ID H2TYL7_TAKRU Unreviewed; 661 AA.
AC H2TYL7;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Receptor interacting serine/threonine kinase 1 {ECO:0000313|Ensembl:ENSTRUP00000029776.2};
GN Name=ripk1 {ECO:0000313|Ensembl:ENSTRUP00000029776.2};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000029776.2, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000029776.2, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000029776.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003975345.1; XM_003975296.2.
DR RefSeq; XP_011614421.1; XM_011616119.1.
DR AlphaFoldDB; H2TYL7; -.
DR STRING; 31033.ENSTRUP00000029776; -.
DR Ensembl; ENSTRUT00000029893.3; ENSTRUP00000029776.2; ENSTRUG00000011793.3.
DR GeneID; 101073092; -.
DR KEGG; tru:101073092; -.
DR CTD; 567460; -.
DR eggNOG; KOG0192; Eukaryota.
DR GeneTree; ENSGT00940000159347; -.
DR InParanoid; H2TYL7; -.
DR OMA; DIIEHCP; -.
DR OrthoDB; 3997405at2759; -.
DR TreeFam; TF106506; -.
DR Proteomes; UP000005226; Chromosome 22.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0070887; P:cellular response to chemical stimulus; IEA:UniProt.
DR GO; GO:0008152; P:metabolic process; IEA:UniProt.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:UniProt.
DR GO; GO:0031349; P:positive regulation of defense response; IEA:UniProt.
DR GO; GO:0032103; P:positive regulation of response to external stimulus; IEA:UniProt.
DR GO; GO:0010033; P:response to organic substance; IEA:UniProt.
DR GO; GO:0006950; P:response to stress; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR025735; RHIM_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR23257:SF983; RECEPTOR INTERACTING SERINE_THREONINE KINASE 1; 1.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF12721; RHIM; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 16..287
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 574..660
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 411..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 661 AA; 73715 MW; 88E3CD68886490BF CRC64;
MAAAPQLSLH MRSTDLIRKE PLDYGGFGDV YLCLHVTLGQ VVMKTIYTGP LHSKEKKKLL
IDEGSIMASL NHERVVKLLG VILEDRDCSL VMELIPRGNL LVMLQTVSVP LSVKGRVTLE
ILEAMVYLSE NDIIHKDIKP ENILVDQDFH IKIADLGLAV SQAWSKLTKE ESRRKSRQTT
GERGAGTLSY MAPEHLESIH AASMEKSDVY SFAIVLWVIL AGVEPYANAR SEDQICQCVR
KGDRPAEDLI PKDTPGKLIH LMKWSWQQDP RCRPTFKEAY DFLFPFYMET LAPCVEEDLL
KLRMMYEGPE YLVEKMKSLS LSCSLGDCPA PLVSSDSVSV PVEASIEDLH DIQSSQRYIQ
SDARAASVPQ ALEEKLNQEL QYHQGGNYNS ATQADAAKGY LHSSTNPFLP NLPDLTTSGQ
DRPYTSSVQS FTKAAPVHPT SQEDHPSADP SQSMNSTVPS KPHLSSSVTM PLLPQLNQEH
PHSLYSRQQS WPTFPATDTA TREYSLGSLL APSKSRLQDP GSLFIQNASG IQIGSNNKMS
IKSCPSWSLP PSSSDSFPFY VKEGVQKYGD HAVTEEHLDL LKENIGAKWK QIARRLGLTD
TEIETIEHDF HRDGLTEMVH QMLERWKMKE GSIGYTIGKL LRALDGNINV ELIKKILNTC
G
//
