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Database: UniProt
Entry: H2U6M9_TAKRU
LinkDB: H2U6M9_TAKRU
Original site: H2U6M9_TAKRU 
ID   H2U6M9_TAKRU            Unreviewed;      2067 AA.
AC   H2U6M9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 35.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=LOC101070235 {ECO:0000313|Ensembl:ENSTRUP00000032595};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000032595, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000032595}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000032595}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000032595}.
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DR   Ensembl; ENSTRUT00000032720; ENSTRUP00000032595; ENSTRUG00000012870.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005452; LVDCC_a1dsu.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF139; PTHR10037:SF139; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     55     72       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     92    111       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    123    142       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    204    227       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    283    304       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    316    338       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    456    474       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    494    516       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    586    605       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    658    685       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    791    809       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    821    840       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    907    937       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    991   1012       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1032   1059       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1111   1131       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1143   1163       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1253   1271       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1345   1368       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1502   1536       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   2067 AA;  235429 MW;  39DD7F956C31703E CRC64;
     PVGALAQKKR QQYAKSKKQG SNANNRPPRA LFCLNLNNPI RRACISLVEW KPFDIFILIA
     IFANCMALAV YVPFPEDDSN SINHDLETVE YAFLIIFTIE TFLKIVAYGL VMHQNAYVRN
     GWNMLDFVIV VIGLFSVVLE FLTKEEKGNG ESSPPSMHGH GGKPGGFDVK ALRAFRVLRP
     LRLVSGVPSL QVVLNSIIKA MVPLLHIALL VLFVIIIYAI IGLELFIGKM HATCYIPGSD
     SIAEEEPAPC AISGHGRQCP INGSECREGW QGPNGGITNF DNFLFAMLTV FQCITMEGWT
     DVLYWMNDAM GFELPWVYFV SLVIFGSFFV LNLVLGVLSG EFSKEREKAK ARGDFQKLRE
     KQQLEEDLKG YLDWITQAED IDPDNEDEAD EESKRNPSVP ASETESVNTE NQNGEDEKTT
     CCGPLCQKIS KSKFSRRWRR WNRFCRRKCR LAVKSVPFYW LVIILVFLNT LTISSEHYNQ
     PLWLTEVQDV ANKVLLALFT CEMLMKMYSL GLEAYFVSLF NRFDCFVVCG GITETILVEL
     EIMSPLGISV FRCVRLLRIF KVTRHWQSLS NLVASLLNSM KSIASLLLLL FLFIIIFSLL
     GMQVFGGKFN FDETQTKRST FDNFPQALLT VFQILTGEDW NAVMYDGIMA YGGPSSSGMI
     VCFYFIILFI CGNYILLNVF LAIAVDNLAD AESLNKDEDK KRCRCSDSCV NTVIDSSLSI
     TETKRKEDDE DNDDTAGEEE DPEVPSGPRP VISDLVKKEK ITPIPEGSAF FIFSTTNPVR
     VFCHRLINHH IFTNLILVFI MLSSVSLAAE DPIRNFSARN IILGYFDYAF TAIFTVEIVL
     KMTTYGAFLH KGAFCRNYFN LLDLLVVGVS LVSFGIQSSA ISVVKILRVL RVLRPLRAIN
     RAKGLKHVVQ CVFVAIRTIG NIMIVTTLLQ FMFACIGVQL FKGKFYRCTD EAKSSPEECK
     GTYILYKDGD VNQPTIHKRV WHNSDFNFDN VLMAMMALFT VSTFEGWPAL LYKAIDSNRE
     NLGPIYNYRV EISIFFIIYI IIIAFFMMNI FVGFVIVTFQ EQGEKEYKNC ELDKNQRQCV
     EYALKARPLR RYIPKNPYQY KFWYVVNSTG FEYIMFVLIM LNTLCLAVQH YGQSALFNYV
     MDILNMVFTT VFTVEMVLKL IAFKPRGYFG DAWNVFDALV VIGSIVDIVL SEIDVRRFLC
     VPQPTETPQN TEDSARISIT FFRLFRVMRL VKLLSRGEGI RTLLWTFIKS FQALPYVALL
     IAMLFFIYAV IGMQMFGKVA MVDGTHINRN NNFQTFPQAV LLLFRCATGE AWQEIMLACM
     SGKLCDPESD YNPGEEMTCG SGFAIVYFIT FYMLCAFLII NLFVAVIMDN FDYLTRDWSI
     LGPHHLDEFK RIWSEYDPEA KGRIKHLDVV TLLRRIQPPL GFGKLCPHRV ACKRLVAMNM
     PLNSDGTVMF NATLFALVRT ALKIKTEGNL EQANEELRAV IKKIWKRTSM KLLDQVVPPA
     GDDEVTVGKF YATFLIQDYF RKFKKRKEEG LVGAHPSQNS TAMALQAGLR TLHDIGPEIR
     RAISCDLQDD ELVDFIPEED EEIYRRNGGL FANHLMNGGH RRSNGHQTNA TQRPLQVQPP
     PHYAHMEQPV GRLSRANAMS HHNQHHHHHH HHHHHHRRHH NSYGKSPKST NINLNNANVS
     SLPNGGHHRY YEHAPPNGYP GLRNAYYNKP RTPQAQSCIK KKRRYYETYV RSHGADGHHP
     TIRREEEFDD DRLSGEYYSG EEFYEDDSML SGDRYYSSYQ TSDTEYETPK GYHHPDAYYD
     DDEQPLYHDS RRSPKRRLLP ATPQGNRRPS FNFECLRRQS SQDELPHPRT ALPLHLMQHQ
     VMAVAGLDSS RAHRLSPTRS TRSWATPPAT PASNDQSPYY TPLIRVEHLH RENGGGSQVS
     VRKSSWYTDD PDFPLRAYSP VHLQVPPEYH SQFHQKRGSA TSLVEAVLIS EGLGRYAKDP
     NFVAATKHEI ADACEMTIDE MESAASHLLN GGMTPGVNGV NVFPILTPRD FDLQETAASY
     SDEEPETEPR APYEEDLADE MICITTL
//
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