGQG QSSEVITPSE ELNRINDIDL KLGNIADTKL SRDGLAGQLE
VGSIFTFRVT VLQASGVQPE YADIFCQFNF LHRHDEAFST EPLKNSGKGA PLGFYHVQNI
SVEVTESFIE YIKSKPIVFE VFGHYQQHPL HLHGQELISP PTQSRKYYPI PMPLSKPVPA
TKLNTITKSN LGQCVSKYDL LVWFEISELE PTGEYIPAIV DHSGGLPCHG TYLLHQGIQR
RITVTLIHEK GSELHWKDVR ELVVGRIRNK AEVDDSASDG ILSLNIISAK NIKSSHNSNR
TFYRFEAVWD SSLHNSLLLN RVTPYGEKIY MTLSAYLELD HCIQPAIITK DICMVFYSRD
AKISPPRSLR NLFVSGYSKT PDCNRVTGIY ELSLCKMSDT GSPGMQRRRR KVLDTSVAYV
RGEENLAGWR PRGDSLIVEH QWELEKMEQL HEVEKTRHLL LLREKLGDTN PAPSTKSLSE
LLSPSMSSGT LSTSTSISSQ ISSTTYESAI TPSESSGYDS TDIESLVDRE KELATKCLRL
LTHTFNSEYN QVVNSISDCK LSDISALGRD PSVTSLSSAT LTPSSTCPSL ADSRCGSIDQ
KTPENNSRAS SPSYSDYENF PMVPSVETSY LARAGKNEFL NLVPDIEEMR PGSVVSKKGF
LSFMEPRSNS WVKHFVVVRR PYVFIYNSDK DPVERGVLNL STAQVEYSED QQAMLKTPNT
FAVCTKHRGI LLQALNEKDM NDWLYAFNPL LAGTIRSKLA RRRSGLTKN
//
