ID H2UC25_TAKRU Unreviewed; 253 AA.
AC H2UC25;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 3.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Glial cell line-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00015922, ECO:0000256|PIRNR:PIRNR016238};
GN Name=gdnf {ECO:0000313|Ensembl:ENSTRUP00000034493.3};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000034493.3, ECO:0000313|Proteomes:UP000005226};
RN [1] {ECO:0000313|Ensembl:ENSTRUP00000034493.3, ECO:0000313|Proteomes:UP000005226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21551351;
RA Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A., Hosoya S.,
RA Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT "Integration of the genetic map and genome assembly of fugu facilitates
RT insights into distinct features of genome evolution in teleosts and
RT mammals.";
RL Genome Biol. Evol. 3:424-442(2011).
RN [2] {ECO:0000313|Ensembl:ENSTRUP00000034493.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Neurotrophic factor that enhances survival and morphological
CC differentiation of dopaminergic neurons and increases their high-
CC affinity dopamine uptake. {ECO:0000256|PIRNR:PIRNR016238}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000256|PIRNR:PIRNR016238}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|PIRNR:PIRNR016238}.
CC -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC {ECO:0000256|ARBA:ARBA00009832, ECO:0000256|PIRNR:PIRNR016238}.
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DR RefSeq; XP_003965550.1; XM_003965501.2.
DR RefSeq; XP_011603210.1; XM_011604908.1.
DR AlphaFoldDB; H2UC25; -.
DR STRING; 31033.ENSTRUP00000034493; -.
DR Ensembl; ENSTRUT00000034619.3; ENSTRUP00000034493.3; ENSTRUG00000013519.3.
DR GeneID; 101068002; -.
DR KEGG; tru:101068002; -.
DR CTD; 79379; -.
DR GeneTree; ENSGT00950000182993; -.
DR InParanoid; H2UC25; -.
DR OMA; TYHILRK; -.
DR OrthoDB; 5362928at2759; -.
DR Proteomes; UP000005226; Chromosome 6.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR016649; GDNF.
DR InterPro; IPR043401; GDNF_fam.
DR InterPro; IPR001839; TGF-b_C.
DR PANTHER; PTHR12173; GDNF SUBFAMILY OF TGF-BETA FAMILY; 1.
DR PANTHER; PTHR12173:SF1; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PIRSF; PIRSF016238; GDNF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR016238-1};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|PIRNR:PIRNR016238};
KW Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW Secreted {ECO:0000256|PIRNR:PIRNR016238}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..253
FT /note="Glial cell line-derived neurotrophic factor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025518895"
FT DOMAIN 143..253
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 28..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..46
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..153
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 160..221
FT /evidence="ECO:0000256|PIRSR:PIRSR016238-1"
FT DISULFID 187..250
FT /evidence="ECO:0000256|PIRSR:PIRSR016238-1"
FT DISULFID 191..252
FT /evidence="ECO:0000256|PIRSR:PIRSR016238-1"
FT DISULFID 220
FT /note="Interchain"
FT /evidence="ECO:0000256|PIRSR:PIRSR016238-1"
SQ SEQUENCE 253 AA; 28351 MW; C302E5BF04ABE773 CRC64;
MKLWDVLATC LLLLSSAVAR PLYQNTQPAK RTYFPGSSSD SASLSSEEEE QTFRREKHSL
QELSMEDQYD NTGPYPEQFD DVMDFIEATI GRLRRSSEPG GGPRGQREQR QRGATNAGGE
SKGHGDKRRG RGRGGGRGGK GSRGERGRER ERLSVQTRGC LLKEVHLNVT DLGLGYQTKE
ELIFRYCSGP CAEAETNYDK ILNNLTHNKK LDKDTPSRTC CRPIAFDDDL SFLDDNVVYH
TLKKHSARKC ACV
//
