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Database: UniProt
Entry: H2TZK9_TAKRU
LinkDB: H2TZK9_TAKRU
Original site: H2TZK9_TAKRU 
ID   H2TZK9_TAKRU            Unreviewed;      1827 AA.
AC   H2TZK9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 40.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000030118, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000030118}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000030118}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000030118}.
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DR   STRING; 31033.ENSTRUP00000030118; -.
DR   Ensembl; ENSTRUT00000030235; ENSTRUP00000030118; ENSTRUG00000011911.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   OrthoDB; EOG091G02L1; -.
DR   TreeFam; TF313555; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   GO; GO:0030317; P:flagellated sperm motility; IEA:InterPro.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IBA:GO_Central.
DR   InterPro; IPR030162; CACNA1I.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF209; PTHR10037:SF209; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23   1827       Voltage-dependent T-type calcium channel
FT                                subunit alpha. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003573862.
FT   TRANSMEM     43     63       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    278    300       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    306    331       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    656    678       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    733    756       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1058   1076       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1091   1109       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1121   1143       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1158   1184       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1219   1238       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1318   1341       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1397   1414       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1434   1453       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1517   1544       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1623   1644       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        2    342       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      534    761       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1056   1351       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1397   1654       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1350   1377       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1827 AA;  203942 MW;  21B8BEDE5B166EDD CRC64;
     STWFERVSIM VILLNCVTLG MYQPCENIDC SSDRCQILQA FDAFIYIFFA LEMVVKMVAL
     GIFGRRCYLG DTWNRLDFFI VMAGMVEYSL DLQNINLTAI RTVRVLRPLK AINRVPSLVF
     FNPCFLKLSL HQSPESGALT CVNMSSCVTL GGCMMASAHN HLRIQRDTAN IKTTGISLPR
     PYYMADEDDE RPFICSLRED NGIMSCSDIP TRREGGRVCC LDKEDVLYRQ SLGLSPEPMT
     NGSASVGGLC VNWNQYYTRC HTGHSNPHKE AINFDNIAYA WIVIFQVITL EGWVEIMYYV
     MDAHSFYNFI YFILLIIVGS FFMINLCLVV IATQFSETKQ REHQLMQEQR AQCLSSSTLA
     SEPGDCYEEL FQLVCHILRK ARRQTVILFN TLRGKPRGFR GVGRGRGGKR RERKANGREG
     RQRAAMRRHA APCPHHNKPD HTSPMALTSA SVRDGCPQCA TALSLSDGVG PVCTEKDEAD
     DGAVEETDGE GVSSSNKEKR REGAANHKGC CPRRTCKDIW YGTRVKLWEI VESKYFNRGI
     MIAILINTIS MGIEHHEQPE ELTNVLEICN IVFTSMFSLE MILKLTAFGS FNYLRNPYNV
     FDGVIVIISV CEIVGQSDGG LSVLRTFRLL RVLKLVRFMP ALRRQLVVLM KTMDNVATFC
     MLLMLFIFIF SILGMHIFGC KFSIKTETGD TVPDRKNFDS LLWAIVTVFQ ILTQEDWNVV
     LYNGMAATSP LAALYFVALM TFGNYVLFNL LVAILVEGFQ AEGDANRSNS DDDRSSSNFD
     ESEKHDSIKL SDPRICTLTP NGHLELGGCS SSRGSYSSER RSVTVDSRKS SVMSLGKSSL
     ERRSLSSSSN SLGRRSYGFG GAPLVGGSLR VRSSCSPQSY PYSAEQESLL THPSHSHHPL
     SKHHPPPPLL LSRHFARRRD RRALSLELPE LLRAGGQPPG HPPFHPDTGR KSGCGAGGSV
     TGGSGIGSGL GGGHRDCNGK TPGIHTRLMS EVFPQVNARK DRADLDEETD YSLCFRIQKM
     IEVYKPDWCE TREDWSVYLF SPQNGFRLLC QSIIAHKLFD YVVLVFIFLN CITVALERPK
     ILQGSVVRIR GWRKLLSCSS FTLLIVIFLN QERVFLTISN YIFTTIFVAE MTVKVVSMGL
     YLGEKAYLRS SWNILDGFLV FVSLIDIVVS MAGGAKILGV LRVLRLLRTL RPLRVISRAP
     GLKLVVETLI TSLKPIGNIV LICCAFFIIF GILGVQLFKG KFYYCVGFDV KNITNKSDCL
     AANYRWVHHK YNFDNLGQAL MSLFVLASKD GWVNIMYHGL DAVGIDQQPI TNNNPWMLLY
     FISFLLIVSF FVLNMFVGVV VENFHKCRQH QEVEEAKRRE EKRQRRMEKK RRKAQKLPYY
     ASYGPARLAI HTLCTSHYLD LVITFIICIN VITMSLEHYS QPRSLETALK YCNYVFTSTF
     VIEASLKLVA FGFRRFFKDR WNQLDLAIVL LSVMGITLEE IESNASLPIN PTIIRIMRVL
     RIARVLKLLK MATGMRALLD TVVQALPQVG NLGLLFMLLF FIYAALGVEL FGELVCNADY
     PCEGMSRHAT FENFGMAFLT LFQVSTGDNW NGIMKDTLRE CPPGGSGSDY SCHAGLQFIS
     PLYFVSFVLT AQFVLINVVV AVLMKHLDDS NKEAQEDAEM DAEIEMELAQ GGLCCMMGGI
     GAIAGATGSA VSGAGAGAAG AVGGPGATSD EGGGGGAHEG LAQRRCRLFS PALESQWLDS
     VSLLIKDSLE GDMIDNLSGS VFHHYSSPPV CKDCRSHPQE QIKLAEVEQA SLMSEQLSDK
     SSSLALPDDL SLDEHSNYQL LVRDSQV
//
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