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Database: UniProt
Entry: H2UFM2_TAKRU
LinkDB: H2UFM2_TAKRU
Original site: H2UFM2_TAKRU 
ID   H2UFM2_TAKRU            Unreviewed;      2728 AA.
AC   H2UFM2;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   22-NOV-2017, entry version 36.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor, type 3 {ECO:0000313|Ensembl:ENSTRUP00000035742};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000035742, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000035742}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000035742}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000035742}.
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DR   STRING; 31033.ENSTRUP00000035742; -.
DR   Ensembl; ENSTRUT00000035870; ENSTRUP00000035742; ENSTRUG00000013976.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; H2UFM2; -.
DR   OMA; VVVFYND; -.
DR   OrthoDB; EOG091G00T2; -.
DR   TreeFam; TF312815; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd06174; MFS; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt-bd.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2260   2282       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2294   2311       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2332   2356       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2376   2403       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2424   2446       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2551   2574       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      114    174       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      175    225       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      233    289       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      296    371       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      377    433       MIR. {ECO:0000259|PROSITE:PS50919}.
SQ   SEQUENCE   2728 AA;  310835 MW;  CD7CE4E75200F95A CRC64;
     MSDSASSFLH IGDIVSLYAE GSVNGFISTL GLVDDRCVVE PAAGDLENPP KKFRDCLFKV
     CPMSRYSAQK QFWKAKQAKH EKDKIADVVL LQKLQHASNL EQKQNETENK KVHGDVVKYG
     TVMQLLHMKS NKYLTVNKRL PALLEKNAMR VTLDGTGNEG SWLFIQPFWK LRANGDNVVV
     GDKVILNPVN AGQPLHASNY ELTDHPGCKE VNSVNCNTSW KINLFMSFSD HREEVLKGGD
     VVRLFHAEQE KFLTCDEYKS KIHVFLRTTL RQSATSATSS NALWEVEVVH HDPCRGGAGH
     WNSLYRFKHL ATGNYLAAEE NPGYKGDSAE PPSVLDSSRS NKRSHGESIK YKLVAVAHGN
     DIASLFELDP TTLQKTDSFV PRNSYVRLRH LCTNTWIQST NVPIDIDEER PIRLMLGTCP
     TKEDKEAFAI VSVPVMEIRD LDFANDASAM LCTVVDKFNQ GFISQNDRRF AIKLLEDVVF
     FVADVINSGQ QVLDVVMSKV NRERQKLMRE QNILKQIFGI LKAPFKERSG GEGPLLRLEE
