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Database: UniProt
Entry: H2U824_TAKRU
LinkDB: H2U824_TAKRU
Original site: H2U824_TAKRU 
ID   H2U824_TAKRU            Unreviewed;       634 AA.
AC   H2U824;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 39.
DE   SubName: Full=Hyperpolarization activated cyclic nucleotide-gated potassium channel 4 {ECO:0000313|Ensembl:ENSTRUP00000033090};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000033090, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000033090}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000033090}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000033090}.
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DR   Ensembl; ENSTRUT00000033216; ENSTRUP00000033090; ENSTRUG00000013040.
DR   eggNOG; KOG0498; Eukaryota.
DR   eggNOG; ENOG410XPSE; LUCA.
DR   GeneTree; ENSGT00900000140801; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030552; F:cAMP binding; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0002027; P:regulation of heart rate; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR030173; HCN4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013621; Ion_trans_N.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR10217:SF375; PTHR10217:SF375; 2.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08412; Ion_trans_N; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637}.
FT   TRANSMEM     54     78       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     84    103       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    283    308       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      386    501       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   634 AA;  73022 MW;  F29F860C515E8A67 CRC64;
     QAGFMHRQFG AMLQPGVNKF SLRMFGSEKA VEREQERVKS AGFWIIHPYS DFRFYWDLTM
     LLLMVGNLII IPVGITFFKD EHTPPWIVFN VVSDTFFLMD LVLNFRTGIV KEDNTEIILD
     PQQIKIKYLR SWFVVDFISS IPVDYIFLIV ETRIDSDFYK TARALRIVRF TKILSLLRLL
     RLSRLIRYIH QWEEIFHMTY DLASAMVRIV NLIGMMLLLC HWDGCLQFLV PMLQDFPADC
     WVSKNKMVND TWGQQYSYAL FKAMSHMLCI GYGMYPPVGM TDVWLTILSM IVGATCYAMF
     VGHATALIQS LDSSRRQYQE KYKQVEQYMS FHKLPADMRQ RIHDYYEHRY QGKMFDEESI
     LGELNEPLRE EIINFNCRKL VASMPLFANA DPNFVTSMLT KLRFEVFQPG DYIIREGTIG
     KKMYFIQHGV VSVLTKGNKE TKLSDGSYFG EICLLTRGRR TASVRADTYC RLYSLSVDNF
     NEVLEEYPMM RRAFETVALD RLDRIGKKNS ILQHKVQHDL SSGVLNYQEN EIIQQIVQHD
     RDMAHCAHLM QNVPRVVGVS SSGVTTGHVT SSRCQSPIFT SSSSFAPSQV PHSQPSAKPP
     QYGSTNASPC LTPVAPSPTI QSPVAGRTFH YSDP
//
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