ID   H2TVA3_TAKRU            Unreviewed;      1051 AA.
AC   H2TVA3;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Insulin degrading enzyme {ECO:0000313|Ensembl:ENSTRUP00000028612.3};
GN   Name=ide {ECO:0000313|Ensembl:ENSTRUP00000028612.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000028612.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000028612.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000028612.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR   AlphaFoldDB; H2TVA3; -.
DR   MEROPS; M16.984; -.
DR   Ensembl; ENSTRUT00000028728.3; ENSTRUP00000028612.3; ENSTRUG00000011337.3.
DR   eggNOG; KOG0959; Eukaryota.
DR   GeneTree; ENSGT00940000155780; -.
DR   TreeFam; TF106275; -.
DR   Proteomes; UP000005226; Chromosome 4.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR032632; Peptidase_M16_M.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   Pfam; PF16187; Peptidase_M16_M; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          106..244
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          270..448
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          454..735
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
FT   DOMAIN          738..921
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   1051 AA;  121010 MW;  7D0EA0A853FDF08C CRC64;
     MLESLNLITL CSGIDSLCLF QHGGVKAEVC LSRVQSMCSC ITRTARYTRY LPTTANGPWF
     KQYFRLVSSL PVKMSDPAVK MVVDDIIRSP EDKRVYKGLE FTNGLKVMLI SDPTTDKSSA
     ALDVQIGSLS DPVNISGLAH FCEHMLFLGT KKYPKENEYS QFLSEHAGSS NAFTSGEHTN
     YYFDVSHEHL QGALDRFAQF FLCPLFDESC KDREVNAVDS EHEKNLMNDA WRLFQLEKAT
     GNPKHPFSKF GTGNKLTLET RPSNEGVDVR QELLQFHSAY YSSNLMGLCV LGRESLDELT
     SMVVQLFGEV ENKNVPIPEF PVHPFQEEQL RQFYKVVPVK DIRNLYVTFP IPDLQKYYKS
     NPGHYLGHLI GHEGPGSLLS ELKSKGWVNT LVGGQKEGAR GFMFFIINVD LTEEGLLHVE
     DIIFHMFQYI QKLRTEGPQE WVFQECKDLN KVAFRFKDKE RPRGYTSKVA SLLHYYPLKE
     VLAAEYLLED FRPDLIEMVL DKLRPEYVRV AVVSKSFEGQ TDKTEEWYGT QYKQEAISDA
     TVKKWADADL NGKFKLPMKN EFIPTNFEIY PLEKESPSVP TLIKDTAMSK VWFKQDDKFF
     LPKACLNFEF FSPFAYVDPL HCNMAYLYLE LLKDSLNEYA YAAELAGLNY DLQNTVYGMH
     LSVKGYNDKQ HIILKKIVEK MATFEIDEKR FDIIKEAYMR SLNNFRAEQP HQHAMYYLRL
     LMTEVAWTKD ELREALDDVT LPRLKAFIPQ LLSRLHIEAL LHGNITKESA LGMMQMVEDT
     LIEHAHTKPL LPSQLIRYRE VQIPDGGWYV YQQRNEVHNN CGIEIYYQTD LQATHENMLL
     ELFCQIISEP CFNTLRTKEQ LGYIVFSGPR RANGVQGLRF IIQSEKAPHY LESRVEAFLC
     TMEKAVEEMS EEAFQKHIQA LAIRRLDKPK KLSAECGKHW GEIISQQYHF DRDTIEVAYL
     KTLTKDNVMQ FYTERLAVGA LKRHKVSVHV LSREMDSCPV VGEFPAQNDV NLAPAPSLPQ
     PSLVQDMTEF KRSLPLFPLV RPHINFMAAK L
//