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Database: UniProt
Entry: H2UHA0_TAKRU
LinkDB: H2UHA0_TAKRU
Original site: H2UHA0_TAKRU 
ID   H2UHA0_TAKRU            Unreviewed;      4872 AA.
AC   H2UHA0;
DT   21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2012, sequence version 1.
DT   22-NOV-2017, entry version 38.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSTRUP00000036321};
GN   Name=RYR3 (1 of many) {ECO:0000313|Ensembl:ENSTRUP00000036321};
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Takifugu.
OX   NCBI_TaxID=31033 {ECO:0000313|Ensembl:ENSTRUP00000036321, ECO:0000313|Proteomes:UP000005226};
RN   [1] {ECO:0000313|Ensembl:ENSTRUP00000036321}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551351;
RA   Kai W., Kikuchi K., Tohari S., Chew A.K., Tay A., Fujiwara A.,
RA   Hosoya S., Suetake H., Naruse K., Brenner S., Suzuki Y., Venkatesh B.;
RT   "Integration of the genetic map and genome assembly of fugu
RT   facilitates insights into distinct features of genome evolution in
RT   teleosts and mammals.";
RL   Genome Biol. Evol. 3:424-442(2011).
RN   [2] {ECO:0000313|Ensembl:ENSTRUP00000036321}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSTRUP00000036321}.
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DR   Ensembl; ENSTRUT00000036452; ENSTRUP00000036321; ENSTRUG00000014204.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005226};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005226};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4413   4433       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4475   4498       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4622   4647       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4670   4692       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4751   4772       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       99    154       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      161    206       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      214    268       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      274    331       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      341    398       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      597    795       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1011   1208       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1254   1471       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3934   3960       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4872 AA;  550881 MW;  FEF71B806A990D55 CRC64;
     IAACDSPGYD PVSLLKQDDE VVLQCVACIQ KENRKFCLAA EGLGNRLCYL EPTSEAKYVP
     PDLCICTFVL EQSLSVRALQ EMLANSGQNS EGAAQSGGHK TLLYGHAILL RHSFSSMYLA
     CLKTSRSQTD KLSFDVGLQE DSTGEACWWT IHPASKQRSE GEKVRIGDDL ILVSLSSERY
