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Database: UniProt
Entry: H2TV31_TAKRU
LinkDB: H2TV31_TAKRU
Original site: H2TV31_TAKRU 
ID   H2TV31_TAKRU            Unreviewed;       896 AA.
AC   H2TV31;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   28-MAR-2018, entry version 45.
DE   SubName: Full=Potassium voltage-gated channel subfamily H member 4 {ECO:0000313|Ensembl:ENSTRUP00000028540};
GN   Name=KCNH4 (1 of many) {ECO:0000313|Ensembl:ENSTRUP00000028540};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000028540, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000028540}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000028540}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   Ensembl; ENSTRUT00000028654; ENSTRUP00000028540; ENSTRUG00000011301.
DR   GeneTree; ENSGT00900000140833; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR003950; K_chnl_volt-dep_ELK.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01465; ELKCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|SAAS:SAAS00084808};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    220    240       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    305    328       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    349    375       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    444    470       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       22     90       PAS. {ECO:0000259|PROSITE:PS50112}.
FT   DOMAIN       93    145       PAC. {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN      548    648       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
FT   COILED      857    884       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   896 AA;  100917 MW;  9AE18746BC48EC47 CRC64;
     MPVMKGLLAP QNTFLDAIAT RFDGTHSNFL LGNAQGHRGY PIVYCSDGFC ELTGFTRTEV
     MQKNCGCHFL FGADTSEHVA QQMLKALEGR EEYQAEVYFY KKNGVAFWCL LDIVPIKNEK
     GEMVLFLFSF KDISDMHGRG NHNSTEDKRH RRKNGSRFTE ARKRGRTMLY HLTSQFSRGG
     KREVNLGGSM IDKPSMPEYK VAAVQKSRFI LLHYSVSKAL WDWLILLATF YVAVTVPYNV
     SFTPYEDTVT AARSTIVSDI VVEMLFILDI ILNFRTTYVS QSGQVVYESR SICIHYVRTW
     FFVDLVAALP FDLLYAFNIT VTSLVHLLKT VRLLRLLRLL QKLDRYSQYS AMVLTLLMSM
     FALLAHWMAC IWYMIGRKEI ETNETWEIGW LHELGKRLET PYINSTLGGP TVRSSYIAAL
     YFTLSSLTSV GFGNVSANTD AEKIFSICTM LVGGIALMHA LVFGNVTAII QRMYSRRSLY
     HTRMKDLKDF IRVHRLPQQI KQRMLEYFQT TWSVNNGIDA NELLHDFPDE LRADIAMHLN
     KDILQLPVFK GASRGCLRSL SLHIKTSFCV PGEYLIRQGD ALHANYFVCS GSLEVLKDSM
     VLAILGKGDL IGSDLPGTDQ VIKTNADVKA LTYCDLQYIG LRGLREVLEL YPEYANVFAS
     DIYNNLTYNL REGSQDEGQS KLSRSPRLSL VSSPFSLLCF TASEPRLPSI VETTGDNSDD
     SFHLSPATRS RRNLLLPSLS SPVRRTSLGN LLGDELRQFN ALRRCRSPNL SRGFHSQLSS
     PQPPPKRGAD AEQKPTKLLI PTVTCFGPPD LSPRVVDGIE DNGHTFHFNG EGSGPKASTG
     GSTRESSQAN ATLLLESEEV RQGISELNHK METLNQEVSE LTKGLHHIMH ILQAHV
//
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