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Database: UniProt
Entry: H2UBH7_TAKRU
LinkDB: H2UBH7_TAKRU
Original site: H2UBH7_TAKRU 
ID   H2UBH7_TAKRU            Unreviewed;       987 AA.
AC   H2UBH7;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 36.
DE   SubName: Full=Transient receptor potential cation channel, subfamily C, member 5a {ECO:0000313|Ensembl:ENSTRUP00000034295};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000034295, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000034295}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000034295}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00933551}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000034295}.
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DR   STRING; 31033.ENSTRUP00000034295; -.
DR   Ensembl; ENSTRUT00000034421; ENSTRUP00000034295; ENSTRUG00000013453.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   InParanoid; H2UBH7; -.
DR   OrthoDB; EOG091G029I; -.
DR   TreeFam; TF313147; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015279; F:store-operated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0006828; P:manganese ion transport; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005461; TRPC5_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF24; PTHR10117:SF24; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01646; TRPCHANNEL5.
DR   SMART; SM00248; ANK; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023,
KW   ECO:0000256|SAAS:SAAS00933366}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|SAAS:SAAS00931870};
KW   Ion transport {ECO:0000256|SAAS:SAAS00929079};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00931009};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00927442}.
FT   TRANSMEM    331    351       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    363    385       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    397    417       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    437    456       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    476    497       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    517    542       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    599    621       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       62     93       ANK_REP_REGION. {ECO:0000259|PROSITE:
FT                                PS50297}.
FT   REPEAT       69     93       ANK. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00023}.
FT   COILED      227    254       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   987 AA;  112557 MW;  D6CD09F083716CAA CRC64;
     MTQLYYKKAI YSPYRDRIPL QIVRAEVELS AEERAYLTAV EKGDYAGVKH ALREAEVYYN
     IDVNCLDPLG RSALLIAIEN ENLEIMELLL DHGIHTGDAL LYAIRKEVVG AVELLLSHRR
     PSGEKQVPSL MMDSQFSEFT PDITPIMLAA HTNNYEIIKL LVQRKVTIPR PHQIRCDCVE
     CVSSSEVDSL RHSRSRLNIY KALASPSLIA LSSEDPILTA FRLGWELKEL SKVENEFRQE
     YEELSQQCKR FAKDLLDQAR SSRELETILN HRDDQSEELD PRQCHNLAKL KLAIKYHQKE
     FVAQPNCQQL LATLWYDGFP GWRRRHWAVK LVTCFIIGLL FPVFSLIYLL APKSALGNFI
     KKPFIKFICH TASYLTFLFL LLLASQHIAR TNLHMQGPPP TVVEWMILPW VLGFIWAEIK
     EMWDGGFTEY IHDWWNLMDF AMNSLYLATI SLKIVAYVKY NSSRPREEWE MWHPTLIAEA
     LFAIANIFSS LRLISLFTAN SHLGPLQISL GRMLLDILKF LFIYCLVLLA FANGLNQLYF
     YYETKASEEH NNCKGIRCER QNNAFSTLFE TLQSLFWSIF GLLNLYVTNV KARHEFTEFI
     GATMFGTYNV ISLVVLLNML IAMMNNSYQL IADHADIEWK FARTKLWMSY FDEGGTLPPP
     FNIVPSPKSV WYLLMWLHNK LCRRGPLGDD THKCENLREF TERHADSLIQ NQHYQEVIRN
     LVKRYVAAMI RSAKTDEGLT EENFKELKQD ISSFRYEVLD LLGNRRPPRR HYSSSSETAR
     EDGAMAMEDE SESGDSCGGG VQKTKGVTFM TPLEDESKPS PKLGVSALVR SISGMTQAEK
     HLSTPGGKTD SFKRLSYLFS RSKRKAPPVP LPLQSPSSYT ISDGLLRPLG SHSHSDFRLS
     DVTRSETHLN EVGRSGDVAI PSYSPLRTNG RDTLLTLPLP PPCPCQSLHC ASNMSESSSR
     LLDSSEDVFQ GGGDSCEVIE DSVTTQL
//
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