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Database: UniProt
Entry: H2UCJ2_TAKRU
LinkDB: H2UCJ2_TAKRU
Original site: H2UCJ2_TAKRU 
ID   H2UCJ2_TAKRU            Unreviewed;      1641 AA.
AC   H2UCJ2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 38.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=cacna1s {ECO:0000313|Ensembl:ENSTRUP00000034661};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000034661, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000034661}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000034661}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000034661}.
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DR   Ensembl; ENSTRUT00000034787; ENSTRUP00000034661; ENSTRUG00000013571.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005450; VDCC_L_a1ssu.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF190; PTHR10037:SF190; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   PRINTS; PR01634; LVDCCALPHA1S.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     45     64       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     84    105       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    117    135       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    186    208       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    301    323       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    409    427       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    447    463       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    483    505       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    512    537       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    572    595       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    652    674       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    806    826       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    846    864       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    931    960       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1015   1036       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1056   1083       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1126   1147       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1167   1185       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1197   1215       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1274   1296       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1364   1388       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1404   1439       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   1641 AA;  188024 MW;  FAF42AD7AADC2C89 CRC64;
     KRKQKEKLKK LQATGGNPRP TRSLFFFTLK NPFRKACINI VEWKAFEIII LLTIFANCVA
     LAVFLPMPEE DSNNTNASLE SLEYIFLVIF TLECFLKIVA YGFVFHEGAY LRNCWNILDF
     VIVFMGLFTF ALDTINKIAG VPLEKGGGFD MKALRAFRVL RPLRLVSGVP SLQVVMNSIL
     KAMLPLLHIA LLVFLLVTIY AIMGLELFKC KMHKTCYYTG TNIYSTAEGE LPAPCAQAGN
     GRRCTINGSE CRPGWEGPNN GITHFDNIGF AMLTVYQCIT MEGWTKVLYW VNDAIGNEWP
     WLYFVPLILL GSFFVLNLVL GVLSGEFTKE REKARSRGEF QKLRERQQLD EDLHGYMEWI
     THAEVLDADR EGKGRRHGPA ETRTQTVFTA WKAKAGSSTT SGPSFYGSWS RGLLSWFCFP
     VFFSRLARRW NRFFRMKCLV YVKTKSFYWL VMFLVFLNTL TIATEHHHQP EWLTSLQDVA
     SRVLLVLFIV EMFIKMYALG LRAYFMSLFN RFDFFVVLCG ILEMIMFSAG AVTPLGFSVL
     RCIRLLRILK VTKYWTSLSN LVASLLNSVR SIASLLLLLF LFIVIFSLLG MQVFGGKFNF
     SDHRPRRSNF DNFPQALISV FQILTGEEWT NIMYNGIMAY GGPVIPGILV SIYFIVLFVC
     GNYILLNVFL AIAVDNLAEA ESLTSAQKEK AEEKMRRKLL RSKMPEKTDE ERERIAKKLA
     EQRAKIEGMP TTAKLKIDEF ESNVNEVKDP FPPNDFPGDD EEVEPEIPIS PRPRPMADLQ
     LKEEAVPLPE ASSFFIFGPQ NKFRKLCYKI INASSFTNLI LLFILLSSIS LAAEDPIDPK
     SYRNQILAYA DIVFTTVFTI EIVLKMTVYG AFMHKGSFCR NSFNILDLIV VGVSLLSMGM
     ESSAISVVKI LRVLRVLRPL RAINRAKGLK HVVQCVFVAI KTIGNIVLVT MLLNFMFACI
     GVQLFKGKFY SCTDLSKVTH EECQGFFLKH MENSLQDTVL AERMWLNSDF NFDNVLYGML
     ALFTVSTIEG WPELLYRAID SDKEDMGPVF NNRVDVSIFF IVYIILIAFF MMNIFVGFVI
     VTFQEQGEQE YKDCELDKNQ RQCVQYALKA RPLRCYIPKN PYQYRVWYIV TSCYFEYLMF
     FLIMLNTLCL GMQHCNQSDH VTKLSDMLNL IFTVLFTVEM ILKLMAFKIK GYFGDPWNVF
     DFIIVIGSVV DVILSEVDSA QKTPCKPSRQ DSENASVSIT FFRLFRVMRL VKLLNRSEGI
     RNLLWTFIKS FQALPHVALL IVMLFFIYAV IGMQIFGKVA LLDGTQIHRN NNFQTFPQAV
     LMLFRCATGE DWQEVMMASM YGKKCDPKSD FLPGEEYTCG SNFAVIYFLS FYCLCAFLIL
     NLFVAVIMDN FDYLTRDWSL LGPHHLDEFK KIWAEYDPEA TGRIKHLDVV TLLRRIQPPL
     GFGKFCPHRA ACKRLVGMNM PLNSDGTVTF NATLFALVRT ALKIKTEGNF EKANEELRAI
     IKQIWKRTSM KLLDQVIPPI GDDEVTVGKF YATFLLQDHF RKFLKCQEEY YGYRPNKKSA
     SGPEIQAGLR AIDDELVPEM HRTISGDLQN EEEMDRAMEA GEEGIYHRSH SLFGHRVDEF
     SSDPANEHPQ HVTNQRPLKF S
//
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