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Database: UniProt
Entry: H2UBT4_TAKRU
LinkDB: H2UBT4_TAKRU
Original site: H2UBT4_TAKRU 
ID   H2UBT4_TAKRU            Unreviewed;       850 AA.
AC   H2UBT4;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   28-MAR-2018, entry version 23.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=atp6v0a2 {ECO:0000313|Ensembl:ENSTRUP00000034402};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000034402, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000034402}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000034402}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   STRING; 31033.ENSTRUP00000034402; -.
DR   Ensembl; ENSTRUT00000034528; ENSTRUP00000034402; ENSTRUG00000013490.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   OMA; TIPSFMN; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    409    433       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    454    472       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    548    566       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    578    601       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    644    667       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    778    803       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   850 AA;  97999 MW;  87082CA2161CD4F2 CRC64;
     MGSLFRGEEM CLAQLFLQSG SAYDCISELG ELGLVEFRDL NPTVNTFQRK YVSEIKKCEE
     MERILGYLMK EVKKADISLP EGDVNPIAPL PKHILSIMEQ LQRLEVELGE VTRNKEKLQR
     NLLELTEYMH MLRITRSFVQ RSAEREHPQL HYEEFPFLDK DTMMDYSSMQ RLGAKLGFVS
     GIIQRVKIEA FERMLWRVCK GYTILTHAEV EEYLENPDTG EPTKSVVFLI SYWGDQIGQK
     VKKICDCYHC HLYPYPSSNE ERNDVLEGLK TRIQDLHTVL HRTEDYLRQV LIKASESIYT
     WIIQVKKMKA IYYILNLCSF DVTNKCLIAE VWCPVNDIPK LRRALEEGSR KSGATVPSFV
     NRIPTNNTPP TLIRTNKFTS GFQNIVDAYG VGSYREVNPA PFTIITFPFL FAVMFGDLGH
     GLIMALFASW MVLYENNRKL KNTRNEIWNM FFEGRYIILM MGLFSIYTGL IYNDCFSKSL
     NIFGSGWSVN AMFKENVWKM EDIYGNRYLT LDPNVTGVFN GPYPFGIDPI WNLAFNRLTF
     LNSYKMKMSV IVGIIHMSFG VILSTYNYMH FRKRHHLFLV FLPELLFLLC LFGYLVFMIM
     YKWLVFSAKD SRHAPSVLIH FINMFLMQGR GMQPLYPGQN GLQIFLVVIA VLSVPVLFLG
     KPLYLYWLHN DATYFSGSCQ GYERVRHDSD EELFLLSAHN MEEGSSHSDL SSSGDHEPEN
     FNFADELLHQ AIHGIEYCLG CISNTASYLR LWALSLAHAQ LSEVLWSMVM RVGLRMDISL
     GILFLVPVFG LFAVLTVSIL LVMEGLSAFL HALRLHWVEF QNKFYSGNGV KFYPFSFSLL
     PSSLESDGVL
//
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