ID   H2TVG4_TAKRU            Unreviewed;       562 AA.
AC   H2TVG4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 69.
DE   SubName: Full=Polypyrimidine tract binding protein 1a {ECO:0000313|Ensembl:ENSTRUP00000028673.3};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000028673.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000028673.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000028673.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; H2TVG4; -.
DR   Ensembl; ENSTRUT00000028789.3; ENSTRUP00000028673.3; ENSTRUG00000011360.3.
DR   eggNOG; KOG1190; Eukaryota.
DR   GeneTree; ENSGT01050000244924; -.
DR   HOGENOM; CLU_015171_7_1_1; -.
DR   InParanoid; H2TVG4; -.
DR   OMA; EHHAMAG; -.
DR   TreeFam; TF319824; -.
DR   Proteomes; UP000005226; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
DR   GO; GO:0060729; P:intestinal epithelial structure maintenance; IEA:Ensembl.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   GO; GO:0045746; P:negative regulation of Notch signaling pathway; IEA:Ensembl.
DR   GO; GO:0060472; P:positive regulation of cortical granule exocytosis by positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   CDD; cd12693; RRM2_PTBP1_like; 1.
DR   Gene3D; 3.30.70.330; -; 4.
DR   InterPro; IPR006536; HnRNP-L/PTB.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR021790; PTBP1-like_RRM2.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   NCBIfam; TIGR01649; hnRNP-L_PTB; 1.
DR   PANTHER; PTHR15592; MATRIN 3/NUCLEAR PROTEIN 220-RELATED; 1.
DR   PANTHER; PTHR15592:SF19; POLYPYRIMIDINE TRACT-BINDING PROTEIN 1; 1.
DR   Pfam; PF13893; RRM_5; 2.
DR   Pfam; PF11835; RRM_8; 1.
DR   SMART; SM00360; RRM; 4.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 4.
DR   PROSITE; PS50102; RRM; 4.
PE   4: Predicted;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW   ProRule:PRU00176}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          60..134
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          184..260
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          368..442
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          485..560
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
SQ   SEQUENCE   562 AA;  61030 MW;  7D82F473D6E1A2FD CRC64;
     MIHKVKKNSC RPVKPVPDKG GSDELFSSCI SNGPYIMNSA NGNDTKKFKG DVRSSGVPSR
     VVHVRKLPND INEAEVIGLG LPFGKVTNLL MLKGKNQAFL ELNSEECAQT MVNYYSSVTP
     YIRNHPIYMQ YSTHKELKTD NSPNQRAQAA LQAVNALHGG GMGGMAIPTD PASIAGAAAQ
     SPVLRVIVEN LFYPVTLEVL HQIFSKFGTV LKIITFTKNN QFQALIQHVD SMTAQHAKLS
     LDGQNIYNAC CTLRISFSKL TSLNVKYNND KSRDYTRPDL PTADSQPSLD PQTMAAAFAA
     PGIISASPYG GAHAFPPAFA IQQTAGLSMP GIPTALASLG VSHGGMAAAA AAATRLGFTG
     LTPTAGHNVL LVSNLNPQSV TPHCLFILFG VYGDVMRVKI LFNKKENALV QMSDGTQAQL
     AMSHLNGQRL HGREMRVTFS KHTTVQLPRE GHEDQGLTKD YSNSPLHRFK KPGSKNYSNI
     FPPSATLHLS NIPPAVVEDD LKRLFASSGA TVKAFKFFQK DHKMALIQMG SVEEAIDCLI
     KFHNHDLGEN HHLRVSFSKS TI
//