     LHLSISNGNI QVDASFMQTL WNVHPICSGS NVEEGYLLGG HVIRLFHGHD EVVAIPGSDQ
     SEEEQRIVNY ETGKAGAKAR SLWRLEPLRI SWSGSHIRWG QPFRLRHLTT GHYLALTDDR
     GLVLQDRERS DTDATAFCFR ASKKQEKLEQ SPKRDIEGMG VAEIKYGDSL CFIMHVATGL
     WLSYQAPDVK SARLGPLKRR ACLHTEGHMD DGLTLQRCQH EESRAARIIR NTTLLFNRFV
     SYDNRSCETL VFLPVEEVLQ TLNDLIAYFQ LPDVELEHEE RQIKLRSLKN RQNLFKQEGM
     LNLVSNCIDR LNVYNSAAHF GECAGQEAGA AWKDILNLLY ELLAALIRGN RNNCTQFSNN
     LDWLVSKLER LESSSGILEV LHCILIESPE ALNIIQRGHI KSIISLLYKH GRNHKILDVL
     CSLCVCNGVA VRTNQNLICD HLLPKRDLLL QSQLVNVVQS MRPNIFLGVS EGSAQYKKWY
     YELMIDQVDH FVTSEPTHLR VGWANTKGYA PYPGGGEGWG GNGVGDDLYS FGFDGLHLWS
     GRVPRAAASL NQHILTSEDV VSCCLDLGAP SISFRINGQP VQGMFENFNA DGLFFPVASF
     SAGVKVRFLL GGRHGDFKFL PPSGYAPCYE ALLPKEKMKV EPVKEYKRDV AGVRDLLGTA
     QLLSQASFIP TPVETSQIIM PPHLEKVRDK LAENIHELWG MNKIELGWTY GKIRDDNKRQ
     HPCLVDFSKL PETEKNYNLQ MSTETLKTLL ALGCRVVQVN PNAENSLKKI KLTKNYMMSN
     GYKPSPLDLS DIKLTPGQEL LVDKLAENAH NVWAKDRIKQ GWTYGIQQDL KSKRNPRLVP
     YVLLDERTKK SNRDSLREAI RTLIGYGYNI EPSDQEGESG QTVERISVDK VRFFRVERTY
     AVKTGKWYFE FEAVTGGDMR VGWARPACKP DVELGTDAHA FVFDGYRGHC LHTGGRLFGR
     CWHAGDVVGC MINMQDKSMI FTLNGEILIT TKGSELCFTD FDTEDGFIPV CSLGLAQVGR
     MNLGKDASTF KYYTMCGLQE GFEPFAVNMN REVTMWFSKR LPTFVNVPKD HNHIAVTRID
     GTIDSPPCLK VSHKTFGSQN SNADMVLCRL SMPIEFHSVF KSSPIADVNG IHEEDVLKVK
     HRYSSSHFTH YYHSVRVFAG QDPAGVWVGW VTPDYHYYSN NFNLGKNRTV TVTLGDERGR
     VHERDSVKRS NCYMVWGGDA TSAAHASSRS NVDLEIGCLI DLATGLVTFT INGKEISTSY
     QVEPNTKLFP AVFVRPTSAN LFQFELGKIK NAMPLSSATF KSEHKNPVPQ CPPRLDVQTI
     SAVLWSRMPN NFLKVDTARV SERHGWVVQC VEPLQMLAVH IPEENRCVDI MELSEQEDLR
     KFHYHTLKLY CALCALGNTR VAHALCSHLD QSQLLYTIDN QYLSGMLREG CYNVLISIHL
     ETAKEARLMM KDEFIIPVTP ETRSIRLFFD ATKKHRPPGV GLSTSLKPRF NFAPPCFIST
     KQEQHLYSPQ VPLDTLKEKA ISMLTEAVQG GGHHIRDPVG GCVEYQFVPI LKLISTLLTM
     GVLASEDVHQ ILLLIDPNVF RETREEGNSG ATDKEGLAGA VDKAVEAGEE EAAKEAKQPL
     KGLLEKRLPE PVKRQMCELL HYFCDCELKH RIEAIVSFSD NFVSKLQFNQ KYRYNELMLA
     LNMSAAVTAK KTKEFRSPPQ EQINMLLTFS TGDDCPCPSD IQEELYDFHN QLQLHCGIPM
     EEDQDEHYTS IRGRLLMLVN KIKGQAHKSE EPSEKEQAAP SNLKELISQT MVSWAQECHI
     QDPQLVRKMF SLLRRQYDSI GELLRAMRKT YTISASSVQD TINLLASLGQ IRSLLSVRMG
     KEEEKLMIDG LGDIMNNKVF YQHPNLMRIL GMHETVMEVM VNVLGGDKSQ EIAFPKMVAS
     CCRFLCYFCR ISRQNQKAMF DHLSYLLENS SVGLASPSMR GSTPLDVAAS SVMDNNGLAL
     ALEEPDLEKV VTYLAGCGLQ SCPMLLAKGY PDIGWNPIEG ERYLSFLRFA VFVNGESVEE
     NSSVVVKLLI RRPECFGPAL RGEGGNGLLA AMKEAIKISE TPALDLPGSV HGVCSDVSAD
     GDDEEEVVHM GNAIMSFYSA LIDLLGRCAP EMHLINKGKG EALRIRAILR SLVPTEDLVG
     IISIPLKMPI INKDGSVTEP DMSASFCPDH KAPMVLFLDR VYGIEDQSFL LHLLEVGFLP
     DLRAATSLDT EGLCTTETAL AMNRYIGSAL LPLLTRCAPL FAGTEHYASL IDSTLHTIYR
     LSKGRSLTKA QRDAIEECLL AVCKHLRPSM LQQLLRRLVF DVPLLSEYCK MPLRLLTNHY
     EQNWKYYCLP SGWGSYGTAS EDELLLTKKL FWGIFDSLSQ RKYDPELFKM AMPCLSAIAG
