ID H2TYH1_TAKRU Unreviewed; 804 AA.
AC H2TYH1;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Kirre like nephrin family adhesion molecule 1 {ECO:0000313|Ensembl:ENSTRUP00000029730.3};
GN Name=kirrel1 {ECO:0000313|Ensembl:ENSTRUP00000029730.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000029730.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000029730.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000029730.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; H2TYH1; -.
DR Ensembl; ENSTRUT00000029847.3; ENSTRUP00000029730.3; ENSTRUG00000011778.3.
DR eggNOG; KOG3510; Eukaryota.
DR GeneTree; ENSGT00940000155795; -.
DR TreeFam; TF327139; -.
DR Proteomes; UP000005226; Chromosome 8.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR11640:SF158; KIN OF IRRE LIKE (DROSOPHILA)-RELATED; 1.
DR PANTHER; PTHR11640; NEPHRIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 480..506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..103
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 108..206
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 210..287
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 296..376
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 380..473
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 573..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 759..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..791
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 804 AA; 86678 MW; 95A8D076122404DD CRC64;
QDTYFFNLSL FSQEPADQSV VRGQRVILSC VVFNYTGIVQ WTKDGLALGI GEDLQAWPRY
RVLRVQELGQ YNLEILSAEL SDDSLYECQA PDAALRSRRA KLTVLIPPDD PVIDGGPEVL
LNAGESYNLS CVSRGAKPPS VIEWLKDGLP VEGANSITEV LPDRKRVTTR SFLPIQPVDT
DTGRNYSCTA TNLAVPTGKS TTVTLNVHHP PIVTLSIEPR SVLEGDRVTF TCQAHANPPI
MGYRWAKGGV VLQGARESVF TTKADHSFFT EPVSCLVFNA VGKTNVSILV DVHFGPILLV
EPQPTTVDVD SDVTLNCKWA GNPPLTLTWF KKGSNMVLSN SNQLYLKSVS QADAGQYVCK
AIVPRIGVGE TEVALTVNGP PIISSDPVQY AVRGERGEVK CYIASTPPPD NIVWAWSENV
QERYTVKSKP STEGGGVLST LTINNVMESD FLSTYNCTAW NSFGPGTMII TLEAMDEVPV
GIIAAGTVGS TIILFIFLLV LVLIFYRQRK GSRRGVTLGK PDIKVETINK ETHSLEEDSG
SVSTASRMVK AMYSPFKDEI ELKTDLRSDT LDTRQEYDLK DPTNGYYNVR ASTHDEGRPA
SGSTMHYSDY RSPAGTPGGA ASISSSTGGS GATASGGAPV PPGPLTSPGR PQACYDPRPP
SRLSHISYAQ FNTFTRGGQS QQPPANPAPV AADFPGDCSL MDSTSQLAYD NYGYPSHYQT
YRMGFAPSSL APLEAGPSYE MYGVGSGVGP GLASHGVGVG PAAPAPPRSE TGLGKYGSST
RFSYTSQHSD YSHSRHTQRM QTHV
//
