ID H2U371_TAKRU Unreviewed; 689 AA.
AC H2U371;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Interleukin-1 receptor accessory protein-like 1 {ECO:0000313|Ensembl:ENSTRUP00000031382.3};
GN Name=LOC101068376 {ECO:0000313|Ensembl:ENSTRUP00000031382.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000031382.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000031382.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000031382.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000256|ARBA:ARBA00009752}.
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DR AlphaFoldDB; H2U371; -.
DR STRING; 31033.ENSTRUP00000061219; -.
DR Ensembl; ENSTRUT00000031504.3; ENSTRUP00000031382.3; ENSTRUG00000012390.3.
DR GeneTree; ENSGT01090000260076; -.
DR HOGENOM; CLU_025552_0_1_1; -.
DR Proteomes; UP000005226; Chromosome 8.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11890:SF22; INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 1; 1.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..689
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025401009"
FT TRANSMEM 344..368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..127
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 155..225
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 235..340
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 393..549
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 651..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 689 AA; 78823 MW; AC12CD9BB55A6D7A CRC64;
SAHQNHHLLM LLMVNIPHGA LEGCTDWSVD YLKYKVLLGE PVRIKCALFY GYIRANYTHA
QSAGLSLMWY KSAGHGEFEE PISFDGMRMS KEEDAIWFRP AELDDAGYYS CVLRNSTYCM
KVSMSLTVAE NDTDLCYNSK MRFFEKAELS KSKVITCQGI EDYIQPGAEP EIVWYKECKP
KQWRQTIERR RDTLSIKEVR EDDIGNYTCE LLFGNFVVRR TTELSVTAPL TDKPPKILSP
SESQMSIIEL AIGDPVNLTC SAAFGYSGDV SPLIYWMKGD KFIEDLDEER VQETEIKEHL
GEQEVSISLT IDALEESDLG NYSCYVENGN GRRQANIQLA KKELMYTVEL AGGLGAILLL
LICLVTLYKC YRIELMLFYR NHFGSEDIDG DNKDYDAYLS YTKVDPDQWS QETREEEHFA
LEILPDVLEK HYGYKLFIPD RDLIPTGTYI EDVARCVDQS KRLIIVMTPS YVVRRGWSIF
ELETRLRNML VTGEIKVILI ECAELRGIMN YQEVEALKHT IKMLTVIKWR GPPSNKLNSK
FWKRLLYEMP FKRMEPLSIS HEQVLDVSEQ GPFGELQTVS AISMAAATST AMATAQPDLR
STFHNSCHTQ MRQKHYYRSY DYDLPPGGTL PPLSTLGSQH TYCNIPMTLI NGQRPQSKSP
RQQSLDEAHG NNAMLPLLPR ETSISSVIW
//