     LADQKNSPYQ YMFRLCYRVL RHSQEDYRKN QEYIAKQFGV MQSQIGYDIL AEDTITALLH
     NNRKLLEKHI TKTEVETFVS LVRKNREPRF LDYLSDLCVS NNVAIPVTQE LICKCVLEPK
     NQDILIKTER RIPKDSAPGG VQGEYLAMDD YGDEDEVWLV WMDKTSEKQE KSIRQLAQEA
     RQGNAHDENV LTYYRYQLKL FARMCLDRQY LAIDEISKQL DVELIFLCMM DETLPFDLRA
     SFCRLMLHAH VDRDPQELVT PVKFARLWTE IPTSISIKDY DSNMDDSRDN KKNRFSNTMV
     FMEEYLNNVL NDELPFHNEE KNKLTYEVVS LARHLIYFGF YSFFELLRLT RTLLGIIDCR
     PNPGYAGLLI NDDGTVGKNV KRSIHGVGQM MSTMVLNRKA SIFGGAGARG GSLGAGLVLE
     GQRCGKDSID KMDITVMDTK LKILEILQFI LNVRLDYRLS FLLSVFKKDF VDVYPMADAD
     ATTNLEEAGI QTEPSFIQHH WHIGEQAEAM FGVGKGNSIL EMDDEGGRMF LRVLIHLIMH
     NYAPLVSGAL QLLFRHFSQR QEVLHTFKQV QLLISSQDVE NYKLIKADLD RLRTLVEKSE
     LWVEKKNSGG GDGKKEKKDK KEKEEGASED APPKKEKADK GNENYHNVKE ILERLNKMCS
     TGVWKKQQRL LKNMGAHKVM LDLLQVSYDQ QNDTKMQEII RYTHLFLQKF CMGNQENQAL
     LHKNLNLFLN PGLLEAETVQ HIFSNNYQLC SEISESVLQH FIHCLATHGR HVQYLNFLHT
     IIKAEGKYVK KCQDMIMTEL TNAGEDVVVF YNDKTSFNAM LQLMAESREG VGENSPLSFR
     YHISLVELLA ACAEGKNVYT EIKCTSLLPL EDVVRVVTHE DCITEVKMAY VNFVNHCYVD
     TEVEMKEIYT SNHIWKLFED FTVDMARVCN KREKRLSDPI LEKYIINVVF DTINAFFSSP
     FSENSTSLQT HHTIVTQLLQ SSVRLLDCPW LQQQHRGQVE TCIKTLAMTA KSRSISLPLD
     LEAQISSMLS TSALNSLSRT NPNYRSTSRS SRPVASTNPW DYKNIIEKLQ DVINTLEERL
     KPLVNAELSV LVDVLHQPEL LFLEGTDARQ RCESGGFISK LIQHTKALMS AEEKLCIKVL
     RILQEMLIRT LDFDEKVSSN STASFQPKSS CSISALTRPS GSINVKLFHE QGIPLRKVLL
     QNYLFPNKKT NPKNDLAELG AAGKLCVSTL KVDAATNGES GGEQDRDWAA VAAVQCRLDR
     EGGTKLFTDL VMSTKNDKIF QESIQLAICL LEGGNTEIQN SFYKLMMGDN KSEKFFKVLH
     DRMKEAQTDI KATVSVNVGE MTYKANEKEL ETGKTRTRTR LRALVASVHH AAPPLAFYGD
     VRISRIRLHG NAVLPVQPVA EQKEVETEMG PAVTIMKPIL RFLQLLCENH NQDLQNFLRC
     QNNKTNYNLV CETLQFLDIM CGSTTGGLGL LGLYINESNV HLIIQTLETL TEYCQGPCQE
     NQTCIVTHES NGIDIITALI LNDISPLCRY RMEMVLQLKD NASKLLLALM ESRHDSENAE
     RIMINLRPRE LVEIIKKAYN QESEECEEDE VSPREVGHNI YILAQQLARH NKVLQNLLKS
     LKKSKEGEDP LEYYEQHTAQ IEIVREDRSM EQIVFPVHPI CEFLTEDSKF RVFNTTEQDE
     QGSKVTHFFE QTSFLHGEME WQKKLRSIPV LYWFSRRMSL WGTISFNLAV FINLIIAFFY
     PYDSGQVGAI DDSLLLMVFW ILTGLSVLGL FSQRYGLQPL TIALIIRSIY HLGLGNTLIL
     LGSLNLINKV VFVVSFVGNN GTFIMGYKAM VMDVEFLYHL AYVLTSTLGL FVHELFYSIL
     FDLIYREETL FNVIKSVTRN GRSILLTALL ALILVYLFSI VGFLFLKEDF IMEVDPLAQI
     AAAPPQSEAS RDFLKSCSAE EVSCVAESEV EEDGKMDHQY EASSERACDT LLMCIVTVLN
     HGLRNGGGVG DVLRKPSKNE PLFPARVVYD LLFYFIVIII VLNLIFGVII DTFADLRSEK
     QKKEEVLKTT CFICCLERDK FDNKTVSFEE HIKLEHNIWN YLYFIVLLRE KNKTDYTGPE
     SYVAHMIKNS NLDWFPRMQA MSLVVTDGDG EQNEMRMLQD KLGATMKVVH TLTTQLTELK
     EQMTEQRKRR QRMGFVDVQA GVSAALPP
//
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