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Database: UniProt
Entry: H2UCI9_TAKRU
LinkDB: H2UCI9_TAKRU
Original site: H2UCI9_TAKRU 
ID   H2UCI9_TAKRU            Unreviewed;      1651 AA.
AC   H2UCI9;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 38.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=cacna1s {ECO:0000313|Ensembl:ENSTRUP00000034658};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000034658, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000034658}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000034658}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000034658}.
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DR   Ensembl; ENSTRUT00000034784; ENSTRUP00000034658; ENSTRUG00000013571.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005450; VDCC_L_a1ssu.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF190; PTHR10037:SF190; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01634; LVDCCALPHA1S.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     56     75       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     95    116       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    128    146       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    197    219       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    312    334       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    457    473       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    493    515       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    522    547       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    582    604       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    658    684       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    824    842       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    854    876       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    940    973       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1023   1044       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1065   1091       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1134   1154       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1175   1193       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1205   1222       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1290   1309       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1377   1401       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1417   1452       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   1651 AA;  189104 MW;  206E2566E7CA9F7E CRC64;
     AKPVIMNEEE LKRKQKEKLK KLQATGGNPR PTRSLFFFTL KNPFRKACIN IVEWKAFEII
     ILLTIFANCV ALAVFLPMPE EDSNNTNASL ESLEYIFLVI FTLECFLKIV AYGFVFHEGA
     YLRNCWNILD FVIVFMGLFT FALDTINKIA GVPLEKGGGF DMKALRAFRV LRPLRLVSGV
     PSLQVVMNSI LKAMLPLLHI ALLVFLLVTI YAIMGLELFK CKMHKTCYYT GTNIYSTAEG
     ELPAPCAQAG NGRRCTINGS ECRPGWEGPN NGITHFDNIG FAMLTVYQCI TMEGWTKVLY
     WVNDAIGNEW PWLYFVPLIL LGSFFVLNLV LGVLSGEFTK EREKARSRGE FQKLRERQQL
     DEDLHGYMEW ITHAEVLDAD REGKGRRHGP AETRTQTVFT AWKAKAGSST TSGPSERSWS
     RGLLSWFCFP VFFSRLARRW NRFFRMKCLV YVKTKSFYWL VMFLVFLNTL TIATEHHHQP
     EWLTSLQDVA SRVLLVLFIV EMFIKMYALG LRAYFMSLFN RFDFFVVLCG ILEMIMFSAG
     AVTPLGFSVL RCIRLLRILK VTKYWTSLSN LVASLLNSVR SIASLLLLLF LFIVIFSLLG
     MQVFGGKFNF SDHRPRRSNF DNFPQALISV FQILTGEEWT NIMYNGIMAY GGPVIPGILV
     SIYFIVLFVC GNYILLNVFL AIAVDNLAEA ESLTSAQKEK AEEKMRRKLL RSKMPEKTDE
     ERERIAKKLA EQRAKLKIDE FESNVNEVKD PFPPNDFPGN LKDTVGDDEE VEPEIPISPR
     PRPMADLQLK EEAVPLPEAS SFFIFGPQNK FRKLCYKIIN ASSFTNLILL FILLSSISLA
     AEDPIDPKSY RNQILAYADI VFTTVFTIEI VLKMTVYGAF MHKGSFCRNS FNILDLIVVG
     VSLLSMGMES SAISVVKILR VLRVLRPLRA INRAKGLKHV VQCVFVAIKT IGNIVLVTML
     LNFMFACIGV QLFKGKFYSC TDLSKVTHEE CQGFFLKHME NSLQDTVLAE RMWLNSDFNF
     DNVLYGMLAL FTVSTIEGWP ELLYRAIDSD KEDMGPVFNN RVDVSIFFIV YIILIAFFMM
     NIFVGFVIVT FQEQGEQEYK DCELDKNQRQ CVQYALKARP LRCYIPKNPY QYRVWYIVTS
     CYFEYLMFFL IMLNTLCLGM QHCNQSDHVT KLSDMLNLIF TVLFTVEMIL KLMAFKIKGY
     FGDPWNVFDF IIVIGSVVDV ILSEVDDTNP MQAIAVSKSL PTQDSENASV SITFFRLFRV
     MRLVKLLNRS EGIRNLLWTF IKSFQALPHV ALLIVMLFFI YAVIGMQIFG KVALLDGTQI
     HRNNNFQTFP QAVLMLFRCA TGEDWQEVMM ASMYGKKCDP KSDFLPGEEY TCGSNFAVIY
     FLSFYCLCAF LILNLFVAVI MDNFDYLTRD WSLLGPHHLD EFKKIWAEYD PEATGRIKHL
     DVVTLLRRIQ PPLGFGKFCP HRAACKRLVG MNMPLNSDGT VTFNATLFAL VRTALKIKTE
     GNFEKANEEL RAIIKQIWKR TSMKLLDQVI PPIGDDEVTV GKFYATFLLQ DHFRKFLKCQ
     EEYYGYRPNK KSASGPEIQA GLRAIDDELV PEMHRTISGD LQNEEEMDRA MEAGEEGIYH
     RSHSLFGHRV DEFSSDPANE HPQHVTNQRP L
//
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