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Database: UniProt
Entry: H2UH99_TAKRU
LinkDB: H2UH99_TAKRU
Original site: H2UH99_TAKRU 
ID   H2UH99_TAKRU            Unreviewed;      4884 AA.
AC   H2UH99;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   25-OCT-2017, entry version 37.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSTRUP00000036320};
GN   Name=RYR3 (1 of many) {ECO:0000313|Ensembl:ENSTRUP00000036320};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000036320, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000036320}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000036320}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000036320}.
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DR   Ensembl; ENSTRUT00000036451; ENSTRUP00000036320; ENSTRUG00000014204.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4425   4445       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4487   4510       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4634   4659       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4682   4704       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4763   4784       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       99    154       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      161    206       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      214    268       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      274    331       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      341    398       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      597    795       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1011   1210       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1256   1473       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3946   3972       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4884 AA;  552391 MW;  4F6E9363A6290C6A CRC64;
     IAACDSPGYD PVSLLKQDDE VVLQCVACIQ KENRKFCLAA EGLGNRLCYL EPTSEAKYVP
     PDLCICTFVL EQSLSVRALQ EMLANSGQNS EGAAQSGGHK TLLYGHAILL RHSFSSMYLA
     CLKTSRSQTD KLSFDVGLQE DSTGEACWWT IHPASKQRSE GEKVRIGDDL ILVSLSSERY
     LHLSISNGNI QVDASFMQTL WNVHPICSGS NVEEGYLLGG HVIRLFHGHD EVVAIPGSDQ
     SEEEQRIVNY ETGKAGAKAR SLWRLEPLRI SWSGSHIRWG QPFRLRHLTT GHYLALTDDR
     GLVLQDRERS DTDATAFCFR ASKKQEKLEQ SPKRDIEGMG VAEIKYGDSL CFIMHVATGL
     WLSYQAPDVK SARLGPLKRR ACLHTEGHMD DGLTLQRCQH EESRAARIIR NTTLLFNRFV
     SYDNRSCETL VFLPVEEVLQ TLNDLIAYFQ LPDVELEHEE RQIKLRSLKN RQNLFKQEGM
     LNLVSNCIDR LNVYNSAAHF GECAGQEAGA AWKDILNLLY ELLAALIRGN RNNCTQFSNN
