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Database: UniProt
Entry: H2U6M7_TAKRU
LinkDB: H2U6M7_TAKRU
Original site: H2U6M7_TAKRU 
ID   H2U6M7_TAKRU            Unreviewed;      2032 AA.
AC   H2U6M7;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 34.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=LOC101070235 {ECO:0000313|Ensembl:ENSTRUP00000032593};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000032593, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000032593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000032593}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000032593}.
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DR   Ensembl; ENSTRUT00000032718; ENSTRUP00000032593; ENSTRUG00000012870.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005452; LVDCC_a1dsu.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF139; PTHR10037:SF139; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     59     76       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     96    115       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    127    146       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    204    225       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    289    310       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    322    344       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    462    480       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    500    522       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    592    611       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    664    691       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    805    823       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    835    854       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    921    951       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1005   1026       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1046   1073       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1125   1145       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1157   1175       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1263   1281       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1355   1378       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1512   1546       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   2032 AA;  230785 MW;  9237A25D3A6CE7BD CRC64;
     STTIPVGALA QKKRQQYAKS KKQGSNANNR PPRALFCLNL NNPIRRACIS LVEWKPFDIF
     ILIAIFANCM ALAVYVPFPE DDSNSINHDL ETVEYAFLII FTIETFLKIV AYGLVMHQNA
     YVRNGWNMLD FVIVVIGLFS VVLEFLTKEE KGNGESSPPS MHGHGGKPGG FDVKALRAFR
     VLRPLRLVSG VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF IGKMHATCYN
     DDLSIDSIAE EEPAPCAISG HGRQCPINGS ECREGWQGPN GGITNFDNFL FAMLTVFQCI
     TMEGWTDVLY WMNDAMGFEL PWVYFVSLVI FGSFFVLNLV LGVLSGEFSK EREKAKARGD
     FQKLREKQQL EEDLKGYLDW ITQAEDIDPD NEDEADEESK RNPSVPASET ESVNTENQNG
     EDEKTTCCGP LCQKISKSKF SRRWRRWNRF CRRKCRLAVK SVPFYWLVII LVFLNTLTIS
     SEHYNQPLWL TEVQDVANKV LLALFTCEML MKMYSLGLEA YFVSLFNRFD CFVVCGGITE
     TILVELEIMS PLGISVFRCV RLLRIFKVTR HWQSLSNLVA SLLNSMKSIA SLLLLLFLFI
     IIFSLLGMQV FGGKFNFDET QTKRSTFDNF PQALLTVFQI LTGEDWNAVM YDGIMAYGGP
     SSSGMIVCFY FIILFICGNY ILLNVFLAIA VDNLADAESL NKDEDKKERC RCSDSCVNTV
     IDSSLSITET KRKMRKPEPQ EDDEDNDDTA GEEEDPEVPS GPRPVISDLV KKEKITPIPE
     GSAFFIFSTT NPVRVFCHRL INHHIFTNLI LVFIMLSSVS LAAEDPIRNF SARNIVLGYA
     DYVFTSMFTF EIILKMTTYG AFLHKGAFCR NYFNLLDLLV VGVSLVSFGI QSSAISVVKI
     LRVLRVLRPL RAINRAKGLK HVVQCVFVAI RTIGNIMIVT TLLQFMFACI GVQLFKGKFY
     RCTDEAKSSP EECKGTYILY KDGDVNQPTI HKRVWHNSDF NFDNVLMAMM ALFTVSTFEG
     WPALLYKAID SNRENLGPIY NYRVEISIFF IIYIIIIAFF MMNIFVGFVI VTFQEQGEKE
     YKNCELDKNQ RQCVEYALKA RPLRRYIPKN PYQYKFWYVV NSTGFEYIMF VLIMLNTLCL
     AVQHYGQSAL FNYVMDILNM VFTTVFTVEM VLKLIAFKPR GYFGDAWNVF DALVVIGSIV
     DIVLSEIDVS LHLDCSPRQN TEDSARISIT FFRLFRVMRL VKLLSRGEGI RTLLWTFIKS
     FQALPYVALL IAMLFFIYAV IGMQMFGKVA MVDGTHINRN NNFQTFPQAV LLLFRCATGE
     AWQEIMLACM SGKLCDPESD YNPGEEMTCG SGFAIVYFIT FYMLCAFLII NLFVAVIMDN
     FDYLTRDWSI LGPHHLDEFK RIWSEYDPEA KGRIKHLDVV TLLRRIQPPL GFGKLCPHRV
     ACKRLVAMNM PLNSDGTVMF NATLFALVRT ALKIKTEGNL EQANEELRAV IKKIWKRTSM
     KLLDQVVPPA GDDEVTVGKF YATFLIQDYF RKFKKRKEEG LVGAHPSQNS TAMALQAGLR
     TLHDIGPEIR RAISCDLQDD ELVDFIPEED EEIYRRNGGL FANHLMNGGH RRSNGHQTNA
     TQRPLQVQPP PHYAHMEQPH HHRRHHNSYG KSPKSTNINL NNANVSSLPN GGHHRYYFDS
     SKKSHLEMHG PIQLSPPNRG GAWTLTPLAS SLVRSHGADG HHPTIRREEE FDDDRLSGEY
     YSGEEFYEDD SMLSGDRMFS DAYYDDDEQP LYHDSRRSPK RRLLPATPQG NRRPSFNFEC
     LRRQSSQDEL PHPRTALPLH LMQHQVMAVA GLDSSRAHRL SPTRSTRSWA TPPATPASND
     QSPYYTPLIR VEHLHRENGG GSQVSVRKSS WYTDDPDFPL RAYSPVHLQV PPEYHSQFHQ
     KRGSATSLVE AVLISEGLGR YAKDPNFVAA TKHEIADACE MTIDEMESAA SHLLNGGMTP
     GVNGVNVFPI LTPRDFDLQE TAASYSDEEP ETEPRAPYEE DLADEMICIT TL
//
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