ID H2TUE4_TAKRU Unreviewed; 399 AA.
AC H2TUE4;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 08-NOV-2023, entry version 64.
DE SubName: Full=Bone morphogenetic protein 2-like {ECO:0000313|Ensembl:ENSTRUP00000028303.3};
GN Name=LOC101063690 {ECO:0000313|Ensembl:ENSTRUP00000028303.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000028303.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000028303.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000028303.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; H2TUE4; -.
DR STRING; 31033.ENSTRUP00000028303; -.
DR Ensembl; ENSTRUT00000028415.3; ENSTRUP00000028303.3; ENSTRUG00000011210.3.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000165063; -.
DR HOGENOM; CLU_020515_4_2_1; -.
DR InParanoid; H2TUE4; -.
DR OMA; DRLQPCQ; -.
DR OrthoDB; 2912454at2759; -.
DR TreeFam; TF316134; -.
DR Proteomes; UP000005226; Chromosome 22.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13765; TGF_beta_ADMP; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF241; ANTI-DORSALIZING MORPHOGENETIC PROTEIN; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..399
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025660383"
FT DOMAIN 280..399
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 253..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 399 AA; 44758 MW; 584637AEBCE412B2 CRC64;
MLQGSPQILE MLMFLISLAA LMRTSGARPS LRSLENHFTI DNEPEEVRSA AIKRLLEVFG
MEDPPAIHGH KQPPQYMLDL YNTVADVDGV TKDPYLLEGN TVRSFFDKLR SEQVEYRFNL
STVASTEKIL TAELHLFKLR PQTTLAFNRH HFCQVSVYQI MDTSRGNNTH DKKLLSSRLI
PVHSVGWEVF TITQAVRSWM SDEGSNLGLH VVVRTLGGSQ IDKKLIRFAS GRHHHQSKQP
MLVLFTDDGR HSATLGSTDP HDTTATSSLP QGPMLAPSSR TARSVDYSEE EGASMPCQRL
PLYVDFEEIG WSGWIVSPRG YNAYHCKGSC PFPLGQNMRP TNHATVQSII HALKLIKSIE
TPCCVPDKLF SINLLYFDDD ENVVLKQYKD MVAGSCGCH
//