     LDWLVSKLER LESSSGILEV LHCILIESPE ALNIIQRGHI KSIISLLYKH GRNHKILDVL
     CSLCVCNGVA VRTNQNLICD HLLPKRDLLL QSQLVNVVQS MRPNIFLGVS EGSAQYKKWY
     YELMIDQVDH FVTSEPTHLR VGWANTKGYA PYPGGGEGWG GNGVGDDLYS FGFDGLHLWS
     GRVPRAAASL NQHILTSEDV VSCCLDLGAP SISFRINGQP VQGMFENFNA DGLFFPVASF
     SAGVKVRFLL GGRHGDFKFL PPSGYAPCYE ALLPKEKMKV EPVKEYKRDV AGVRDLLGTA
     QLLSQASFIP TPVETSQIIM PPHLEKVRDK LAENIHELWG MNKIELGWTY GKIRDDNKRQ
     HPCLVDFSKL PETEKNYNLQ MSTETLKTLL ALGCRVVQVN PNAENSLKKI KLTKNYMMSN
     GYKPSPLDLS DIKLTPGQEL LVDKLAENAH NVWAKDRIKQ GWTYGIQQDL KSKRNPRLVP
     YVLLDERTKK SNRDSLREAI RTLIGYGYNI EPSDQEGESG QTVERISVDK VRFFRVERTY
     AVKTGKWYFE FEAVTGGDMR VGWARPACKP DVELGTDAHA FVFDGYSPKG HCLHTGGRLF
     GRCWHAGDVV GCMINMQDKS MIFTLNGEIL ITTKGSELCF TDFDTEDGFI PVCSLGLAQV
     GRMNLGKDAS TFKYYTMCGL QEGFEPFAVN MNREVTMWFS KRLPTFVNVP KDHNHIAVTR
     IDGTIDSPPC LKVSHKTFGS QNSNADMVLC RLSMPIEFHS VFKSSPIADV NGIHEEDVLK
     VKHRYSSSHF THYYHSVRVF AGQDPAGVWV GWVTPDYHYY SNNFNLGKNR TVTVTLGDER
     GRVHERDSVK RSNCYMVWGG DATSAAHASS RSNVDLEIGC LIDLATGLVT FTINGKEIST
     SYQVEPNTKL FPAVFVRPTS ANLFQFELGK IKNAMPLSSA TFKSEHKNPV PQCPPRLDVQ
     TISAVLWSRM PNNFLKVDTA RVSERHGWVV QCVEPLQMLA VHIPEENRCV DIMELSEQED
     LRKFHYHTLK LYCALCALGN TRVAHALCSH LDQSQLLYTI DNQYLSGMLR EGCYNVLISI
     HLETAKEARL MMKDEFIIPV TPETRSIRLF FDATKKHRPP GVGLSTSLKP RFNFAPPCFI
     STKQEQHLYS PQVPLDTLKE KAISMLTEAV QGGGHHIRDP VGGCVEYQFV PILKLISTLL
     TMGVLASEDV HQILLLIDPN VFRETREEGN SGATDKEGLA GAVDKAVEAG EEEAAKEAKQ
     PLKGLLEKRL PEPVKRQMCE LLHYFCDCEL KHRIEAIVSF SDNFVSKLQF NQKYRYNELM
     LALNMSAAVT AKKTKEFRSP PQEQINMLLT FSTGDDCPCP SDIQEELYDF HNQLQLHCGI
     PMEEDQDEHY TSIRGRLLML VNKIKGQAHK SEEPSEKEQA APSNLKELIS QTMVSWAQEC
     HIQDPQLVRK MFSLLRRQYD SIGELLRAMR KTYTISASSV QDTINLLASL GQIRSLLSVR
     MGKEEEKLMI DGLGDIMNNK VFYQHPNLMR ILGMHETVME VMVNVLGGDK SQEIAFPKMV
     ASCCRFLCYF CRISRQNQKA MFDHLSYLLE NSSVGLASPS MRGSTPLDVA ASSVMDNNGL
     ALALEEPDLE KVVTYLAGCG LQSCPMLLAK GYPDIGWNPI EGERYLSFLR FAVFVNGESV
     EENSSVVVKL LIRRPECFGP ALRGEGGNGL LAAMKEAIKI SETPALDLPG SVHGVCSDVS
     ADGDDEEEVV HMGNAIMSFY SALIDLLGRC APEMHLINKG KGEALRIRAI LRSLVPTEDL
     VGIISIPLKM PIINKDGSVT EPDMSASFCP DHKAPMVLFL DRVYGIEDQS FLLHLLEVGF
     LPDLRAATSL DTEGLCTTET ALAMNRYIGS ALLPLLTRCA PLFAGTEHYA SLIDSTLHTI
     YRLSKGRSLT KAQRDAIEEC LLAVCKHLRP SMLQQLLRRL VFDVPLLSEY CKMPLRLLTN
     HYEQNWKYYC LPSGWGSYGT ASEDELLLTK KLFWGIFDSL SQRKYDPELF KMAMPCLSAI
     AGALPPDYVD ASISTAVEKP VSVDAQGNFD PKPINTANVS LPEKLEHFAN KYGEHLHEKW
     SAEKVLLGWK YGDSVDEKAK IHPQLRTYKS LTEKEKEIYR WPIRETLKSM LAMGWSIDRT
     KDGESMSQQR ESEKMRKISQ VSQANGFNPS PTDTSNVVLS RELQGMVEVV AENYHNIWAK
