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Database: UniProt
Entry: H2U6M3_TAKRU
LinkDB: H2U6M3_TAKRU
Original site: H2U6M3_TAKRU 
ID   H2U6M3_TAKRU            Unreviewed;      2169 AA.
AC   H2U6M3;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 34.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=LOC101070235 {ECO:0000313|Ensembl:ENSTRUP00000032589};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000032589, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000032589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000032589}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000032589}.
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DR   Ensembl; ENSTRUT00000032714; ENSTRUP00000032589; ENSTRUG00000012870.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005452; LVDCC_a1dsu.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF139; PTHR10037:SF139; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    112    129       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    149    168       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    180    199       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    261    284       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    340    361       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    373    395       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    538    556       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    576    598       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    668    687       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    740    767       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    886    904       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    916    935       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1002   1032       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1086   1107       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1127   1154       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1206   1226       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1238   1258       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1356   1374       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1448   1471       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1605   1639       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   2169 AA;  246187 MW;  5F957939893FB6D8 CRC64;
     EANYASSTRV APPGDDPAPA APEAPPSSTP APAPAPARTP APPPAPPTLP AQASTTIPVG
     ALAQKKRQQY AKSKKQGSNA NNRPPRALFC LNLNNPIRRA CISLVEWKPF DIFILIAIFA
     NCMALAVYVP FPEDDSNSIN HDLETVEYAF LIIFTIETFL KIVAYGLVMH QNAYVRNGWN
     MLDFVIVVIG LFSVVLEFLT KEEKGNGESS PPSMHGHGGK PGGFDVKALR AFRVLRPLRL
     VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHAT CYIPGSDSIA
     EEEPAPCAIS GHGRQCPING SECREGWQGP NGGITNFDNF LFAMLTVFQC ITMEGWTDVL
     YWVNDAVGWE TPWIYFVSLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG DFQKLREKQQ
     LEEDLKGYLD WITQAEDIDP DNEDEADEES KRNRVTLADL TEKKKGRFGW FSQSSDTHAS
     VPASETESVN TENQNGEDEK TTCCGPLCQK ISKSKFSRRW RRWNRFCRRK CRLAVKSVPF
     YWLVIILVFL NTLTISSEHY NQPLWLTEVQ DVANKVLLAL FTCEMLMKMY SLGLEAYFVS
     LFNRFDCFVV CGGITETILV ELEIMSPLGI SVFRCVRLLR IFKVTRHWQS LSNLVASLLN
     SMKSIASLLL LLFLFIIIFS LLGMQVFGGK FNFDETQTKR STFDNFPQAL LTVFQILTGE
     DWNAVMYDGI MAYGGPSSSG MIVCFYFIIL FICGNYILLN VFLAIAVDNL ADAESLNKDE
     DKKRCRCSDS CVNTVIDSSL SITETKRKMR KMRRCFLPEP QEDDEDNDDT AGEEEDPEVP
     SGPRPVISDL VKKEKITPIP EGSAFFIFST TNPVRVFCHR LINHHIFTNL ILVFIMLSSV
     SLAAEDPIRN FSARNIVLGY ADYVFTSMFT FEIILKMTTY GAFLHKGAFC RNYFNLLDLL
     VVGVSLVSFG IQSSAISVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA IRTIGNIMIV
     TTLLQFMFAC IGVQLFKGKF YRCTDEAKSS PEECKGTYIL YKDGDVNQPT IHKRVWHNSD
     FNFDNVLMAM MALFTVSTFE GWPALLYKAI DSNRENLGPI YNYRVEISIF FIIYIIIIAF
     FMMNIFVGFV IVTFQEQGEK EYKNCELDKN QRQCVEYALK ARPLRRYIPK NPYQYKFWYV
     VNSTGFEYIM FVLIMLNTLC LAVQHYGQSA LFNYVMDILN MVFTTVFTVE MVLKLIAFKP
     RLFVEKKDRM LGYFGDAWNV FDALVVIGSI VDIVLSEIDV KPTETPQVDE MGNTEDSARI
     SITFFRLFRV MRLVKLLSRG EGIRTLLWTF IKSFQALPYV ALLIAMLFFI YAVIGMQMFG
     KVAMVDGTHI NRNNNFQTFP QAVLLLFRCA TGEAWQEIML ACMSGKLCDP ESDYNPGEEM
     TCGSGFAIVY FITFYMLCAF LIINLFVAVI MDNFDYLTRD WSILGPHHLD EFKRIWSEYD
     PEAKGRIKHL DVVTLLRRIQ PPLGFGKLCP HRVACKRLVA MNMPLNSDGT VMFNATLFAL
     VRTALKIKTE GNLEQANEEL RAVIKKIWKR TSMKLLDQVV PPAGDDEVTV GKFYATFLIQ
     DYFRKFKKRK EEGLVGAHPS QNSTAMALQA GLRTLHDIGP EIRRAISCDL QDDELVDFIP
     EEDEEIYRRN GGLFANHLMN GGHRRSNGHQ TNATQRPLQV QPPPHYAHME QPVGRLSRAN
     AMSHHNQHHH HHHHHHHHHR RHHNSYGKSP KSTNINLNNA NVSSLPNGGH HRYYEHAPPN
     GYPGLRNAYY NKPRTPQAQR RRYYETYVRS HGADGHHPTI RREEEFDDDR LSGEYYSGEE
     FYEDDSMLSG DRYYSSCSSM YQTSDTEYET PKGYHHPDAY YDDDEQPLYH DSRRSPKRRL
     LPATPQGNRR PSFNFECLRR QSSQDELPHP RTALPLHLMQ HQVMAVAGLD SSRAHRLSPT
     RSTRSWATPP ATPASNDQSP YYTPLIRVEH LHRENGGGSQ VSVRKSSWYT DDPDFPLRAY
     SPVHLQVPPE YHSQFHQKRG SATSLVEAVL ISEGLGRYAK DPNFVAATKH EIADACEMTI
     DEMESAASHL LNGGMTPGVN GVNVFPILTP RDFDLQETAA SYSDEEPETE PRAPYEEDLA
     DEMICITTL
//
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