ID H2U282_TAKRU Unreviewed; 1909 AA.
AC H2U282;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Neuron navigator 1 {ECO:0000313|Ensembl:ENSTRUP00000031043.3};
GN Name=NAV1 {ECO:0000313|Ensembl:ENSTRUP00000031043.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000031043.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000031043.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000031043.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the Nav/unc-53 family.
CC {ECO:0000256|ARBA:ARBA00006255}.
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DR Ensembl; ENSTRUT00000031161.3; ENSTRUP00000031043.3; ENSTRUG00000012261.3.
DR GeneTree; ENSGT00940000156637; -.
DR Proteomes; UP000005226; Chromosome 3.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0022008; P:neurogenesis; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR039041; Nav/unc-53.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12784:SF3; NEURON NAVIGATOR 1; 1.
DR PANTHER; PTHR12784; STEERIN; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226}.
FT DOMAIN 1574..1721
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 918..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..1040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1272..1320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1373..1403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1843..1876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1141..1203
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 14..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..410
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 677..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..787
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..811
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..1020
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1293..1311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1376..1403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1909 AA; 205534 MW; 02F68EB40AE0F544 CRC64;
MTAKPRELDL RSAAVSCQET SQAMASRKLS GKTSALPQGS SRSSASELRV YQPTSGSIPI
PVPNPSGLRK QRSLSNLCVL TDAEKKLHLY QSPRWNDDTS RPGTGANKQG QNKTGHSGTG
KPTLSRTLSK SEQSLFQGKP KTFCSSSPSS NISKPSRIPG PGKPRGPYAE VKPISKASEA
GQIADTETTD LLTTAKFSGA GNSEANVKKV GEKGRSAAHL AEVRKEKKGT EGDEDKSFLK
VDPELVVTVL GDLEQLLFSQ MLDPESQRKR TVQNVLDLRQ NLEETMTSLR GVQLSHSLTD
GTVCYDSDEA AAFSISSLSN RSSPLSWRQG QASPRLQAGE APSTGNAQSD VPLRINHASR
IHLIEALGDS DPSLLKGKYL SNCDLVGKSP NEEEGDDEDE DDDVDIDDLG NGWDESSSIS
SGLSDGSDNL SSEEFNTSPT LNSLPTTPIG SRRNSAIVMR TDAEKRSLVH GGLSWDSDDT
KPSRKSQGSG IYDTGSLKSE SAEKWKKTRT HGEGLEGGKG ELRKPQSLGQ GNVLKKGRNP
PVGVTSPITH TSQSGLKVAG TVKTDGKPMD KSRLAVKASG LQRSSSDAGK DHKNGIGAGE
QRKPPSGLVR PSTGGNFGFK KPNPATSNGT SNVGMPTVIN TGGSAIPCGS ATVGKTPKTS
GIPIKPGAGG GVGGRKTSLD TDQSGFLSPN ARTSLQYRSL PRPAKTSALT LTRPSSARPM
STTMDAGPAP VKPSSTTPQG SRLKEPASGL GYGTGSSKGA GRGIPSPGPV NQTDREKEKE
RAKAKAVVSD SECGSGSVKA SPAQTPSENG GKLQGLRPPS SGKCVEMPSP NMNRLPGMRS
LAKPPSMVQL DKLNSNSLEV GLHDSLPPKI PPYSKLQDLA SSVGNSAAPY LTTSPAPLLS
VNSLAGYSGS VGGSGLGPRQ VSSLGVEGSR GNTSPLFHPR LTGMHRSMES LPLQMSLARE
PHDADRDDLT RGYTTIESQS KDRQADRNTS NSWSSGAKSS LSVIESSQRD RNTLPKKGLS
FSGASQVEEE VKEKGERRHS HTILNMTDSL TLPLHSPTSL PRTSKTCMVP SPVGGPPRMT
RSNSIPTQDA SLELYGASPL GSTLSLAERP RSMGMVRSGS FRDKDSDEVH GSVLSLASNA
SSSHSSQIRK LRRELESSQE KVSSLTMQLT ANDTELVELR ETIEALRTRN EEAQAVIHGA
LNTPETMKDL RIQRQNSCES ISSLNSLTSM SSLGSMKDQD AKKKKKKSWL RSSFNKAFSI
KKGSKTYSDI EEIATPDSSA PSSPKMPHEV EEGGENQSSS GLSTSSVIAE STEEVEQEET
AVSELRTELW LKERELTDIR LEALGSAHQL EHLRDAMNNM QSIVENLKAE NDHLKTGNNL
PASGPSSSTS QPSGLSSLLG PSLRQPMSMS LTKSFSLSLN DCKDPDTSSV DTLSVSSQPD
ELCARVVVRT ADQTEDAKQQ EFYLGSVPVS ARTDWASLDT LIAKTFKDYL TQVDPTASLG
LSCDSLHMYQ LSQGGQRVIG GAEPQFSPHR CFCAGSARIF VTLKGIREKC VDSLVFETMI
PKPMMLHYIS LLLKHKRLVL SGPSGTGKTH LAHRLARYLL ERSRADTEVD HEPYVLSRSS
AVTFNLHHQS QKELQLYLSD LANHIDRESG GEVPLVVIID DISDAGAVTE LVNAALTCKY
HKCPYVIGTT NQPVKMTSNH GLHLSFRMLT FSNNVEPANG FLLRYLHRKA VEAHQEKEQD
SAHRQALLCL LDWVPQLWYH LHTFLEKYST SDFLIGPCFF LSCPVSVAEF RPWFIDLWNH
SIIPYLQEGA KDGIKVHGQK AVWEDPVEWV RGTLPWPNAQ QDQSRLFHLP PPSVGPQSEE
KKPPKDTPPP STLESDPLMA MLLKLQESAN YIESPEREGC LDPTLQATF
//