     KKKSDLGSRV KGGGPHPLLV PYDTLTAREK ARDREKAQDL FRFLQINGYS ITRGLKDLEQ
     DSSSMEKRFA YKFLKKLLKY VDQAQEFIAH LALAVEAMAA SGKTDRSPHE QEIKFFAKVL
     LPLIDQYFKN HCLYFLSSPN KNLSSSGYAS NKEKEMVTSL FCKLAALVRH RISLFGSDST
     TIVSCLHILA HTLDTRTVMK SGSELVRLGL RTFFENAAED LEKTFENLKL GKFTHSRSQM
     KGVSQNINYT TVALLPILTA LFEHITQHHF GVDLLLEDVQ VSCYRILTSL YALGTGKNIY
     VERQLPALGQ CLATLAGAMP VAFLEPLLNT YNPCSVFNTK SARERAILGI PGSVEEMCPG
     MPRLDGLMKD INDMAESGAR YTEMPHVIEV VLPMLCNYLS YWWEKGPENP LSSGGSVCCT
     TVTSEHLSVI LGNILKILNN NLGIDEASWM KRIAVYVQPI ISKARADLLR SHFLPTLEKL
     KKKTVKVVSE EELLKADGRG DTQEAELLIL DEFAVLCRDL YAFYPMLIRY VDNNRSRWLK
     EPDADSNELF RMVAEIFILW CKSHNFKREE QNFVVQNEIN NLSFLTGDNK TKMSKSFKEK
     SGGQDQERRH KKRRGEFYSI QTSLIVAALK KMLPIGLNMC TPGDQELISL AKTRYLLKDT
     DEEVKDHIQQ NLHLREKSED PAVRWQLNLY RDRALRFEGP PDPEKVLDRI QRISAAVFNL
     EQVEQPLRSK KCVWQKLLSK QRKRAVVACF RMAPLYNLPR HRSINLFLQA YQRIWIETEE
     YSFEEKLVQD LAKTQPKMEE EEEEEVKKQP DPLHQLILHF SHNALTECSS LEEDPLYIAY
     ADMMAKSCAE GEEEEEGKEK TFEEKEMEKQ KMLYQQARLH DRGAAEMVLQ MISASKGRLG
     AMVTVTLKLG ISILNGGNIL VQQKMLDYLK EKRDVGFFKS LSGLMMSCSV LDLNAFERQN
     KAEGLGMVTE EGSINVSEQG SKVLQDDEFT KDLFRFLQLL CEGHNNDFQN FLRTQTGNTT
     TVNIIISTVD YLLRLQESIS DFYWYYSGKD VIDEAGQRNF SRALAVAKQV FNSLTEYIQG
     PCVGNQQSLA HSRLWDAVVG FLHVFANMQM KLSQDSSQIE LLKELLDLQQ DMVVMMLSLL
     EGNVVNGTIG KQMVDTLVES SSNVEMILKF FDMFLKLKDL TTSDSFKEYD PENKGVISKK
     DFQKSMENQK QYSQSEIEFL LSCAEADEND MFNYKQFVDR FHEPAKDIGF NVAVLLTNLS
     EHMPHDARLS TFLDLAESVL SYFEPYLGRI EIMGGAKRIE RVYFEISESS RTQWEKPQVK
     ESKRQFIFDV VNERGESEKM ELFVNFCEDT IFEMQLASQI SEPDPVERSR GRRGRQPERA
     GKPGRGRGGE RAAGVVLAFT VACISMRKSL CHFRQLLTLR SIRRQYRTFR KMTVREMVQG
     FFSFFWIIIT GFLHFFYSLV WGFFHILWTT MFGGGFVEGA KNMKVTDILG NMPDPTQFGI
     HGDVLELEKI EANEASALAE IGQMSQGDAA EADLMAELLN IHPRNQGKHG SEPGLGDVSE
     MVVGDAPSIA SAVKQKKAEM AAKKTASNGE HKSDSEKADL EDGEKNDHAK TKDNAPQGSS
     VGEKKAPKKR PGQKKEPPEA FMASFLASVE IYQTKILNYL ARNFYNLRFL ALFVAFAINF
     ILLFYKVTGD YSDDEDPWNG RRRSGEEEEE GALEYFILQE STGYMAPALR CLAILHTIIS
     FLCVVGYYYL KVPLVVFKRE KEIARKLEFA GLYITEQPSD DDIKGQWDRL VINTPSFPNN
     YWDKFVKRKV IKKYGDLYGA ERIAELLGLD KSALDFNPTE ETVTKEASLV SWLSSIDTKY
     HVWKMGVVFT DNSFLYLVWY TTMSILGHYN NFFFAAHLLD IAMGFKTLRT ILSSVTHNGK
     QLVLTVGLLA VVVYLYTVVA FNFFRKFYNK SEDEDEPDMK CDDMMTCYLF HMYVGVRAGG
     GIGDEIEDPA GDPYELYRIL FDITFFFFVI VILLAIIQVA GLIIDAFGEL RDQQEQVKED
     METKCFICGI GNDYFDTTPH GFETHTLQEH NLANYLFFLM YLINKDETEH TGQESYVWKM
     YQERCWDFFP AGDCFRKQYE DQLG
//
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