     ALPPDYVDAS ISTAVEKPVS VDAQGNFDPK PINTANVSLP EKLEHFANKY GEHLHEKWSA
     EKVLLGWKYG DSVDEKAKIH PQLRTYKSLT EKEKEIYRWP IRETLKSMLA MGWSIDRTKD
     GESMSQQRES EKMRKISQVS QANGFNPSPT DTSNVVLSRE LQGMVEVVAE NYHNIWAKKK
     KSDLGSRVKG GGPHPLLVPY DTLTAREKAR DREKAQDLFR FLQINGYSIT RGLKDLEQDS
     SSMEKRFAYK FLKKLLKYVD QAQEFIAHLA LAVEAMAASG KTDRSPHEQE IKFFAKVLLP
     LIDQYFKNHC LYFLSSPNKN LSSSGYASNK EKEMVTSLFC KLAALVRHRI SLFGSDSTTI
     VSCLHILAHT LDTRTVMKSG SELVRLGLRT FFENAAEDLE KTFENLKLGK FTHSRSQMKG
     VSQNINYTTV ALLPILTALF EHITQHHFGV DLLLEDVQVS CYRILTSLYA LGTGKNIYVE
     RQLPALGQCL ATLAGAMPVA FLEPLLNTYN PCSVFNTKSA RERAILGIPG SVEEMCPGMP
     RLDGLMKDIN DMAESGARYT EMPHVIEVVL PMLCNYLSYW WEKGPENPLS SGGSVCCTTV
     TSEHLSVILG NILKILNNNL GIDEASWMKR IAVYVQPIIS KARADLLRSH FLPTLEKLKK
     KTVKVVSEEE LLKADGRGDT QEAELLILDE FAVLCRDLYA FYPMLIRYVD NNRSRWLKEP
     DADSNELFRM VAEIFILWCK SHNFKREEQN FVVQNEINNL SFLTGDNKTK MSKSGGQDQE
     RRHKKRRGEF YSIQTSLIVA ALKKMLPIGL NMCTPGDQEL ISLAKTRYLL KDTDEEVKDH
     IQQNLHLREK SEDPAVRWQL NLYRDRALRF EGPPDPEKVL DRIQRISAAV FNLEQVEQPL
     RSKKCVWQKL LSKQRKRAVV ACFRMAPLYN LPRHTNNNYF LNAYQHIWLE LNHENSDSGS
     LLSMLTKTQP KMEEEEEEEV KKQPDPLHQL ILHFSHNALT ECSSLEEDPL YIAYADMMAK
     SCAEGEEEEE GKEKTFEEKE MEKQKMLYQQ ARLHDRGAAE MVLQMISASK GRLGAMVTVT
     LKLGISILNG GNILVQQKML DYLKEKRDVG FFKSLSGLMM SCSVLDLNAF ERQNKAEGLG
     MVTEEGSSSK VLQDDEFTKD LFRFLQLLCE GHNNDFQNFL RTQTGNTTTV NIIISTVDYL
     LRLQESISDF YWYYSGKDVI DEAGQRNFSR ALAVAKQVFN SLTEYIQGPC VGNQQSLAHS
     RLWDAVVGFL HVFANMQMKL SQDSSQIELL KELLDLQQDM VVMMLSLLEG NVVNGTIGKQ
     MVDTLVESSS NVEMILKFFD MFLKLKDLTT SDSFKEYDPE NKGVISKKDF QKSMENQKQY
     SQSEIEFLLS CAEADENDMF NYKQFVDRFH EPAKDIGFNV AVLLTNLSEH MPHDARLSTF
     LDLAESVLSY FEPYLGRIEI MGGAKRIERV YFEISESSRT QWEKPQVKES KRQFIFDVVN
     ERGESEKMEL FVNFCEDTIF EMQLASQISE PDPVERSRGR RGRQPERAGK PGRGRGGERA
     AGVVLAFTVA CISMRKSLCH FRQLLTLRSI RRQYRTFRKM TVREMVQGFF SFFWIIITGF
     LHFFYSLVWG FFHILWTTMF GGGFVEGAKN MKVTDILGNM PDPTQFGIHG DVLELEKIEA
     NEASALAEIG QMSQGDAAEA DLMAELLNIH PRNQGKHGSE PGLGDVSEMV VGDAPSIASA
     VKQKKAEMAA KKTASNGEHK SDSEKADLED GEKNDHAKTK DNAPQGSSVG EKKAPKKRPG
     QKKEPPEAFM ASFLASVEIY QTKILNYLAR NFYNLRFLAL FVAFAINFIL LFYKVTGDYS
     DDEDPWNGRR RSGEEEEEGA LEYFILQEST GYMAPALRCL AILHTIISFL CVVGYYYLKV
     PLVVFKREKE IARKLEFAGL YITEQPSDDD IKGQWDRLVI NTPSFPNNYW DKFVKRKVIK
     KYGDLYGAER IAELLGLDKS ALDFNPTEET VTKEASLVSW LSSIDTKYHV WKMGVVFTDN
     SFLYLVWYTT MSILGHYNNF FFAAHLLDIA MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV
     VYLYTVVAFN FFRKFYNKSE DEDEPDMKCD DMMTCYLFHM YVGVRAGGGI GDEIEDPAGD
     PYELYRILFD ITFFFFVIVI LLAIIQVAGL IIDAFGELRD QQEQVKEDME TKCFICGIGN
     DYFDTTPHGF ETHTLQEHNL ANYLFFLMYL INKDETEHTG QESYVWKMYQ ERCWDFFPAG
     DCFRKQYEDQ LG
//
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