ID   H2TWW7_TAKRU            Unreviewed;       291 AA.
AC   H2TWW7;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 3.
DT   27-MAR-2024, entry version 53.
DE   RecName: Full=Sulfotransferase {ECO:0000256|RuleBase:RU361155};
DE            EC=2.8.2.- {ECO:0000256|RuleBase:RU361155};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000029176.3, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000029176.3, ECO:0000313|Proteomes:UP000005226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA   Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu facilitates
RT   insights into distinct features of genome evolution in teleosts and
RT   mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000029176.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3'-phosphoadenylyl sulfate + thyroxine = adenosine 3',5'-
CC         bisphosphate + H(+) + thyroxine sulfate; Xref=Rhea:RHEA:26422,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58339, ChEBI:CHEBI:58343,
CC         ChEBI:CHEBI:58910, ChEBI:CHEBI:305790; EC=2.8.2.n2;
CC         Evidence={ECO:0000256|ARBA:ARBA00036007};
CC   -!- SIMILARITY: Belongs to the sulfotransferase 1 family.
CC       {ECO:0000256|ARBA:ARBA00005771, ECO:0000256|RuleBase:RU361155}.
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DR   AlphaFoldDB; H2TWW7; -.
DR   Ensembl; ENSTRUT00000029292.3; ENSTRUP00000029176.3; ENSTRUG00000021731.2.
DR   eggNOG; KOG1584; Eukaryota.
DR   GeneTree; ENSGT00940000159084; -.
DR   TreeFam; TF321745; -.
DR   Proteomes; UP000005226; Chromosome 4.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   PANTHER; PTHR11783:SF341; SULFOTRANSFERASE 6B1; 1.
DR   PANTHER; PTHR11783; SULFOTRANSFERASE SULT; 1.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361155}.
FT   DOMAIN          46..278
FT                   /note="Sulfotransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00685"
SQ   SEQUENCE   291 AA;  33408 MW;  28B29E7DD63B838E CRC64;
     MPTRIQMAQN MKEEEKQYRY NGVLYPTIMC PEENLKVLNQ FQARSDDILL VAYPKCGFNW
     MVGVMRKIIA EATGNKTETK MPPILEFFGP ENLKVIAAPS PRFLGTHLHP DNIPATFYEK
     KVKMLVVFRN PKDTLVSFFH FYNNNPVLPS GQSWDSFFSN FMKGEVSWGS YFEHALAWDQ
     RMDDPAVKVI TYEELKQDLS SGVGDISSFF SFSLTQDQVQ HITEGSTFRA MKENAGNSHA
     AIGNVIFRKG EVGDWKNHFT AEQSKEMDEV FQKHLANTKL GARLNYQKFC R
//